NF-kappaB Mediated Transcriptional Repression of Acid Modifying Hormone Gastrin [PDF]
PLoS ONE, 2013 Helicobacter pylori is a major pathogen associated with the development of gastroduodenal diseases. It has been reported that H. pylori induced pro-inflammatory cytokine IL1B is one of the various modulators of acid secretion in the gut.
A Israël +47 more
core +10 more sources
Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway. [PDF]
Adv Sci (Weinh)The Gastrin/CCKBR axis is essential for inhibiting intestinal sodium absorption, but its effects on intestinal glucose metabolism remain elusive. This study aims to determine the role of intestinal Gastrin/CCKBR on glucose absorption in the development ...
Liu X +13 more
europepmc +2 more sources
Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. [PDF]
PLoS ONE, 2013 Neurogenin3(+) (Ngn3(+)) progenitor cells in the developing pancreas give rise to five endocrine cell types secreting insulin, glucagon, somatostatin, pancreatic polypeptide and ghrelin.
Yaron Suissa +12 more
doaj +1 more source
Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis
Molecular Medicine, 2021 Background It is known that increased gastrin concentration is negatively correlated with cardiovascular mortality, and plasma gastrin levels are increased in patients after myocardial infarction (MI).
Jinjuan Fu +5 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Ischemic/reperfusion (I/R) injury is the primary cause of acute kidney injury (AKI). Gastrin, a gastrointestinal hormone, is involved in the regulation of kidney function of sodium excretion. However, whether gastrin has an effect on kidney I/R injury is
Chao Liu +23 more
doaj +1 more source
NR4A2 is regulated by gastrin and influences cellular responses of gastric adenocarcinoma cells. [PDF]
PLoS ONE, 2013 The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the adenocarcinoma cell lines AR42J ...
Kristine Misund +9 more
doaj +1 more source
Evaluation of Two Commercial ELISA Kits for Measuring Equine Serum Gastrin Compared to Radioimmunoassay. [PDF]
Animals (Basel)Gastrin is an important hormone involved in gastric acid secretion. Despite its importance, validated methods other than radioimmunoassay (RIA) to assess serum gastrin concentrations in horses are lacking.
Vokes JR +6 more
europepmc +2 more sources
CHRONIC USE OF PROTON PUMP INHIBITORS AND THE QUANTITY OF G, D, AND ECL CELLS IN THE STOMACH
ABCD: Arquivos Brasileiros de Cirurgia Digestiva, 2020 Background: Acid inhibition from chronic proton pump inhibitor use and a possible increase in gastrin can lead to changes in the regulation of hydrochloric acid production.
Silvia Maria Perrone CAMILO +4 more
doaj +2 more sources
Two distinct aetiologies of cardia cancer, evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status [PDF]
, 2007 Background: Non-cardia gastric adenocarcinoma is positively associated with Helicobacter pylori infection and atrophic gastritis. The role of H pylori infection and atrophic gastritis in cardia cancer is unclear.
Aase, S. +7 more
core +2 more sources
Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH. [PDF]
, 2017 BackgroundGastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation.ObjectiveTo determine whether pre-anesthetic orally administered omeprazole ...
Belafsky, PC +8 more
core +3 more sources