Results 31 to 40 of about 44,547 (282)
Functional Foods in Health and Disease, 2018 Background: Alpha monoglucosyl-rutin (4G-α-D-glucopyranosyl rutin, αMR) has been shown to stimulate antioxidant defenses and anti-glycation. We evaluated the effects of αMR on body weight gain in mice.Methods: Male C57BL/6J mice were divided into four ...
D. Yokoyama +6 more
semanticscholar +1 more source
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
Angewandte Chemie, EarlyView.We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne +5 more
wiley +2 more sources
Clinical efficacy and safety of linagliptin in patients with diabetes type 2
Медицинский совет, 2016 Treatment of diabetes mellitus type 2 (T2DM) is a serious challenge which forces to search for new approaches in order to improve the results of pharmacotherapy. Recent advances in diabetology pertain to incretin-directed therapies.
E. V. Biryukova, A. M. Mkrtumyan
doaj +1 more source
Journal of Alzheimer's Disease Reports, 2020 Background: Brain insulin resistance and deficiency are well-recognized abnormalities in Alzheimer’s disease (AD) and likely mediators of impaired energy metabolism.
James Robbins +3 more
doaj +1 more source
Efficacy and Safety of Tirzepatide in Type 2 Diabetes and Obesity Management
Journal of Obesity & Metabolic Syndrome, 2023 The combination of glucagon-like peptide-1 (GLP-1) with other gut hormones including the glucose-dependent insulinotropic polypeptide (GIP) has been explored to complement and enhance further the GLP-1 effects on glycemia and weight loss.
Rachel Sinha +3 more
doaj +1 more source
Factors Related to Blood Intact Incretin Levels in Patients with Type 2 Diabetes Mellitus [PDF]
Diabetes & Metabolism Journal, 2019 BackgroundWe performed this study to identify factors related to intact incretin levels in patients with type 2 diabetes mellitus (T2DM).MethodsWe cross-sectionally analyzed 336 patients with T2DM.
Soyeon Yoo, Eun-Jin Yang, Gwanpyo Koh
doaj +1 more source
Gastric inhibitory polypeptide, dietary-induced thermogenesis, and obesity
, 1987 Blood glucose, plasma concentrations of gastric inhibitory polypeptide, insulin, glucagon, Cortisol, and thyroid hormones were measured in nonobese and obese human subjects at 30 and 22 °C ambient temperature (Ta). Oxygen consumption [Formula: see text],
Keith D. Buchanan +3 more
core +1 more source
Incretins today: multiple effects and therapeutic potential
Сахарный диабет, 2019 Glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) are the incretin hormones initially discovered in the 1960s. GIP and GLP-1 have gained great scientific interest due to their properties in increasing insulin secretion ...
Oksana V. Tsygankova +2 more
doaj +1 more source
Reagents and models for detecting endogenous GLP1R and GIPR
EBioMedicine, 2021 Glucagon-like peptide-1 receptor (GLP1R) agonists target the GLP1R, whereas dual GLP1R/ gastric inhibitory polypeptide receptor (GIPR) agonists target both the GLP1R and GIPR. Despite the importance of these drug classes for the treatment of diabetes and
Julia Ast +2 more
doaj +1 more source
Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP [PDF]
, 2009 Aims/hypothesis High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of ...
Isken, Frank +8 more
core +1 more source