Results 71 to 80 of about 25,517 (218)

Dietary gangliosides rescue GM3 synthase deficiency outcomes in mice accompanied by neurogenesis in the hippocampus

Frontiers in Neuroscience
Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides. GM3 synthase deficiency (GM3SD) causes an absence of GM3 and all downstream biosynthetic derivatives, including all the a-, b-, c-series gangliosides, commonly found ...
Jin-ichi Inokuchi, Jin-ichi Inokuchi, Shinji Go, Akemi Suzuki, Osamu Nakagawasai, Takayo Odaira-Satoh, Lucas Veillon, Takahiro Nitta, Paul McJarrow, Hirotaka Kanoh, Kei-ichiro Inamori, Koichi Tan-No, Michael Collett   +12 more
doaj   +1 more source

Anti-ganglioside M1 autoantibodies in Egyptian children with autism: a cross-sectional comparative study [PDF]

, 2022
Reham Mohammad Raafat Hamed, Magda Ayoub, Mai Abdel Samie, Nancy Nabil Hamam   +3 more
openalex   +1 more source

The Phospholipid Bis(monoacylglycero)Phosphate Confers Antitumour Immunogenicity to Exosomes Secreted by Dendrogenin A, Which Activates Its Biosynthesis in Tumour Cells

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Dendrogenin A stimulates, via LXRβ, the expression and activity of enzymes responsible for the biosynthesis of the phospholipid BMP. BMP is a key determinant of the antitumour immunogenicity of exosomes secreted by DDA‐treated melanoma and triple‐negative breast cancer cells and enhances mouse survival and anti‐PD‐1 therapy in melanoma.
Julio Buñay, Michel Record, Philippe de Medina, Silia Ayadi, Laly Pucheu, Céline Colacios, Bruno Ségui, Marcus Höring, Gerhard Liebisch, Hélène Martin, Marc Poirot, Sandrine Silvente‐Poirot   +11 more
wiley   +1 more source

Gangliosides enhance M2-polarized macrophage elongation induced by IL-4 and IL-13 [PDF]

Kosin Medical Journal
Background Macrophage polarization plays a crucial role in the immune response, and gangliosides regulate macrophage function. In this study, we investigated the role of gangliosides in modulating macrophage morphology and function in response to M2 ...
Snehal Chandrakant Meshram, Hee-Jin Choi, Minkyoung Cho, Jaewon Shim, Ki-Tae Ha, Sung-Jin Bae   +5 more
doaj   +1 more source

Antibody‐Targeted Artificial T Cell and Natural Killer Cell Derived Vesicles for Cancer Immunotherapy

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
ABSTRACT T cell and NK92 cell‐derived extracellular vesicles or artificial cell‐derived vesicles (ACDVs) exhibit anti‐cancer effects through inherited cytotoxic proteins like perforin and granzyme or transmembrane receptors like FasL and TRAIL. The anti‐cancer potential of artificial T and NK vesicles has been improved by attaching targeting moieties ...
Brijesh Parlekar, David W. Livingstone, Ashley R. Sutherland, Andrés X. Medina, Wendy Bernhard, John DeCoteau, Tays Hernández, Clarence Ronald Geyer   +7 more
wiley   +1 more source

Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence [PDF]

, 2021
Dragana Fabris, Ivana Karmelić, Hasan Muharemović, Tomislav Sajko, Mia Jurilj, Slavica Potočki, Ruđer Novak, Željka Vukelić   +7 more
openalex   +1 more source

Development of a Novel Extracellular Vesicle‐Based Biomarker Approach for Pediatric High‐Grade Glioma

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Pediatric high‐grade gliomas (pHGGs) account for 20% of childhood brain tumours and are associated with poor survival. Currently, pHGG detection relies on MRI, a costly and time‐consuming procedure. Extracellular vesicles (EVs) carry molecular markers indicative of their cellular origin and can be isolated from various biofluids, offering an ...
Adriana Fernandez Garcia, Poorvi Iyer, Pablo Ashi, Ibukunoluwa Tella, Vennela Sangaraboina, Dhruv Bhagat, Chelva Janarthanam, Alejandra Bargues‐Carot, Anumantha G. Kanthasamy, Thomas Spoerer, Morgane E. Golan, Steven L. Stice, Kosuke Funato   +12 more
wiley   +1 more source

Interaction of G_M1 Ganglioside with Bovine Serum Albumin Formation and Isolation of Multiple Complexes [PDF]

, 1980
M. Tomasi, L. Giorgio Roda, Clara Maria Ausiello, G D'Agnolo, Bruno Venerando, Riccardo Ghidoni, Sandro Sonnino, Guido Tettamanti   +7 more
openalex   +1 more source

Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response [PDF]

, 2023
Lachlan P. Deimel, Xiaochao Xue, Aziz Khan, L. Moynié, Charles Buchanan, Guoxuan Sun, Ryan McBride, Heiko Schuster, Charles Gauthier, Regis Saliba, Karolis Leonavicus, Leanne Minall, Guillaume Bort, Rebecca A. Russell, Erdinç Sezgin, James C. Paulson, Daniel C. Anthony, Andrew J. Baldwin, James H. Naismith, Torben Schiffner, Benjamin G. Davis, Quentin J. Sattentau   +21 more
openalex   +1 more source

Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions

Aging Cell, Volume 25, Issue 2, February 2026.
Hematopoietic aging arises from intrinsic stem‐cell decline and bone‐marrow niche dysfunction, leading to myeloid skewing, immunosenescence, and clonal hematopoiesis. These changes drive systemic inflammation and multi‐organ disease, which in turn further disrupt the bone‐marrow niche and hematopoietic stem cell (HSC) function, creating a vicious cycle
Masashi Miyawaki, Seiji Hashimoto, Sumito Ogawa, Yoshitaka Kase   +3 more
wiley   +1 more source