Results 191 to 200 of about 701,063 (234)
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A ganoderic acid derivative, a highly oxygenated lanostane-type triterpenoid from Ganoderma lucidum
Phytochemistry, 1985Abstract Ganoderic acid C, a new lanostane-type triterpenoid was isolated from the fruit body of Ganoderma lucidum. The structure of ganoderic acid C was elucidated by spectroscopic data and X-ray analysis of methyl ganoderate C acetate.
Masao Hirotani +2 more
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International Journal of Medicinal Mushrooms
Alzheimer's disease (AD) represents a significant challenge in neurodegenerative disorders, characterized by the accumulation of amyloid-beta (Aβ) plaques and tau protein tangles in the brain. Current treatments provide symptomatic relief but do not halt
Abuzer Ali +3 more
semanticscholar +1 more source
Alzheimer's disease (AD) represents a significant challenge in neurodegenerative disorders, characterized by the accumulation of amyloid-beta (Aβ) plaques and tau protein tangles in the brain. Current treatments provide symptomatic relief but do not halt
Abuzer Ali +3 more
semanticscholar +1 more source
Biochemical Pharmacology, 2021
Major depressive disorder (MDD) is a common, chronic, recurrent disease. The existing drugs are ineffective for approximately half of patients, so the development of antidepressant drugs with novel mechanisms is urgent. Cumulative evidence has shown neuro-inflammation plays a key role in the etiology of major depressive disorder.
Hongkun Bao +14 more
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Major depressive disorder (MDD) is a common, chronic, recurrent disease. The existing drugs are ineffective for approximately half of patients, so the development of antidepressant drugs with novel mechanisms is urgent. Cumulative evidence has shown neuro-inflammation plays a key role in the etiology of major depressive disorder.
Hongkun Bao +14 more
openaire +2 more sources
Journal of Agricultural and Food Chemistry
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex gastrointestinal condition influenced by genetic, microbial, and environmental factors, among which the gut microbiota plays a crucial role and has emerged ...
Rong-Wei Kou +7 more
semanticscholar +1 more source
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex gastrointestinal condition influenced by genetic, microbial, and environmental factors, among which the gut microbiota plays a crucial role and has emerged ...
Rong-Wei Kou +7 more
semanticscholar +1 more source
A quantum chemical and statistical study of ganoderic acids with cytotoxicity against tumor cell
European Journal of Medicinal Chemistry, 2005A set of molecular properties (variables) of 24 ganoderic acids with cytotoxicities against Meth-A tumor cells was calculated by the molecular orbital semi-empirical method AM1 and ChemPropStd. Pattern recognition techniques, principal component analysis (PCA) and hierarchical cluster analysis (HCA) were employed to reduce dimensionality and ...
Hai-long, Yang +2 more
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Journal of Biotechnology, 2021
Ganoderic acids (GAs) produced by Ganoderma are a type of lanostane-type triterpenoids with anticancer and antimetastatic activities; however, low production of GAs limits its wide application. In this study, a novel strategy by promoting sporulation of Ganoderma was developed to increase GA production. First, a high-spore producing Ganoderma strain G.
Bin Sun, Hao You, Jun-Wei Xu
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Ganoderic acids (GAs) produced by Ganoderma are a type of lanostane-type triterpenoids with anticancer and antimetastatic activities; however, low production of GAs limits its wide application. In this study, a novel strategy by promoting sporulation of Ganoderma was developed to increase GA production. First, a high-spore producing Ganoderma strain G.
Bin Sun, Hao You, Jun-Wei Xu
openaire +2 more sources
The Journal of pharmacy and pharmacology
OBJECTIVES Reportedly, ganoderic acid A (GA-A) increases the sensitivity of hepatocellular carcinoma cells to cisplatin (DDP) chemotherapy. Therefore, this study aims to fathom the influence of GA-A on lung cancer cells.
Enhui Gong +8 more
semanticscholar +1 more source
OBJECTIVES Reportedly, ganoderic acid A (GA-A) increases the sensitivity of hepatocellular carcinoma cells to cisplatin (DDP) chemotherapy. Therefore, this study aims to fathom the influence of GA-A on lung cancer cells.
Enhui Gong +8 more
semanticscholar +1 more source
Food & Function, 2020
Ganoderic acid A (GA) is one of the most abundant triterpenoids in Ganoderma lucidum, and has been proved to possess a wide range of beneficial health effects. The aim of the current study is to investigate the amelioration effects and mechanism of GA on
Wei-ling Guo +9 more
semanticscholar +1 more source
Ganoderic acid A (GA) is one of the most abundant triterpenoids in Ganoderma lucidum, and has been proved to possess a wide range of beneficial health effects. The aim of the current study is to investigate the amelioration effects and mechanism of GA on
Wei-ling Guo +9 more
semanticscholar +1 more source
Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer
Molecular Biology Reports, 2016Evaluating anti-oxidant potential of Ganoderic acid A in STAT 3 pathway in Prostate cancer. Molecular docking and ADMET activities of different isoforms of ganoderic acid on STAT 3 pathway were performed by Maestro 9.6 (Schrödinger Inc). The ganoderic acid A is best-docked among isoforms which analyses the expression level of antioxidant and STAT 3 ...
Balraj Singh, Gill +2 more
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Journal of Ethnopharmacology
Ganoderma lucidum, a renowned tonic traditional Chinese medicine, is widely recognized for the exceptional activity in soothing nerves and nourishing the brain. It has been extensively employed to alleviate various neurological disorders, notably Parkinson's disease (PD).To appraise the antiparkinsonian effect of GAA, the main bioactive constituent of ...
Qiang‐Ming Li +5 more
semanticscholar +3 more sources
Ganoderma lucidum, a renowned tonic traditional Chinese medicine, is widely recognized for the exceptional activity in soothing nerves and nourishing the brain. It has been extensively employed to alleviate various neurological disorders, notably Parkinson's disease (PD).To appraise the antiparkinsonian effect of GAA, the main bioactive constituent of ...
Qiang‐Ming Li +5 more
semanticscholar +3 more sources