Results 71 to 80 of about 59,555 (264)

Pharmacokinetics, pharmacodynamics and safety of vutiglabridin after multiple oral administrations in healthy female and obese subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee, Hyun Chul Kim, Young Ran Yoon, In‐Jin Jang, Sang‐Ku Yoo, Kyung‐Sang Yu   +5 more
wiley   +1 more source

Rikkunshito prevents blood glucose intolerance in rats undergoing distal pancreatectomy

Endocrine and Metabolic Science
Background: After pancreatic surgery, impaired glucose tolerance may occur as a consequence of surgery, which has the potential to predispose a patient to diabetes.
Hiroshi Kono, Hidetake Amemiya, Naohiro Hosomura, Daisuke Ichikawa   +3 more
doaj   +1 more source

Entero-insular axis in children with simple obesity [PDF]

Pediatric Endocrinology, Diabetes and Metabolism, 2009
Introduction: The entero-insular axis plays an important role in generation ofsatiety signal. Thus, disturbances in this axis can influence the path to a simple obesity.
Jerzy Starzyk, Krystyna Sztefko, Przemysław J. Tomasik   +2 more
doaj  

Gastric Inhibitory Polypeptide Increases Mesenteric Blood Flow

Experimental Biology and Medicine, 1978
SummaryGastric inhibitory polypeptide (GIP) induces dose-dependent increases in superior mesenteric blood flow in the anesthetized cat. There was no concommitant change in systemic arterial pressure or in femoral blood flow indicating a specific decrease in mesenteric vascular resistance.
J W, Fara, A M, Salazar
openaire   +2 more sources

Metabolic effects of secretin [PDF]

, 2013
postprin
Chow, BKC, Sekar, R
core   +1 more source

The novel dual glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 (GLP‐1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long‐acting GLP‐1 receptor agonists

Diabetes, obesity and metabolism, 2020
The effect of dual glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) receptor agonist (RA) tirzepatide on gastric emptying (GE) was compared to that of GLP‐1RAs in non‐clinical and clinical studies.
S. Urva, T. Coskun, C. Loghin, Xuewei Cui, E. Beebe, Libbey S O'Farrell, Daniel A. Briere, C. Benson, M. Nauck, A. Haupt   +9 more
semanticscholar   +1 more source

Buck Wheat: Nutritional, Bioactive Characteristics, Health Benefits, and Side Effects

Future Postharvest and Food, EarlyView.
ABSTRACT Micronutrient deficits have resulted from an over‐reliance on a small number of cereal crops for food security. The agricultural sector faces severe sustainability issues due to the rapid growth of the world's population and sudden climatic changes.
Momina Farooq, Sajad Ahmad Mir, Zahida Naseem   +2 more
wiley   +1 more source

Tirzepatide, GIP(1-42) and GIP(1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354

Frontiers in Pharmacology
Type 2 diabetes (T2D) and obesity are prevalent metabolic disorders affecting millions of individuals worldwide. A new effective therapeutic drug called tirzepatide for the treatment of obesity and T2D is a dual agonist of the GIP receptor and GLP-1 ...
Tayla A. Rees, Tayla A. Rees, Tayla A. Rees, Benjamin J. Buttle, Zoe Tasma, Zoe Tasma, Sung-Hyun Yang, Paul W. R. Harris, Paul W. R. Harris, Paul W. R. Harris, Christopher S. Walker, Christopher S. Walker   +11 more
doaj   +1 more source

Gastric Inhibitory Polypeptide Secretion After Radical Pancreatoduodenectomy

Annals of Surgery, 1984
To elucidate the role of gastric inhibitory polypeptide (GIP) in the alteration of insulin secretion following pancreatoduodenal resection, in which the main sources of GIP are removed, plasma levels of GIP were measured for 180 minutes after oral glucose administration, both before and after radical pancreatoduodenectomy in nine patients with ...
M, Miyata, K, Nakao, Y, Tanaka, T, Sakamoto, M, Hamaji, H, Taketani, Y, Kawashima   +6 more
openaire   +3 more sources

novel insights into the genetics and pathophysiology of adrenocortical tumors [PDF]

, 2015
International audienceAdrenocortical tumors (ACTs) are typically unilateral and can be classified as benign adrenocortical adenomas (ACAs) or malignant adrenocortical cancers (ACCs).
Drougat, Ludivine, Lefèvre, Lucile, Omeiri, Hanin, Ragazzon, Bruno   +3 more
core   +7 more sources