Results 61 to 70 of about 6,418 (158)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum

Redox Biology, 2018
Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to induce the biosynthesis of GA in G. lucidum.
Rui Liu, Pengfei Cao, Ang Ren, Shengli Wang, Tao Yang, Ting Zhu, Liang Shi, Jing Zhu, Ai-Liang Jiang, Ming-Wen Zhao   +9 more
doaj   +1 more source

Ganoderic acid and its derivatives as cholesterol synthesis inhibitors.

Chemical and Pharmaceutical Bulletin, 1989
Oxygenated lanosterol derivatives, which were isolated from Ganoderma lucidum (Polyporaceae) or their derivatives obtained by chemical conversion, were tested for their effect on cholesterol biosynthesis from 24,25-dihydrolanosterol by rat hepatic subcellular 10,000 x g supernatant fraction.
KOMODA, Yasuo, SHIMIZU, Masato, SONODA, Yoshiko, SATO, Yoshihiro   +3 more
openaire   +3 more sources

Multi‐Omics Analysis Reveals the Potential Preventive Mechanism of Lactobacillus salivarius Li01 Against L‐Arginine‐Induced Acute Pancreatitis in Mice

Microbial Biotechnology, Volume 19, Issue 1, January 2026.
This study reveals that Lactobacillus salivarius Li01 alleviates acute pancreatitis by increasing gut Paramuribaculum. This modulation of the microbiota and its steroid hormone metabolites suppresses the pancreatic TNF signaling pathway, uncovering a protective ‘gut‐metabolism‐immunity’ axis.
Jiamin Duan, Jing Lou, Feiyu Wang, Huiyong Jiang, Longxian Lv, Hongwei Fu   +5 more
wiley   +1 more source

Systemic Effect of Ganoderma lucidum Filtrate on Septoria Leaf Spot and Pycnidia Formation by Septoria lycopersici

Journal of Phytopathology, Volume 174, Issue 1, January/February 2026.
ABSTRACT This study aimed to evaluate the potential of the mycelial growth filtrate (MGF) from Ganoderma lucidum in providing systemic protection to tomato plants against Septoria lycopersici‐induced leaf spot and inhibiting the production of reproductive structures by the phytopathogen. In greenhouse experiments, foliar application of MGF at 40% (v/v)
Mycheli P. Cruz, Ricardo B. Felipini, Sergio M. Mazaro, Robson M. Di Piero   +3 more
wiley   +1 more source

Interaction of ganoderic acid on HIV related target: molecular docking studies [PDF]

Bioinformation, 2011
Trouver le remède ultime contre le VIH reste une tâche difficile depuis des décennies. Divers composés actifs ont été testés contre divers composants du virus dans le but d'arrêter le développement du virus chez l'hôte infecté. L'idée de trouver un remède à partir de composés naturels pharmacologiquement actifs connus est intrigante et pratique.
Rahmad Akbar, Wai Keat Yam
openaire   +2 more sources

Possibility of modernization of Ganoderma lucidum strains substrate

International Journal of Horticultural Science, 2005
Ganoderma lucidum (Reishi mushroom), the object of our experiments, is also known to contain medicinal compounds. This fungus has been used for many centuries as medicine in China.
P. Maszlavér, D. Kovácsné, K. Ferenc, E. Fehérvári-Póczik   +3 more
doaj   +1 more source

Medicinal Plants and Lead Phytomolecules as Immunomodulators: An Updated Review

BioMed Research International, Volume 2026, Issue 1, 2026.
All therapeutic interventions aimed at modulating the immune response to pathogens, self‐antigens, carcinogens, or xenogeneic antigens are referred to as immunomodulation, which either prevents hyperactivation or restores the appropriate response of the immune system.
Gurdeep Singh, Vikas Sharma, Blessing Nnenna Udeh, Baisakhi Banerjee   +3 more
wiley   +1 more source

Ganoderic Acid A Alleviates High‐Fat Diet‐Induced Lipid Metabolism Disorders in Mice by Inhibiting Intestinal Farnesoid X Receptor

Food Frontiers, Volume 6, Issue 6, Page 3108-3121, November 2025.
Ganoderic acid A (GA) improved lipid metabolism disorders by inhibiting intestinal FXR. GA markedly suppressed the ileal intestinal FXR activity. Then, GA changed bile acid composition and upregulated hepatic Cyp7a1 mRNA through decreasing FXR target genes encoded protein levels.
Feng Lu, Shanshan Ju, Yi Ying, Jihan Liu, Chengfeng Yang, Min Li, Hong Zhou, Baoxue Yang   +7 more
wiley   +1 more source

Phytofabricated Silver Nanoparticles From Vaccinium arctostaphylos L.: Anticancer Activity Against Breast Cancer Cells via Apoptosis Induction and Growth Suppression

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
This study demonstrates that phytofabricated silver nanoparticles (VACAgNPs) from Vaccinium arctostaphylos L. exhibit significant anticancer activity against breast cancer cells, inducing apoptosis and suppressing growth in both hormone‐responsive (MCF‐7) and triple‐negative (4T1, MDA‐MB‐231) subtypes. The nanoparticles enhanced reactive oxygen species
Nazila Soleimani, Zahra Keshtmand, Nader Goodarzi, Mohsen Akbaribazm   +3 more
wiley   +1 more source