Results 21 to 30 of about 21,178 (234)
Efficacy and Safety of Tirzepatide in Type 2 Diabetes and Obesity Management
Journal of Obesity & Metabolic Syndrome, 2023 The combination of glucagon-like peptide-1 (GLP-1) with other gut hormones including the glucose-dependent insulinotropic polypeptide (GIP) has been explored to complement and enhance further the GLP-1 effects on glycemia and weight loss.
Rachel Sinha +3 more
doaj +1 more source
Factors Related to Blood Intact Incretin Levels in Patients with Type 2 Diabetes Mellitus [PDF]
Diabetes & Metabolism Journal, 2019 BackgroundWe performed this study to identify factors related to intact incretin levels in patients with type 2 diabetes mellitus (T2DM).MethodsWe cross-sectionally analyzed 336 patients with T2DM.
Soyeon Yoo, Eun-Jin Yang, Gwanpyo Koh
doaj +1 more source
Incretins today: multiple effects and therapeutic potential
Сахарный диабет, 2019 Glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) are the incretin hormones initially discovered in the 1960s. GIP and GLP-1 have gained great scientific interest due to their properties in increasing insulin secretion ...
Oksana V. Tsygankova +2 more
doaj +1 more source
Reagents and models for detecting endogenous GLP1R and GIPR
EBioMedicine, 2021 Glucagon-like peptide-1 receptor (GLP1R) agonists target the GLP1R, whereas dual GLP1R/ gastric inhibitory polypeptide receptor (GIPR) agonists target both the GLP1R and GIPR. Despite the importance of these drug classes for the treatment of diabetes and
Julia Ast +2 more
doaj +1 more source
Journal of Obesity & Metabolic Syndrome, 2023 Obesity is a prevalent global health issue affecting approximately half of the world’s population. Extensive scientific research highlights the urgent need for effective obesity management to mitigate health risks and prevent complications.
Eonju Jeon, Ki Young Lee, Kyoung-Kon Kim
doaj +1 more source
Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
Animal Research and One Health, EarlyView.Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue +10 more
wiley +1 more source
Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy. [PDF]
PLoS ONE, 2014 Islet adaptations to pregnancy were explored in C57BL6/J mice lacking functional receptors for glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP).
R Charlotte Moffett +4 more
doaj +1 more source
Animal Research and One Health, EarlyView.Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang +6 more
wiley +1 more source
npj Systems Biology and ApplicationsGlucagon-like peptide-1 (GLP-1) is a hormone known for its critical functions in managing blood sugar and offering cardiovascular benefits. Our study focuses on Glucagon Like Peptide 1 Receptor (GLP1R) agonists that act beyond glycemic control in ...
Zofia Wicik +7 more
doaj +1 more source