Results 41 to 50 of about 488,720 (294)

A Standardized Pathology Report for Gastric Cancer: 2nd Edition [PDF]

open access: yes, 2023
The first edition of ‘A Standardized Pathology Report for Gastric Cancer’ was initiated by the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists and published 17 years ago. Since then, significant advances have been made in the
김현기   +28 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Representative chromatograms of NAAB-496 (A) degradation after gastric (B) and gastric plus duodenal digestion (C).

open access: yes, 2019
Representative chromatograms of NAAB-496 (A) degradation after gastric (B) and gastric plus duodenal digestion (C).
Carlo Bisignano (4587745)   +11 more
core   +1 more source

Rate of gastric digestion in the larvicidal fishes Aplocheilus lineatus (Cuv. & Val.) and Macropodus cupanus (Cuv. & Val.) [PDF]

open access: yes, 1981
In the larvicidal fishes Aplocheilus lineatus and Macropodus cupanus investigations on the rate of gastric digestion reveal that interspecific variations are apparent; however, within the species, digestion rate is not significantly altered by fish size ...
Nair, N. Balakrishnan   +3 more
core   +1 more source

The contribution of gastric digestion of starch to the Glycaemic Index of breads with different composition or structure

open access: yes, 2022
International audienceBreads of higher density exhibit lower glycaemic index (GI) both in vivo and in vitro, a phenomenon generally attributed to a slower intestinal starch digestion.
Souchon, Isabelle   +2 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Digestion of protein and toxic gluten peptides in wheat bread, pasta and cereal and the effect of a supplemental enzyme mix

open access: yesFrontiers in Nutrition, 2022
There has been an increasing interest in the relationship between wheat digestibility and potential toxicity to the host. However, there is a lack of understanding about temporal profile of digestion of wheat proteins from different food matrices under ...
Daniela Freitas   +2 more
doaj   +1 more source

Effects of recombinant human gastric lipase and pancreatin during in vitro pediatric gastro-intestinal digestion [PDF]

open access: yes, 2021
The aim of the study was to implement a gastric digestion step using recombinant human gastric lipase (rHGL) in an in vitro pediatric gastro-intestinal digestion model to achieve a physiologically relevant gastric contribution to total gastro-intestinal ...
Geng, Xiaolu   +12 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

In vitro simulated study of macronutrient digestion in complex food using digestive enzyme supplement

open access: yesHeliyon
Digestive enzymes secreted by the body are vital for digestion and nutrient absorption. Enzyme supplements are commonly used to support them in achieving optimal digestion.
Abhijit Rathi   +4 more
doaj   +1 more source

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