Results 71 to 80 of about 7,010 (202)

Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids

open access: yesCurrent Research in Food Science, 2023
Ganoderma lucidum triterpenoids (GP) have been reported to help prevent and improve hyperlipidemia. Modulation of the gut microbiota was proposed as underlying factor as well as a novel measure to prevent and treat hyperlipidemia.
Aijun Tong   +7 more
doaj   +1 more source

Metabolome response to temperature-induced virulence gene expression in two genotypes of pathogenic Vibrio parahaemolyticus [PDF]

open access: yes, 2016
Relative concentration of metabolites identified in Vibrio parahaemolyticus ATCC17802. (XLSX 113 kb)
Bo Feng   +4 more
core   +3 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang   +7 more
wiley   +1 more source

Ganoderic acid loaded nano-lipidic carriers improvise treatment of hepatocellular carcinoma [PDF]

open access: yesDrug Delivery, 2019
This work evaluates nano-lipid carrier of ganoderic acid (GA) and molecular docking on various cancer signaling pathways, an attempt to improve the hepatic condition associated with hepatic carcinoma (HCC) induced by diethyl-nitrosamine (DEN) in Wistar rats. Molecular docking mechanism of GA was performed through binding simulation analysis for various
Mahfoozur Rahman   +7 more
openaire   +3 more sources

SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum

open access: yesRedox Biology, 2018
Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to induce the biosynthesis of GA in G. lucidum.
Rui Liu   +9 more
doaj   +1 more source

Farnesoid X Receptor as a potential protein target for mushroom LMW compounds: virtual screening using molecular docking [PDF]

open access: yes, 2017
Farnesoid X receptor (FXR) is a nuclear receptor protein involved in controlling several metabolic pathways, with bile acids as his natural ligands. FXR functions as a sensor for bile acids, thus promoting their clearance by controlling expression of ...
Abreu, Rui M.V., Ferreira, Isabel C.F.R.
core  

Chemodiversity, pharmacological activity, and biosynthesis of specialized metabolites from medicinal model fungi Ganoderma lucidum

open access: yesChinese Medicine
Ganoderma lucidum is a precious fungus, particularly valued for its dual use as both medicine and food. Ganoderic acids (GAs), the distinctive triterpenoids found in the Ganoderma genus, exhibit a wide range of pharmacological activities.
Yupeng Du   +4 more
doaj   +1 more source

Possibility of modernization of Ganoderma lucidum strains substrate

open access: yesInternational Journal of Horticultural Science, 2005
Ganoderma lucidum (Reishi mushroom), the object of our experiments, is also known to contain medicinal compounds. This fungus has been used for many centuries as medicine in China.
P. Maszlavér   +3 more
doaj   +1 more source

Multi‐Omics Analysis Reveals the Potential Preventive Mechanism of Lactobacillus salivarius Li01 Against L‐Arginine‐Induced Acute Pancreatitis in Mice

open access: yesMicrobial Biotechnology, Volume 19, Issue 1, January 2026.
This study reveals that Lactobacillus salivarius Li01 alleviates acute pancreatitis by increasing gut Paramuribaculum. This modulation of the microbiota and its steroid hormone metabolites suppresses the pancreatic TNF signaling pathway, uncovering a protective ‘gut‐metabolism‐immunity’ axis.
Jiamin Duan   +5 more
wiley   +1 more source

Ganoderic acid and its derivatives as cholesterol synthesis inhibitors.

open access: yesChemical and Pharmaceutical Bulletin, 1989
Oxygenated lanosterol derivatives, which were isolated from Ganoderma lucidum (Polyporaceae) or their derivatives obtained by chemical conversion, were tested for their effect on cholesterol biosynthesis from 24,25-dihydrolanosterol by rat hepatic subcellular 10,000 x g supernatant fraction.
Y, Komoda   +3 more
openaire   +3 more sources

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