Results 71 to 80 of about 6,418 (158)

Neuroprotective prospectives of triterpenoids

Exploration of Neuroscience
Neurological disorders including neurodegenerative disorders continue to pose significant therapeutic challenges. Triterpenoids, a diverse group of natural compounds found abundantly in plants, possess promising neuroprotective properties.
Apoorva A. Bankar, Vaishali P. Nagulwar, Nandkishor R. Kotagale, Nazma N. Inamdar   +3 more
doaj   +1 more source

Sustainable Natural Product Glycosylation: A Critical Evaluation of Biocatalytic and Chemical Approaches

ChemSusChem, Volume 18, Issue 20, October 23, 2025.
Developing a process to produce glycosylated natural products involves many decisions, and given the current climate crisis, the environmental impact of the various processes must be a major consideration. This review provides an overview of the various processes and a framework for which metrics should be quantified to select processes that are both ...
Felipe Mejia‐Otalvaro, Brianna Marie Lax, Onur Kırtel, Ditte Hededam Welner   +3 more
wiley   +1 more source

Ganoderic acid A alleviate psoriasis by inhibiting GSDMD-mediated pyroptosis

Tissue and Cell
Psoriasis is a chronic inflammatory dermatological condition characterized by the infiltration of inflammatory cells into the dermal layer. This study aimed to elucidate the anti-inflammatory properties and underlying molecular mechanisms of Ganoderic acid A in the treatment of psoriasis.A psoriasis model was induced in mice using IMQ to evaluate the ...
Chenggen Xiao, Junchen Chen, Xingchen Zhou, Hong Liu   +3 more
openaire   +2 more sources

Enhanced Production and Profiling of Ganoderic Acids in Ganoderma lucidum Mycelia via Two-Stage Cultivation and GNPS-Guided Metabolomics

Journal of Fungi
Ganoderic acids (GAs) are bioactive lanostane-type triterpenoids produced by Ganoderma lucidum that accumulate predominantly in fruiting bodies, whose long cultivation period limits their practical production.
Chieh-Hsi Tsao, Hsin-Ya Tsai, Kai-Wen Cheng, Guan-Yuan Chen, Hao-Ting Chen, Cheng-Chih Hsu, Nan-Wei Su   +6 more
doaj   +1 more source

MOESM1 of Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum

, 2019
Additional file 1: Figure S1. (A) The expression vector pJW-EXP-FPS. (B) Identification and characterization of the FPF gene-overexpressing strain. Amplification pattern of genomic PCR obtained with primers for the fusion of the gpd promoter and FPS gene fragment from different strains.
Fei, Yu, Li, Na, Zhang, De-Huai, Xu, Jun-Wei   +3 more
openaire   +1 more source

Current Techniques for the Cultivation of Ganoderma lucidum for the Production of Biomass, Ganoderic Acid and Polysaccharides

Food Technology and Biotechnology, 2003
Ganoderma lucidum is a medicinal mushroom that has been used in the Orient for more than 2000 years. Due to the long time required for basidiocarp formation, attention has recently been given to the use of submerged fermentation for the production of ...
Ricardo Wagner, Guilherme Lanzi Sassaki, Maria Angela Lopes de Almeida Amazonas, Marin Berovič, David Alexander Mitchell   +4 more
doaj  

Synergistic effects of exogenous inducers on ganoderic acid accumulation in Ganoderma lucidum: optimization and transcriptomic analysis

Medicinal Plant Biology
Ganoderic acids (GAs) are bioactive compounds in Ganoderma lucidum that have various pharmacological properties. Their biosynthesis is influenced by environmental factors and elicitors, but the synergistic effects of multiple inducers on GA accumulation ...
Yanhong Guo, Shuhao Xu, Xue Guo, Jing Xu, Zhenyu Li, Ying Wang, Zhenhao Li, Zheyong Xue   +7 more
doaj   +1 more source

Ganoderic acid targeting multiple receptors in cancer: in silico and in vitro study

Tumor Biology, 2016
Receptor tyrosine kinases (RTKs) are transmembrane high-affinity surface receptors responsible for cell migration, adhesion, apoptosis, metabolism, and cell proliferation activities in various cancers. Minute aberration in the RTK signaling modulates the downstream signaling pathways that results in cancer.
Balraj Singh, Gill, , Navgeet, Sanjeev, Kumar   +2 more
openaire   +2 more sources

Can Ganoderma Triterpenoids Exert Immunogenic Cell Death in Human Cancer Cells? A Systematic Review and Protein Network Analysis

Pharmaceuticals
Background: Permanent cancer resolution requires a complete immunological response with generation of memory against malignant cells. Immunogenic cell death (ICD) achieves this by coupling cell death with the emission of damage-associated molecular ...
Jorge C. Ramírez-Gutiérrez, J. Fernando Ayala-Zavala, Heriberto Torres-Moreno, Max Vidal-Gutiérrez, Martín Esqueda   +4 more
doaj   +1 more source

Anticancer Activity of Ganoderic Acid DM: Current Status and Future Perspective

Journal of Clinical & Cellular Immunology, 2017
Ganoderma lucidum is a mushroom that has a long history of medicinal use in the Far East countries as this mushroom is revered for its supposed miracle cures and life improving properties. Recently, this mushroom has come under scientific scrutiny to examine the possibility of finding biologically active compounds that may have an impact on human ...
Bryant, John Matthew, Bouchard, Mollie, Haque, Azizul   +2 more
openaire   +2 more sources