Results 31 to 40 of about 59,555 (264)

Acute effects of elevated NEFA on vascular function: a comparison of SFA and MUFA [PDF]

, 2010
There is emerging evidence to show that high levels of NEFA contribute to endothelial dysfunction and impaired insulin sensitivity. However, the impact of NEFA composition remains unclear.
Abby K. Thompson, Beysen, Christine M. Williams, Hogikyan, John Wright, Katie J. Newens, Kim G. Jackson, Wang, Xiao-Yun, Zampelas   +9 more
core   +1 more source

Efficacy and Safety of Tirzepatide in Type 2 Diabetes and Obesity Management

Journal of Obesity & Metabolic Syndrome, 2023
The combination of glucagon-like peptide-1 (GLP-1) with other gut hormones including the glucose-dependent insulinotropic polypeptide (GIP) has been explored to complement and enhance further the GLP-1 effects on glycemia and weight loss.
Rachel Sinha, Dimitris Papamargaritis, Jack A. Sargeant, Melanie J. Davies   +3 more
doaj   +1 more source

Factors Related to Blood Intact Incretin Levels in Patients with Type 2 Diabetes Mellitus [PDF]

Diabetes & Metabolism Journal, 2019
BackgroundWe performed this study to identify factors related to intact incretin levels in patients with type 2 diabetes mellitus (T2DM).MethodsWe cross-sectionally analyzed 336 patients with T2DM.
Soyeon Yoo, Eun-Jin Yang, Gwanpyo Koh
doaj   +1 more source

Thyroxine-binding globulin: investigation of microheterogeneity [PDF]

, 1981
Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland, Henze, R., Horn, K., Pickardt, C. R., Scriba, Peter Christian   +4 more
core   +1 more source

Clinical efficacy and safety of linagliptin in patients with diabetes type 2

Медицинский совет, 2016
Treatment of diabetes mellitus type 2 (T2DM) is a serious challenge which forces to search for new approaches in order to improve the results of pharmacotherapy. Recent advances in diabetology pertain to incretin-directed therapies.
E. V. Biryukova, A. M. Mkrtumyan
doaj   +1 more source

Reagents and models for detecting endogenous GLP1R and GIPR

EBioMedicine, 2021
Glucagon-like peptide-1 receptor (GLP1R) agonists target the GLP1R, whereas dual GLP1R/ gastric inhibitory polypeptide receptor (GIPR) agonists target both the GLP1R and GIPR. Despite the importance of these drug classes for the treatment of diabetes and
Julia Ast, Johannes Broichhagen, David J. Hodson   +2 more
doaj   +1 more source

Daily consumption of monoglucosyl-rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice

Functional Foods in Health and Disease, 2018
Background: Alpha monoglucosyl-rutin (4G-α-D-glucopyranosyl rutin, αMR) has been shown to stimulate antioxidant defenses and anti-glycation. We evaluated the effects of αMR on body weight gain in mice.Methods: Male C57BL/6J mice were divided into four ...
Daigo Yokoyama, Wataru Tanaka, Yushi Hashizume, M. Tandia, M. Sakono, K. Shimoi, H. Sakakibara   +6 more
semanticscholar   +1 more source

Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups

BMC Medical Genetics, 2009
Background Gastric inhibitory polypeptide (GIP) is postulated to be involved in type 2 diabetes mellitus and obesity. It exerts its function through its receptor, GIPR.
Rief Winfried, Reinehr Thomas, Völzke Henry, Rosskopf Dieter, Bornhorst Alexa, Grallert Harald, Wang Hai-Jun, Nguyen Thuy T, Brönner Günter, Scherag André, Vogel Carla IG, Illig Thomas, Wichmann H-Erich, Schäfer Helmut, Hebebrand Johannes, Hinney Anke   +15 more
doaj   +1 more source

Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists [PDF]

, 2017
Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications.
Chantal Chenu, Guillaume Mabilleau, Iepsen, Iepsen, Marie Pereira   +4 more
core   +5 more sources

The Role of Bile in the Regulation of Exocrine Pancreatic Secretion [PDF]

, 1992
As early as 1926 Mellanby (1) was able to show that introduction of bile into the duodenum of anesthetized cats produces a copious flow of pancreatic juice.
Adamczyk W, Andrén-Sandberg A, Aronchick CA, Björnsson OG, Björnsson OG, Brand SJ, Burhol PG, Davies HA, Dragstedt LR, Erlinger S, Eyre-Brook IA, Fausa O, Fiedler F, Forell MM, Forell MM, Forell MM, Forell MM, Forell MM, Frühauf S, Fölsch UR, Geratz JD, Gomez G, Green GM, Gries E, Grundy SM, Hanssen LE, Hartmann W, Hellmann G, Holtermuller KH, Holtermuller KH, Hotz J, Ivy AC, Kataoka K, Konturek SJ, Koop I, Koop I, Koop I, Koop I, Koop I, Kurosawa H, Kuroyanagi Y, Lagerlöf HO, Lehnert P, Lueth HC, Malagelada J-R, Malagelada J-R, Malagelada J-R, Mellanby J, Meyer JH, Miyasaka K, Miyasaka K, Miyasaka K, Miyasaka K, Nakamura R, Nakamura R, Namba M, Nustede R, Ohta H, Osnes M, Osnes M, Osnes M, Osnes M, Otte M, Peter Lehnert, Riepl RL, Riepl RL, Riepl RL, Riepl RL, Rudolf L. Riepl, Schaffalitzky de Muckadell OB, Shiratori K, Smallwood RA, Staub VL, Thomas JE, van Levan H, Wormsley KG   +75 more
core   +1 more source