Results 121 to 130 of about 6,216 (159)

Positron Emission Tomography Imaging of Prostate Cancer with Ga-68-Labeled Gastrin-Releasing Peptide Receptor Agonist BBN_7-14 and Antagonist RM26. [PDF]

Bioconjug Chem, 2018
Cheng S, Lang L, Wang Z, Jacobson O, Yung B, Zhu G, Gu D, Ma Y, Zhu X, Niu G, Chen X.   +10 more
europepmc   +1 more source

Dual-Modality Imaging of Prostate Cancer with a Fluorescent and Radiogallium-Labeled Gastrin-Releasing Peptide Receptor Antagonist. [PDF]

J Nucl Med, 2017
Zhang H, Desai P, Koike Y, Houghton J, Carlin S, Tandon N, Touijer K, Weber WA.   +7 more
europepmc   +1 more source

Prospects of Targeting the Gastrin Releasing Peptide Receptor and Somatostatin Receptor 2 for Nuclear Imaging and Therapy in Metastatic Breast Cancer. [PDF]

PLoS One, 2017
Dalm SU, Schrijver WA, Sieuwerts AM, Look MP, Ziel-van der Made AC, de Weerd V, Martens JW, van Diest PJ, de Jong M, van Deurzen CH.   +9 more
europepmc   +1 more source

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Theranostic Prospects of Gastrin-Releasing Peptide Receptor–Radioantagonists in Oncology

PET Clinics, 2017
Gastrin-releasing peptide receptors (GRPRs) represent attractive targets for cancer diagnosis and therapy owing to their overexpression in widespread human tumors. Bombesin (BBN) analogues coupled to suitable chelators for stable radiometal binding have been proposed for diagnostic imaging and radionuclide therapy (theranostics) of GRPR-positive tumors.
Theodosia, Maina, Berthold A, Nock, Harshad, Kulkarni, Aviral, Singh, Richard P, Baum   +4 more
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Gastrin-releasing peptide receptor signaling in the integration of stress and memory

Neurobiology of Learning and Memory, 2014
Neuropeptides act as signaling molecules that regulate a range of aspects of brain function. Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin. GRP acts by binding to the GRP receptor (GRPR, also called BB2), a member of the G-protein coupled receptor (GPCR) superfamily. GRP produced by
Rafael, Roesler, Pamela, Kent, Tatiana, Luft, Gilberto, Schwartsmann, Zul, Merali   +4 more
openaire   +4 more sources

Gastrin-releasing Peptide Receptor Antagonist Effects on an Animal Model of Sepsis

American Journal of Respiratory and Critical Care Medicine, 2006
Abstract Rationale Several new therapeutic strategies have been described for the treatment of sepsis, but to date none are related to alterations in the bombesin/gastrin-releasing peptide (GRP) receptor pathways. Objectives
Felipe, Dal-Pizzol, Luciane Pons, Di Leone, Cristiane, Ritter, Márcio Rodrigo, Martins, Adalisa, Reinke, Daniel, Pens Gelain, Alfeu, Zanotto-Filho, Luiz Fernando, de Souza, Michael, Andrades, Denise Frediani, Barbeiro, Elena Aida, Bernard, Martin, Cammarota, Lia R M, Bevilaqua, Francisco Garcia, Soriano, José, Cláudio, Fonseca, Moreira, Rafael, Roesler, Gilberto, Schwartsmann   +17 more
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Molecular Basis of the Selectivity of Gastrin-Releasing Peptide Receptor for Gastrin-Releasing Peptide

Molecular Pharmacology, 2002
The mammalian bombesin peptides [gastrin-releasing peptide (GRP) and neuromedin B (NMB)] are important in numerous biological and pathological processes. These effects are mediated by the heptahelical GRP receptor (GRPR) and NMB receptor (NMBR). GRP has high affinity for GRPR and lower affinity for NMBR.
Kenji, Tokita, Simon J, Hocart, David H, Coy, Robert T, Jensen   +3 more
openaire   +2 more sources

Analysis of gastrin-releasing peptide gene and gastrin-releasing peptide receptor gene in patients with agoraphobia

Psychiatric Genetics, 2014
A gastrin-releasing peptide receptor (GRPR) knock-out mouse model provided evidence that the gastrin-releasing peptide (GRP) and its neural circuitry operate as a negative feedback-loop regulating fear, suggesting a novel candidate mechanism contributing to individual differences in fear-conditioning and associated psychiatric disorders such as ...
Katrin, Zimmermann, Heike, Görgens, David, Bräuer, Franziska, Einsle, Barbara, Noack, Stephanie, von Kannen, Maria, Grossmann, Jürgen, Hoyer, Alexander, Strobel, Volker, Köllner, Kerstin, Weidner, Andreas, Ziegler, Claudia, Hemmelmann, Hans K, Schackert   +13 more
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Characterization of the detergent solubilized receptor for gastrin-releasing peptide

Peptides, 1990
Properties of detergent solubilized gastrin-releasing peptide receptor were investigated. Swiss 3T3 membranes were covalently labeled with [125I]GRP and homobifunctional cross-linkers. A major labeled protein of 75 kDa was resolved using SDS-polyacrylamide gel electrophoresis.
D, Cirillo, L, Naldini, T W, Moody, P, Comoglio, J, Schlessinger, R, Kris   +5 more
openaire   +2 more sources