Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice. [PDF]
J Diabetes Investig, 2014 Gastric inhibitory polypeptide (GIP) is an incretin secreted from the gastrointestinal tract after an ingestion of nutrients, and stimulates an insulin secretion from the pancreatic islets. Additionally, GIP has important roles in extrapancreatic tissues:
Okawa T +11 more
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Discovery of gastric inhibitory polypeptide and its subsequent fate: Personal reflections. [PDF]
J Diabetes Investig, 2016 The present review focuses initially on experimental studies that were designed to identify acid inhibitory factors, referred to as ‘enterogastrones,’ that ultimately led to the isolation of gastric inhibitory polypeptide (GIP), a 42‐amino acid ...
Pederson RA, McIntosh CH.
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Gastric inhibitory polypeptide immunoneutralization attenuates development of obesity in mice [PDF]
American Journal of Physiology - Endocrinology and Metabolism, 2015 Michael O Boylan, Patricia A Glazebrook
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Radioimmunoassay for Gastric Inhibitory Polypeptide
Gastroenterology, 1974 A specific radioimmunoassay for gastric inhibitory polypeptide has been developed using guinea pig antisera raised to porcine gastric inhibitory polypeptide. Highly purified 125I-porcine gastric inhibitory polypeptide, further purified on Sephadex G-15 after labeling, was employed as a tracer. The sensitivity range is 25 to 250 pg.
M, Kuzio +3 more
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Gastric inhibitory polypeptide receptor methylation in newly diagnosed, drug-naïve patients with type 2 diabetes: a case-control study. [PDF]
PLoS ONE, 2013 GIP action in type 2 diabetic (T2D) patients is altered. We hypothesized that methylation changes could be present in GIP receptor of T2D patients.
Silvia Canivell +9 more
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Hormonal predictors of the insulin sensitive phenotype in humans [PDF]
Biomolecules & BiomedicineClinical obesity, a chronic condition marked by excessive fat accumulation, often leads to insulin resistance and a heightened risk of comorbidities. This study aimed to identify hormonal predictors of an insulin-sensitive phenotype (ISP) in patients ...
Mohamed Badie Ahmed +10 more
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Gastric inhibitory polypeptide receptor antagonist, SKL-14959, suppressed body weight gain on diet-induced obesity mice. [PDF]
Obes Sci Pract, 2018 Gastric inhibitory polypeptide plays a role in glucose and lipid metabolism and is associated with obesity and insulin resistance. The objective of this study is to confirm the anti‐obesity effects of the gastric inhibitory polypeptide receptor ...
Nakamura T +6 more
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Insulin-dependent inhibition of hepatic glycogenolysis by gastric inhibitory polypeptide (GIP) in perfused rat liver [PDF]
Diabetologia, 1986 H Hartmann, W Creutzfeldt
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Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum [PDF]
European Journal of Biochemistry, 1993 Rolf Mentlein +2 more
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