Results 81 to 90 of about 6,819 (187)

Promotion of ganoderic acid production in Ganoderma sinense by the addtion of an ether extract from Eupolyphaga sinensis, a medicinal insect [PDF]

, 2013
To screen stimulators from Chinese medicinal insects for mycelial growth and ganoderic acid (GA) production by Ganoderma sinense, the fungus was inoculated into the media with and without supplementation of a medicinal insect extract.
Han, WJ, Liu, GQ, Wang, XL, Wu, TH, Zhang, HY, Zhang, YG   +5 more
core   +2 more sources

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, Volume 45, Issue 9, Page 1128-1161, September 2025.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Ganoderic acid and its derivatives as cholesterol synthesis inhibitors.

Chemical and Pharmaceutical Bulletin, 1989
Oxygenated lanosterol derivatives, which were isolated from Ganoderma lucidum (Polyporaceae) or their derivatives obtained by chemical conversion, were tested for their effect on cholesterol biosynthesis from 24,25-dihydrolanosterol by rat hepatic subcellular 10,000 x g supernatant fraction.
Y, Komoda, M, Shimizu, Y, Sonoda, Y, Sato   +3 more
openaire   +3 more sources

Department of Metabolic Engineering [PDF]

, 2002
薬物代謝工学部門は和漢薬の薬効，毒性発現に関与する代謝系の分子生物学的研究を発展させることを設置目的とし，①和漢薬の薬効発現に関与する腸内細菌遺伝子の解析，②薬物代謝機能調節遺伝子の解明とその応用，③腎毒性物質産生機構の分子生物学的解明とその制御に関する研究を課題として取りあげ，和漢薬の薬効発現機構，生体へのレスポンスなどの基礎的研究を通じて，和漢薬の科学的評価や臨床応用をはかることを目指している。主な研究題目を以下に示す。1.
中村 憲夫, 宮代 博継, 服部 征雄, 横澤 隆子   +3 more
core   +2 more sources

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

MedComm, Volume 6, Issue 9, September 2025.
Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen, Jiachen Liu, Yinhuai Wang, Zebin Deng, Fei Deng   +4 more
wiley   +1 more source

The Biological Activity of Ganoderma lucidum on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks

Molecules
Neurodegenerative diseases represent a cluster of conditions characterized by the progressive degeneration of the structure and function of the nervous system.
Wenhui Lian, Xu Yang, Qidong Duan, Jie Li, Yuting Zhao, Chunhui Yu, Tianzhu He, Tianxia Sun, Yu Zhao, Weinan Wang   +9 more
doaj   +1 more source

Sirt3 Rescues Porphyromonas gingivalis‐Impaired Cementogenesis via SOD2 Deacetylation

Cell Proliferation, Volume 58, Issue 9, September 2025.
Sirt3 deacetylated SOD2 via K68 to orchestrate P.g.‐impaired cementogenesis. Reestablishment of the Sirt3/SOD2 axis by honokiol reduced SOD2 acetylation and facilitated cementogenesis. ABSTRACT The keystone pathogen Porphyromonas gingivalis (P.g.) is responsible for cementum resorption in periodontitis; however, the mechanism involved in it remains ...
Xin Huang, Huiqing Gou, Jirong Xie, Yonglin Guo, Yifei Deng, Yan Xu, Zhengguo Cao   +6 more
wiley   +1 more source

Jianpi‐Huogu Prescription Repairs Nontraumatic Osteonecrosis of the Femoral Head by Inhibiting NAMPT/STK11/HMGCR/ACAT1 Axis‐Mediated Lipid Production

Journal of Cellular and Molecular Medicine, Volume 29, Issue 18, September 2025.
ABSTRACT Jianpi‐Huogu Prescription (JHP), integrating the classic Chinese herbal formulas Linggui‐Zhugan Decoction and Si‐Wu Decoction, has shown clinical efficacy in treating early nontraumatic osteonecrosis of the femoral head (NONFH). In this study, 299 chemical constituents of JHP were identified using ultra‐performance liquid chromatography ...
Tao Li, Zhaochen Ma, Shuangrong Gao, Chu Zhang, Yan Jia, Huang Feng, Na Lin, Weiheng Chen, Yanqiong Zhang   +8 more
wiley   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, Volume 12, Issue 31, August 21, 2025.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

Quality Difference Study of Six Varieties of Ganoderma lucidum with Different Origins [PDF]

, 2012
The quality difference of six varieties Ganoderma lucidum with different origins was investigated in this study by comparing the contents of ganoderic acid A and B, polysaccharide, and triterpenoids. The contents of ganoderic acid A and B in G.
Chen, Ping, Chen, Xi, Lu, Juan, Qin, Jia-Zhang, Zhang, Ying-Zhi, Zhao, Si-Jia   +5 more
core   +3 more sources