Results 91 to 100 of about 10,080 (200)

Fig. 4 in Twelve undescribed derivatives of ganoderic acid isolated from Ganoderma luteomarginatum and their cytotoxicity against three human cancer cell lines

, 2021
Fig. 4. The pro-apoptotic effect of compound 1 on HGC-27 cells. The cells were treated with different concentrations of 1 for 48 h and visualized for apoptotic bodies under fluorescent microscopy after staining with Hoechst 33,258.Published as part of Li,
Guo, Li, Liu, Fei, Zhou, Qin-Mei, Liu, Juan, Huang, Yuan-Jin, Xiong, Liang, Peng, Cheng, Su, Hai-Guo, Li, Xiao-Cui   +8 more
core   +1 more source

Ganoderic acid A alleviate psoriasis by inhibiting GSDMD-mediated pyroptosis

Tissue and Cell
Psoriasis is a chronic inflammatory dermatological condition characterized by the infiltration of inflammatory cells into the dermal layer. This study aimed to elucidate the anti-inflammatory properties and underlying molecular mechanisms of Ganoderic acid A in the treatment of psoriasis.A psoriasis model was induced in mice using IMQ to evaluate the ...
Chenggen Xiao, Junchen Chen, Xingchen Zhou, Hong Liu   +3 more
openaire   +2 more sources

Single‐cell sequencing and mass spectrometry imaging reveal the multicellular compartmentalization map of plant triterpenes: A ginsenoside in Panax ginseng example

Plant Biotechnology Journal, Volume 23, Issue 10, Page 4461-4476, October 2025.
Summary Revealing the multicellular compartmentalization map is crucial for plant breeding and metabolism regulation. Despite the importance of triterpenes as active compounds, there has been no report on their biosynthetic multicellular mapping. In this study, ginsenosides are used as an example to reveal the multicellular compartmentalization map of ...
Rubing Wang, Luyao Zhang, Xia Li, Wensong Sun, Yike Wang, Luqi Huang, Juan Wang, Wenyuan Gao, Lanping Guo   +8 more
wiley   +1 more source

Ganoderic acid targeting multiple receptors in cancer: in silico and in vitro study

Tumor Biology, 2016
Receptor tyrosine kinases (RTKs) are transmembrane high-affinity surface receptors responsible for cell migration, adhesion, apoptosis, metabolism, and cell proliferation activities in various cancers. Minute aberration in the RTK signaling modulates the downstream signaling pathways that results in cancer.
Balraj Singh, Gill, , Navgeet, Sanjeev, Kumar   +2 more
openaire   +2 more sources

Untargeted LC-QTOF-MS Analysis of Metabolites Produced by Penicillium brevicompactum during the Bioconversion of Ganoderic Acid A

, 2023
The repurposing of expired drugs through bioconversion remains one of the most crucial research milestones, as this practice reduces drug contamination while producing compounds of significance.
Kudzanai Tapfuma, Vizelle Naidoo, Ndiwanga F. Rasifudi, Lukhanyo Mekuto, Vuyo Mavumengwana   +4 more
core   +1 more source

Enhanced production of individual ganoderic acids by integrating Vitreoscilla haemoglobin expression and calcium ion induction in liquid static cultures of Ganoderma lingzhi

Microbial Biotechnology, 2019
Summary Ganoderic acids produced by Ganoderma exhibit anticancer and antimetastatic activities. A novel approach by combining Vitreoscilla haemoglobin (VHb) expression and calcium ion induction was developed to enhance ganoderic acid (GA) production in ...
Jun‐Wei Xu, Tong‐Hui Yue, Xuya Yu, Peng Zhao, Tao Li, Na Li   +5 more
doaj   +1 more source

Ethanolic Extract of Ganoderma mexicanum Pat. Mycelium: A Source of Bioactive Compounds with Antiproliferative Activity and Potential PPAR-γ Natural Ligands

Pharmaceuticals
Background/Objective: Ganoderma spp. have long been studied for their bioactive pharmacological properties, and their biomass and extracts have been obtained from various sources.
Lucia T. Angulo-Sanchez, Max Vidal-Gutiérrez, Heriberto Torres-Moreno, Martín Esqueda, Aldo Gutiérrez, Georgina Vargas, Juan Luis Monribot-Villanueva, José A. Guerrero-Analco, César Muñoz-Bacasehua, Ramón Enrique Robles-Zepeda   +9 more
doaj   +1 more source

MOESM1 of Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum

, 2019
Additional file 1: Figure S1. (A) The expression vector pJW-EXP-FPS. (B) Identification and characterization of the FPF gene-overexpressing strain. Amplification pattern of genomic PCR obtained with primers for the fusion of the gpd promoter and FPS gene fragment from different strains.
Fei, Yu, Li, Na, Zhang, De-Huai, Xu, Jun-Wei   +3 more
openaire   +1 more source

Anticancer Activity of Ganoderic Acid DM: Current Status and Future Perspective

Journal of Clinical & Cellular Immunology, 2017
Ganoderma lucidum is a mushroom that has a long history of medicinal use in the Far East countries as this mushroom is revered for its supposed miracle cures and life improving properties. Recently, this mushroom has come under scientific scrutiny to examine the possibility of finding biologically active compounds that may have an impact on human ...
Bryant, John Matthew, Bouchard, Mollie, Haque, Azizul   +2 more
openaire   +2 more sources

Synthesis of ganoderic acid analogues to investigate their activity as anti-prostate cancer agents [PDF]

Cancers are one of the leading causes of premature human death globally. Prostate cancer is the second most common cancer in the world; chemoprevention can help decrease the proportion of fatal cases and prevent recurrence of the cancer.
Al-Obaidi, Mohammed
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