Results 131 to 140 of about 6,216 (159)

Expression of Gastrin-Releasing Peptide Receptors in Endometrial Cancer

Journal of the American College of Surgeons, 2003
The Bombesin (BBS)-related peptide, gastrin-releasing peptide, and its cognate receptor are ectopically expressed by many cancers, in which they regulate tumor proliferation and metastasis. But, their role in endometrial cancers is unknown. The purpose of this study was to determine whether endometrial cancer cell lines express functional BBS receptors
Lyuba, Levine, Joseph A, Licci, Courtney M, Townsend, Mark R, Hellmich   +3 more
openaire   +2 more sources

Gastrin-Releasing Peptide Receptor Expression in Cervical Cancer

Oncology, 2007
<i>Objectives:</i> It was the aim of this study to evaluate whether cervical neoplasms and adjacent tissues express the gastrin-releasing peptide receptor (GRPR) and whether there is a significant difference in its distribution among preinvasive and invasive cancers. <i>Methods:</i> Sections of paraffin-embedded cervical tumors (
Daniela Baumann, Cornelio, Luise, Meurer, Rafael, Roesler, Gilberto, Schwartsmann   +3 more
openaire   +2 more sources

Targeting gastrin-releasing peptide receptors for cancer treatment

Anti-Cancer Drugs, 2004
Growth factor receptors play critical roles in cancer cell proliferation and progression. A number of such receptors have been targeted for cancer treatment by either a monoclonal antibody or a specifically designed small molecule to inhibit the receptor function.
Jiehua, Zhou, Jian, Chen, Michael, Mokotoff, Edward D, Ball   +3 more
openaire   +2 more sources

Bombesin analogues for gastrin-releasing peptide receptor imaging

Nuclear Medicine and Biology, 2012
The present study describes the design and development of a series of new bombesin (BBN) antagonist peptide ligands of the form [(64)Cu-(NO2A-X-D-Phe(6)-BBN(6-13)NHEt)], where Cu-64=a positron emitting radiometal; NO2A=1,4,7-triazacyclononane-1,4-diacetic acid; X=6-amino hexanoic acid, 8-amino octanoic acid or 9-Aminononanoic acid; and BBN(6-13)NHEt ...
Prasant K, Nanda, Usha, Pandey, Brienne N, Bottenus, Tammy L, Rold, Gary L, Sieckman, Ashley F, Szczodroski, Timothy J, Hoffman, Charles J, Smith   +7 more
openaire   +2 more sources

Immunohistochemical localization of gastrin-releasing peptide receptor in the mouse brain

Brain Research, 2005
Gastrin-releasing peptide (GRP) is a mammalian bombesin (BN)-like peptide that binds with high affinity to the GRP receptor (GRP-R). Previous behavioral studies using mice and rats showed that the GRP/GRP-R system mediates learning and memory by modulating neurotransmitter release in the local GABAergic network of the amygdala and the nucleus tractus ...
Sari, Kamichi, Etsuko, Wada, Shunsuke, Aoki, Masayuki, Sekiguchi, Ichiro, Kimura, Keiji, Wada   +5 more
openaire   +2 more sources

Generation and Characterization of Mice Lacking Gastrin-Releasing Peptide Receptor

Biochemical and Biophysical Research Communications, 1997
Gastrin-releasing peptide (GRP) is a mammalian bombesin-like peptide which is widely distributed in the central nervous system as well as in the gastrointestinal tract. GRP binds to its high affinity receptor (GRPR) to elicit a wide spectrum of biological effects on behavior, digestion, and metabolism.
E, Wada, K, Watase, K, Yamada, H, Ogura, M, Yamano, Y, Inomata, J, Eguchi, K, Yamamoto, M E, Sunday, H, Maeno, K, Mikoshiba, H, Ohki-Hamazaki, K, Wada   +12 more
openaire   +2 more sources

A novel peptide targeting gastrin releasing peptide receptor for pancreatic neoplasm detection

Biomaterials Science, 2020
The designed novel peptide GB-6 with targeted GRPR-binding possesses more favorable pharmacokinetic properties and metabolic stability, as well as superior tumor-targeting ability in pancreatic cancer models, relative to BBN 7–14 .
Yuanbiao Tu, Ji Tao, Fang Wang, Peifei Liu, Zhihao Han, Zhaolun Li, Yi Ma, Yueqing Gu   +7 more
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Characterization of the murine pancreatic receptor for gastrin releasing peptide and bombesin

Regulatory Peptides, 1991
The murine pancreatic receptor for bombesin and gastrin releasing peptide (GRP) has been characterized. Analysis of the binding of 125I-GRP to membranes indicates a single class of sites (10(-13) mol/mg protein) with Kd of 43 pM. A 70 kDa membrane protein was cross-linked to 125I-GRP by bis(sulfosuccinimidyl) suberate; labeling was blocked by GRP, GRP (
B O, Fanger, A C, Wade, A D, Cardin
openaire   +2 more sources

Solubilization and Characterization of the Receptor for Gastrin-Releasing Peptide

1993
Publisher Summary Gastrin-releasing peptide (GRP), the mammalian counterpart of bombesin (an amphibian hormone), is a neurohormone that exerts a number of different effects in vivo and in vitro . An autocrine loop involving GRP and its receptor play an important role in the proliferation of small cell carcinoma of the lung .
Richard Kris, Daniela Cirillo, Terry W. Moody, Luigi Naldini   +3 more
openaire   +1 more source

Ets transcriptional regulation of gastrin-releasing peptide receptor in neuroblastomas

Surgery, 2004
We have demonstrated that gastrin-releasing peptide (GRP) binds specifically to its cell surface receptor, GRP-R, to act as an autocrine/paracrine growth factor for neuroblastomas (NBs); an increased expression of GRP-R was found in more advanced-stage NBs.
Jingbo, Qiao, Jeremy, Cree, Junghee, Kang, Sunghoon, Kim, B Mark, Evers, Dai H, Chung   +5 more
openaire   +2 more sources