Results 71 to 80 of about 580,716 (298)
Advanced Science, EarlyView.Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan +11 more
wiley +1 more source
, 2023 Dietary fibre has demonstrated benefits against many metabolic diseases such as type 2 diabetes and obesity. Plant cell walls are the primary source of dietary fibre, and the structural integrity largely determines their physiological effects.
Cai, Mingzhu
core +1 more source
Discover FoodNatural bioactive polysaccharides play a crucial role in human health, largely dependent on their digestion in the gastrointestinal tract. Given the complexity and individual variability of the human digestive system, in vitro gastrointestinal digestion ...
Jing-Ya Zeng +5 more
doaj +1 more source
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Persistence of norovirus in static and dynamic simulators of the human gastrointestinal tract
Frontiers in MicrobiologyHuman norovirus (HuNoV), transmitted via the fecal-oral route, is a major cause of gastroenteritis worldwide. However, its persistence during gastrointestinal digestion, particularly in the presence of high-risk food matrices, remains poorly understood ...
Rosie Beaulieu +4 more
doaj +1 more source
Advanced Science, EarlyView.Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang +9 more
wiley +1 more source
Discover FoodIn order to simulate the process of food digestion in the gastrointestinal (GI) tract, various in-vitro digestion models have been developed. These models vary from simple, single-compartment systems to more complex setups with multiple compartments and ...
B. Shiva Kiran +7 more
doaj +1 more source
Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics
Advanced Science, EarlyView.This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li +8 more
wiley +1 more source
Credit authorship contribution statement: Diego Morales: Writing – review & editing, Writing – original draft, Visualization, Investigation, Formal analysis, Data curation, Conceptualization. Amaia Iriondo-DeHond: Writing – original draft, Investigation,
Iriondo De Hond, Amaia +2 more
core +1 more source
Anaerobic digestion of two biodegradable municipal waste streams [PDF]
, 2012 Landfill avoidance for organic wastes is now a high priority worldwide. Two fractions of the municipal waste stream were considered with respect to their potential for diversion through controlled anaerobic digestion. The physical and chemical properties
Zhang, Yue +2 more
core +1 more source