Results 181 to 190 of about 20,660 (301)

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila [PDF]

, 2019
Augusto V. Gonçalves, Shally R. Margolis, Gustavo F. S. Quirino, Danielle P. A. Mascarenhas, Isabella Rauch, Randilea Nichols Doyle, Eduard Ansaldo, Mary F. Fontana, Russell E. Vance, Dario S. Zamboni   +9 more
openalex   +1 more source

Image_2_Extracellular CIRP Induces Macrophage Extracellular Trap Formation Via Gasdermin D Activation.tif

, 2021
Yongchan Lee (8128929), Bridgette Reilly (11869661), Chuyi Tan (11869664), Ping Wang (42415), Monowar Aziz (339592)   +4 more
openalex   +2 more sources

Non‐HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 3, March 2026.
ABSTRACT Aim The genetic loci, ERBB2/IKZF3/GSDMB/ORMDL3 on chromosome 17q, and ERBB3/IKZF4 on chromosome 12q represent confirmed non‐HLA risk factors for the development of autoimmunity and progression to type 1 diabetes (T1D). It is unknown whether both regions can interact to influence the progression of T1D.
Ina M. Mertens, Bart Keymeulen, Frans K. Gorus, Mark Van De Casteele, the Belgian Diabetes Registry   +4 more
wiley   +1 more source

Cardamonin Commands the Colonic Metabolite Columbianetin Acetate to Compete Against LPS in Binding HMGB1 in the Kidney, Preventing Lipopolysaccharide‐Induced Renal Tubular Pyroptosis

Food Frontiers, Volume 7, Issue 2, March 2026.
Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou, Xuechun Sun, Jian Zhou, Huali Meng, Pengfei Fan, Yufeng Chu, Hao Wu   +6 more
wiley   +1 more source

Pore Formation Mechanism of Human Gasdermin D [PDF]

Biophysical Journal, 2020
Shiyu Xia, Jianbin Ruan, Juan Lorenzo Pablo, Zhibin Zhang, Longfei Wang, Tian-Min Fu, Anna Greka, Judy Lieberman, Hao Wu   +8 more
openaire   +1 more source

Cardiolipin Oxidized By Complex II Acts a Target of Gasdermin D to Drive Mitochondrial Apoptotic Pore Forming and Heart Dysfunction in Endotoxemia

, 2023
Yan Tang, Junru Wu, Xuejing Sun, Wenbo Li, He Tian, Siyu Yin, Lun Liu, Yuanyuan Chen, Yuanyuan Liu, Qian Tan, Youxiang Jiang, Wen Yang, Wei Huang, Chunyan Weng, Qing Wu, Yao Lu, Hong Yuan, Qingzhong Xiao, Qingbo Xu, Timothy R. Billiar, Jingjing Cai   +20 more
openalex   +1 more source

Dihydromyricetin Regulates PANoptosis to Protect Salmonella Typhimurium‐Infected Weaned Piglets

Food Frontiers, Volume 7, Issue 2, March 2026.
After DHM pretreatment, piglets were subjected to Salmonella infection. Serum and ileocecal samples from the piglets were collected for TUNEL assay, Western blotting analysis, and metabolomics analysis. The results collectively indicated that DHM could protect piglets from Salmonella infection.
Tingting Xiao, Xinyi Tian, YiKun Li, Jie Zhang, Hongcan Huang, Yu‐Xuan Lyu, Baichuan Deng   +6 more
wiley   +1 more source

Non‐Starch Purple Sweet Potato Polysaccharide Ameliorates Lipopolysaccharides‐Induced Acute Colitis by Regulating Gut Function and Inactivating the NOD‐Like Receptor Protein 3 Signaling Pathway

Food Frontiers, Volume 7, Issue 2, March 2026.
Purple sweet potato polysaccharide (PSP) ameliorates lipopolysaccharide‐induced ulcerative colitis in mice through multiple coordinated mechanisms. Oral PSP administration dose‐dependently: (1) Modulates gut microbiota composition and increases short‐chain fatty acid levels; (2) strengthens intestinal barrier function; (3) attenuates systemic ...
Peng Yu, Jitao Ling, Yixuan Chen, Panpan Xia, Yuting Wu, Jianqi Liang, Xuehong Zheng, Yunkun Liu, Zhou Xu, Yiming Gan, Ao Shi, Wenting Wang, Xiao Liu, Yaqi Rong, Yan Xiong, Jianping Liu, Xiaoping Yin, Jing Zhang, Deju Zhang   +18 more
wiley   +1 more source

Extracellular Vesicles‐Functionalized Biomaterials for Oral Disease Theragnostics

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
Combining EVs with biomaterials enables sustained, targeted delivery and overcomes traditional limitations. EVs show great promise in diagnosing and treating oral diseases, and could transform oral health management strategies. ABSTRACT Oral diseases impair oral function and are closely linked to various systemic conditions.
Zhe Zhao, Yiyu Zeng, Rui Liu, Xuemei Qiu
wiley   +1 more source

Pyroptosis-mediator Gasdermin D in serum: a potential biomarker in diabetic kidney disease. [PDF]

Front Endocrinol (Lausanne)
Ding N, Wei C, Liu Q, Liu X, Huo L, Yu F, Yang C.   +6 more
europepmc   +1 more source