Results 141 to 150 of about 6,216 (159)
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Targeting the Bombesin/Gastrin-Releasing Peptide Receptor to Treat Sepsis
Recent Patents on Anti-Infective Drug Discovery, 2007Sepsis is a complex, multifactorial syndrome that can develop into conditions of different severity, described as septic shock or severe sepsis. In spite of the great progress in understanding the mechanisms involved in the pathogenesis and management of sepsis, only a few therapeutic strategies were able to show a decrease in the mortality from septic
Daniela B, Cornelio +3 more
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Expression of Gastrin-Releasing Peptide Receptor Gene in Developing Lung
American Journal of Respiratory Cell and Molecular Biology, 1996Abstract Bombesin (BN) or its mammalian counterpart, Gastrin-releasing peptide (GRP) is produced by pulmonary neuroendocrine cells (PNEC). The function of GRP as a growth factor involves lung morphogenesis, but the precise mechanism and the target cells have not been defined.
D, Wang, H, Yeger, E, Cutz
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Gastrin-Releasing Peptide Receptor as a Molecular Target for Inflammatory Diseases
Inflammation & Allergy-Drug Targets, 2007Bombesin-like peptides (BLP) and its receptors are widely distributed in mammalian peripheral tissues and in the central nervous system. Recently, effects of these peptides on the production and release of cytokines were described both in animal models and humans with inflammatory diseases. Some pathological conditions such as exposure to tobacco smoke,
Fabricia, Petronilho +3 more
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A role for hippocampal gastrin-releasing peptide receptors in extinction of aversive memory
NeuroReport, 2006Although the gastrin-releasing peptide receptor has been implicated in memory consolidation, previous studies have not examined whether it is involved in extinction. Here we show that gastrin-releasing peptide receptor blockade in the hippocampus disrupts extinction of aversive memory.
Tatiana, Luft +5 more
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Overexpression of gastrin-releasing peptide receptor induced layer disorganization in brain
Neuroscience, 2006Gastrin-releasing peptide-preferring and neuromedin B-preferring receptors, members of the bombesin-like peptide receptor subfamily, are reported to regulate proliferation, migration and differentiation. Since they are expressed in developing brain, we postulated that the gastrin-releasing peptide-preferring and neuromedin B-preferring receptors might ...
M, Iwabuchi +3 more
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Expression of gastrin-releasing peptide receptor in patients with cutaneous malignant melanoma
Clinical and Experimental Dermatology, 2013Gastrin-releasing peptide (GRP) is a neuroendocrine peptide shown to possess growth-stimulatory effects in many types of human cancers. High levels of GRP receptors have been found in various types of human cancers, and preclinical studies exploring the therapeutic use of GRP receptor (GRPR) antagonists have been reported, with promising results.
B F, Marrone +4 more
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Expression of Gastrin-releasing Peptide Receptor in Epidermoid Carcinoma of the Anal Canal
Applied Immunohistochemistry & Molecular Morphology, 2014Gastrin-releasing peptide is a neuroendocrine homolog of bombesin that demonstrated important growth-stimulatory effects in various types of cancer. High levels of expression of gastrin-releasing peptide receptors (GRPR) has been found in different malignancies, and the studies exploring the therapeutic use of GRPR antagonists have shown promising ...
Fabíola F, Martins +4 more
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Characterization of receptors for bombesin/gastrin-releasing peptide in human and murine cells
1989Publisher Summary Bombesin (BN), a 14-amino-acid peptide initially isolated from frog skin, and gastrin-releasing peptide (GRP), a 27-amino-acid peptide isolated from porcine stomach tissue, represent one class of peptides biologically active in the mammalian central nervous system (CNS), periphery, and in tumor cells.
T W, Moody +5 more
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