Results 41 to 50 of about 44,547 (282)

Detection of glycated gastric inhibitory polypeptide within the intestines of diabetic obese (ob/ob) mice

, 2001
Gastric inhibitory polypeptide (GIP) is produced within endocrine cells of the small intestine and released into the circulation upon nutrient ingestion.
Abdel-Wahab, YHA, O'Harte, FPM, Abdel-Wahab, Y.H.A., Flatt, P.R., Morgan, LM, Flatt, PR, Mooney, Mark, Morgan, L.M., O'Harte, F.P.M., Mooney, MH   +9 more
core   +1 more source

Circadian rhythm of gastric inhibitory polypeptide (GIP) in man

, 1983
The diurnal variations of serum gastric inhibitory polypeptide (GIP), serum insulin, plasma glucagon, plasma glucose and serum triglycerides were studied for 24 hr in 6 healthy young men, consuming three meals and performing their usual physical ...
Ustra C., Salera M., Capelli M., Miglioli M., Giacomoni P., Giorgi A., Pironi L., Barbara L.   +7 more
core   +1 more source

Approved Anti-Obesity Medications in 2022 KSSO Guidelines and the Promise of Phase 3 Clinical Trials: Anti-Obesity Drugs in the Sky and on the Horizon

Journal of Obesity & Metabolic Syndrome, 2023
Obesity is a prevalent global health issue affecting approximately half of the world’s population. Extensive scientific research highlights the urgent need for effective obesity management to mitigate health risks and prevent complications.
Eonju Jeon, Ki Young Lee, Kyoung-Kon Kim
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy. [PDF]

PLoS ONE, 2014
Islet adaptations to pregnancy were explored in C57BL6/J mice lacking functional receptors for glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP).
R Charlotte Moffett, Srividya Vasu, Bernard Thorens, Daniel J Drucker, Peter R Flatt   +4 more
doaj   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Integrative gene-metabolite network analysis of GLP-1 receptor agonists and related incretin pathways in cardiometabolic health

npj Systems Biology and Applications
Glucagon-like peptide-1 (GLP-1) is a hormone known for its critical functions in managing blood sugar and offering cardiovascular benefits. Our study focuses on Glucagon Like Peptide 1 Receptor (GLP1R) agonists that act beyond glycemic control in ...
Zofia Wicik, Anna Nowak-Szwed, Ceren Eyileten, Harald Sourij, Dirk von Lewinski, Svjatoslavs Kistkins, Joanna Borkowska, Marek Postuła   +7 more
doaj   +1 more source

Identification of Kunitz inhibitor from Cassia obtusifolia L. and its inhibitory effect against Pieris rapae proteases

浙江大学学报. 农业与生命科学版, 2008
A trypsin inhibitor from Cassia obtusifolia seeds, a well known Chinese herb, was isolated to apparent homogeneity by a combination of distilled water extraction, ammonium sulfate precipitation, Sepharose 4B-trypsin affinity and Sephadex G-75 ...
LIAO Hai, REN Wei, ZHAO Xiao-jun, DU Lin-fang   +3 more
doaj   +1 more source

Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia

, 2003
AIMS/HYPOTHESIS: In the isolated perfused pancreas, gastric inhibitory polypeptide (GIP) has been shown to enhance glucagon secretion at basal glucose concentrations, but in healthy humans no glucagonotropic effect of GIP has yet been reported. Therefore,
Nauck, M A, Meier, J J, Holst, Jens Juul, Deacon, C F, Siepmann, N., Schmidt, W.E., Gallwitz, B, Siepmann, N, Deacon, C.F., Meier, J.J., Nauck, M.A., Gallwitz, N., Schmidt, W E   +12 more
core   +1 more source