Results 181 to 190 of about 701,063 (234)

Ganoderic acid A against cyclophosphamide‐induced hepatic toxicity in mice

Journal of Biochemical and Molecular Toxicology, 2018
AbstractThis study clarified the protective effect of ganoderic acid A (GAA) on cyclophosphamide (CP)‐induced hepatotoxicity in mice. Hepatic injury mice were induced by a single intraperitoneal injection of CP (200 mg/kg). The results showed that the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and liver of ...
Xu Lixin, Yan Lijun, Huang Songping
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A new ganoderic acid from Ganoderma lucidum mycelia and its stability

Fitoterapia, 2013
A new ganoderic acid (GA), 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid (1), together with four known compounds GA-Mk (2), -Mc (3), -S (4) and -Mf (5), was isolated and characterized from Ganoderma lucidum mycelia. The structure of compound 1 was elucidated on the basis of interpretation of extensive spectroscopic data (HRMS, IR, UV ...
Ying-Bo, Li, Ru-Ming, Liu, Jian-Jiang, Zhong   +2 more
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Ganoderic acid Sz, a new lanostanoid from the mushroom Ganoderma lucidum

Natural Product Research, 2005
A new lanostanoid, ganoderic acid SZ (1), isolated from a lipophilic extract of the fruiting body of Ganoderma lucidum, is a geometric Z-isomer of the known ganoderic acid S (2). The structure of ganoderic SZ (1) was deduced mainly by 1D and 2D NMR studies. During the course of this study, 12 known lanostanoids have also been isolated and characterized.
Canjun, Li, Jianhua, Yin, Fujiang, Guo, Decheng, Zhang, Hao H, Sun   +4 more
openaire   +2 more sources

Ganoderic Acid A To Alleviate Neuroinflammation of Alzheimer's Disease in Mice by Regulating the Imbalance of the Th17/Tregs Axis.

Journal of Agricultural and Food Chemistry, 2021
Ganoderic acid A (GAA) is a kind of lanostane-type triterpenoid isolated from Ganoderma lucidum. Imbalance of the Th17/Tregs axis exists in the progress of neuroinflammation of Alzheimer's disease (AD).
Yan Zhang, Xinyan Wang, Xiaomei Yang, Xiudong Yang, Jianfei Xue, Yanjun Yang   +5 more
semanticscholar   +1 more source

A new epoxidic ganoderic acid and other phytoconstituents from Ganoderma lucidum

Phytochemistry Letters, 2011
Abstract A new epoxidic ganoderic acid, 8α,9α-epoxy-3,7,11,15,23-pentaoxo-5α-lanosta-26-oic acid (1), together with the known compounds 3β-hydroxy-7,11,15,23-tetraoxo-5α-lanosta-8-en-26-oic acid (2), ergosta-7,22-diene-3β-yl pentadecanoate (3), ergosta-7,22-diene-3β-ol (4), β-sitosterol (5), fatty acids (6–10), fatty acid ester (11) and octadecane ...
Soniamol Joseph, Kainoor K. Janardhanan, Varughese George, Sabulal Baby   +3 more
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Ganoderic acid A protects lens epithelial cells from UVB irradiation and delays lens opacity

Chinese Journal of Natural Medicines, 2020
A contributory role of oxidative stress and protection by antioxidant nutrients have been suspected in cataract formation. Ganoderic acid A (GAA), an effective lanostane triterpene, is widely reported as an antioxidant. The aim of this study is to investigate the potential effects of GAA on cataract formation.
Li-Hua, Kang, Guo-Wei, Zhang, Jun-Fang, Zhang, Bai, Qin, Huai-Jin, Guan   +4 more
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Ganoderic acid a decreased Aβ42-induced neurotoxicity in PC12 cells by reduced mitochondrial damage

Brain Research
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Accumulation of β-amyloid (Aβ) in the brain has been recognized as a key factor in the onset and progression of Alzheimer's disease (AD).The accumulation of Aβ in the brain catalyzes the production of reactive oxygen species (ROS), which in turn triggers oxidative damage to cellular ...
Xiaoyuan Ding, Fan Liu, Haohao Wang, Yan Wang, Guohui Li, Xingen Zhang, Cheng Song, Fucheng Zhu, Dong Liu   +8 more
semanticscholar   +3 more sources

Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF‐Κb pathway

Chemical Biology and Drug Design, 2023
Osteoarthritis (OA) is a prevalent degenerative pathology, however, there exists a lack of cost‐effective pharmacological interventions that efficaciously inhibit its progression.
Yuan Liu, Chuankun Zhou, Jianye Tan, Tianlong Wu, Chongzhi Pan, Jiahao Liu, Xigao Cheng   +6 more
semanticscholar   +1 more source

Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth

Clinical and Translational Oncology, 2019
N-myc downstream-regulated gene 2 (NDRG2) is down-regulated in grade-III meningioma [anaplastic meningioma (AM)] and associated with clinically aggressive behavior. Current therapies in the treatment of high-grade meningioma are lacking with limited success.
A. Das, M. Alshareef, F. Henderson, J. L. Martinez Santos, W. A. Vandergrift, S. M. Lindhorst, A. K. Varma, L. Infinger, S. J. Patel, D. Cachia   +9 more
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Improving Lung Injury in Sepsis‐Related Systemic Inflammatory Response Syndrome Through Regulation of the TLR4/NF‐κB Pathway and Macrophage Polarization by Ganoderic Acid A

Chemical Biology and Drug Design
This study aimed to investigate the effects and mechanisms of Ganoderic acid A (GAA) on lung injury associated with systemic inflammatory response syndrome (SIRS). Forty Sprague Dawley rats were divided into four groups: Control group, GAA group (GAA, 40 
Mingjie Zhu, Jianru Shang, Shang Che
semanticscholar   +1 more source