Results 11 to 20 of about 65,820 (233)

Esophageal Perforation in Zollinger-Ellison Syndrome: A Scoping Review of Management and Outcomes. [PDF]

JGH Open
ABSTRACT Esophageal perforation in Zollinger–Ellison syndrome (ZES) is an exceedingly rare and life‐threatening manifestation of gastrinoma‐related acid hypersecretion. While peptic ulceration and severe reflux are recognized complications of ZES, perforation represents the ultimate consequence of uncontrolled hyperacidity. Evidence remains confined to
Fernicola A, Parmeggiani D, Crocetto F, Calogero A, Cece A, Romano D, Benassai G, Quarto G, Santangelo M.   +8 more
europepmc   +2 more sources

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Safety of Potassium-Competitive Acid Blockers Compared With Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease and Peptic Ulcer Disease: A Systematic Review and Meta-Analysis. [PDF]

J Gastroenterol Hepatol
ABSTRACT Background and Aim Potassium‐competitive acid blockers (P‐CABs) are a novel class of acid suppressants developed to overcome the limitations of proton pump inhibitors (PPIs), providing rapid and sustained acid suppression. While PPI‐related adverse events (AEs) are well‐documented, safety data on P‐CABs remain limited.
Jang Y, Park J, Kang D, Kim JH, Choi HS, Jeon HL, Lee H.   +6 more
europepmc   +2 more sources

Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP) [PDF]

, 2009
Background: Pro-gastrin releasing peptide ( ProGRP) concentrations in blood play an important role in the diagnosis and treatment of patients with small cell lung cancer (SCLC).
Beligere, Gangamani S., Chan, Daniel W., Chan, Sabrina S., Dowell, Barry L., Elliott, Debra, Fujita, Kenju, Hofmann, Karin, Iizuka, Masayuki, Kinukawa, Hideki, Matsuoka, Yoshiharu, Patil, Rahul D., Saegusa, Haruhisa, Sakurai, Yousuke, Scheuer, Cornelia, Sokoll, Lori, Stieber, Petra, Yamaguchi, Ken, Yoshimura, Toru   +17 more
core   +2 more sources

Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH. [PDF]

, 2017
BackgroundGastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation.ObjectiveTo determine whether pre-anesthetic orally administered omeprazole ...
Belafsky, PC, Della Maggiore, A, Fulton, A, Garcia, RS, Marks, SL, Osborn, JM, Pierce, T, Pypendop, BH, Walker, VJ   +8 more
core   +3 more sources

The Role of Pepsinogenes and Some Intestinal Hormones in Pathogenesis of Gastroesophageal Reflux Disease [PDF]

, 2018
80 patients with gastroesophageal reflux disease (GERD) were examined. The diagnosis of GERD was based on the history of the disease, complaints of patients, the results of daily monitoring of pH in the lower third of the esophagus, data of ...
Boichuk, V. (Vira)
core   +2 more sources

The gastric acid pocket is attenuated in H. pylori infected subjects [PDF]

, 2016
Objective Gastric acid secretory capacity in different anatomical regions, including the postprandial acid pocket, was assessed in Helicobacter pylori positive and negative volunteers in a Western population. Design We studied 31 H.
Ballantyne, Stuart A., Derakhshan, Mohammad H., Going, James J., McColl, Kenneth E.L., Mitchell, David R., Orange, Clare, Wirz, Angela A.   +6 more
core   +1 more source

Analytical aspects of gastrin measurement in neuroendocrine tumors

Alʹmanah Kliničeskoj Mediciny, 2018
Rationale: Biochemical diagnostics of neuroendocrine tumors (NETs) is based on the analysis of universal and specific markers, according to the tumor type and clinical manifestations of the disease.
N. V. Lyubimova, T. K. Churikova, Yu. S. Timofeev, T. Yu. Kharitidy, N. E. Kushlinskii   +4 more
doaj   +1 more source

The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1. [PDF]

PLoS ONE, 2013
The hormone gastrin physiologically regulates gastric acid secretion and also contributes to maintaining gastric epithelial architecture by regulating expression of genes such as plasminogen activator inhibitor 2 (PAI-2) and regenerating protein 1 (Reg1).
Adrian O'Hara, Alice Howarth, Andrea Varro, Rod Dimaline   +3 more
doaj   +1 more source

IL1B induced Smad 7 negatively regulates gastrin expression. [PDF]

PLoS ONE, 2011
BACKGROUND: Helicobacter pylori elicited IL1B is one of the various modulators responsible for perturbation of acid secretion in gut. We have earlier reported that IL1B activated NFkB downregulates gastrin, a major modulator of acid secretion.
Dipanjana Datta De, Sumana Bhattacharjya, Meenakshi Maitra, Arindam Datta, Abhijit Choudhury, G K Dhali, Susanta Roychoudhury   +6 more
doaj   +1 more source