Transcriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptide. [PDF]
Int J Mol Sci, 2014 Apoptosis triggered by exogenous or endogenous stimuli is a crucial phenomenon to determine the fate of neurons, both in physiological and in pathological conditions.
Maino B +3 more
europepmc +3 more sources
Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice. [PDF]
J Diabetes Investig, 2014 Gastric inhibitory polypeptide (GIP) is an incretin secreted from the gastrointestinal tract after an ingestion of nutrients, and stimulates an insulin secretion from the pancreatic islets. Additionally, GIP has important roles in extrapancreatic tissues:
Okawa T +11 more
europepmc +2 more sources
Combined treatment with a gastric inhibitory polypeptide receptor antagonist and a peptidyl peptidase-4 inhibitor improves metabolic abnormalities in diabetic mice [PDF]
Journal of International Medical Research, 2021 Objectives Dipeptidyl peptidase-4 inhibition and gastric inhibitory polypeptide (GIP) receptor antagonism have therapeutic effects in type 2 diabetes mellitus. We assessed the effects of sitagliptin and Pro 3 (GIP) in a mouse model of diabetes.
Fei Yang +3 more
doaj +2 more sources
Gastric inhibitory polypeptide receptor (GIPR) is a promising target for imaging and therapy in neuroendocrine tumors. [PDF]
Surgery, 2013 Background Ligands binding the somatostatin receptor type 2 (SSTR2) are useful for imaging and treatment of neuroendocrine tumors (NETs), but not all tumors express high levels of these receptors.
Sherman SK +5 more
europepmc +2 more sources
Radioimmunoassay for Gastric Inhibitory Polypeptide
Gastroenterology, 1974 A specific radioimmunoassay for gastric inhibitory polypeptide has been developed using guinea pig antisera raised to porcine gastric inhibitory polypeptide. Highly purified 125I-porcine gastric inhibitory polypeptide, further purified on Sephadex G-15 after labeling, was employed as a tracer. The sensitivity range is 25 to 250 pg.
M, Kuzio +3 more
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Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups [PDF]
BMC Medical Genetics, 2009 Background Gastric inhibitory polypeptide (GIP) is postulated to be involved in type 2 diabetes mellitus and obesity. It exerts its function through its receptor, GIPR.
Rief Winfried +15 more
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Gastric inhibitory polypeptide receptor methylation in newly diagnosed, drug-naïve patients with type 2 diabetes: a case-control study. [PDF]
PLoS ONE, 2013 GIP action in type 2 diabetic (T2D) patients is altered. We hypothesized that methylation changes could be present in GIP receptor of T2D patients.
Silvia Canivell +9 more
doaj +2 more sources
First Evaluation of Roux-en-Y Gastric Bypass as a Novel Surgical Treatment for Diabetes and Glucose Metabolism Regulation in Cats [PDF]
Veterinary SciencesObjective: To evaluate the efficacy of Roux-en-Y gastric bypass (RYGB) in improving glucose regulation and metabolic parameters in feline diabetes mellitus (FDM).
Linfeng Li +4 more
doaj +2 more sources
Hormonal predictors of the insulin sensitive phenotype in humans [PDF]
Biomolecules & BiomedicineClinical obesity, a chronic condition marked by excessive fat accumulation, often leads to insulin resistance and a heightened risk of comorbidities. This study aimed to identify hormonal predictors of an insulin-sensitive phenotype (ISP) in patients ...
Mohamed Badie Ahmed +10 more
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