Results 101 to 110 of about 49,359 (254)
Cell Propagation of Cholera Toxin CTA ADP-Ribosylating Factor by Exosome Mediated Transfer [PDF]
In this study, we report how the cholera toxin (CT) A subunit (CTA), the enzyme moiety responsible for signaling alteration in host cells, enters the exosomal pathway, secretes extracellularly, transmits itself to a cell population.
Boussadia, Zaira+11 more
core +1 more source
Abstract Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI‐MSI) is an emerging imaging tool that allows visualisation of hundreds of analytes unbiasedly in a single experiment. This paper highlights the adaptations of MALDI‐MSI in different context in 2024, such as clinical diagnostic, pharmacology, forensics applications ...
Yuen Tung Ngai+3 more
wiley +1 more source
An accessible sialyllactose moiety on viral membrane gangliosides is shown to be essential for HIV-1 uptake into mature dendritic cells, thereby promoting viral transfer and infection of bystander CD4+ T lymphocytes.
N. Izquierdo-Useros+10 more
semanticscholar +1 more source
Quantification of gangliosides by microbore high performance liquid chromatography.
A highly sensitive analytical method was developed that allows the separation of ganglioside mixtures and quantification of individual non-derivatized gangliosides in the concentration range between 2 pmol and 1 nmol.
R Wagener, B Kobbe, W Stoffel
doaj
Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts [PDF]
Human islet amyloid polypeptide (hIAPP) is the primary component of the amyloid deposits found in the pancreatic islets of patients with type 2 diabetes mellitus. However, it is unknown how amyloid fibrils are formed in vivo.
Matsuzaki, Katsumi, Wakabayashi, Masaki
core +1 more source
Lipid components of gangliosides
The fatty acids and the long-chain bases of gangliosides from several sources were analyzed by means of gas-liquid chromatography. Stearic acid was found to be the major fatty acid component while palmitic and arachidic acids were found in small amounts, confirming previous observations. Hydroxy acids were not found in any significant amounts.
K. Sambasivarao, R.H. McCluer
openaire +4 more sources
“Ears of the Lynx” Sign on Brain MRI in Siblings With Spastic Paraplegia: A Case Report
ABSTRACT Background Hereditary spastic paraplegia (HSP) is a rare, clinically and genetically heterogenous condition that selectively affects the terminal segment of the descending corticospinal tract of the lumbar spine area, causing lower extremity spastic weakness with or without associated complex neurological symptoms.
Qingqing Wang, Manikum Moodley
wiley +1 more source
A simple and effective procedure has been developed for eliminating silica gel from gangliosides after preparative thin-layer chromatography. Gangliosides were extracted from the scraped silica gel with chloroform-methanol-water 10:10:3 (by volume) and ...
H Kubo, M Hoshi
doaj
Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins. [PDF]
Clostridium perfringens uses its large arsenal of protein toxins to produce histotoxic, neurologic and intestinal infections in humans and animals. The major toxins involved in diseases are alpha (CPA), beta (CPB), epsilon (ETX), iota (ITX), enterotoxin (
McClane, Bruce A+2 more
core +3 more sources
Gangliosides in Membrane Organization
Since the structure of GM1 was elucidated 55years ago, researchers have been attracted by the sialylated glycans of gangliosides. Gangliosides head groups, protruding toward the extracellular space, significantly contribute to the cell glycocalyx; and in certain cells, such as neurons, are major determinants of the features of the cell surface ...
Sonnino, Sandro+5 more
openaire +4 more sources