Results 41 to 50 of about 80,923 (291)

Does Hypothyroidism Affect Gastrointestinal Motility?

Gastroenterology Research and Practice, 2009
Background. Gastrointestinal motility and serum thyroid hormone levels are closely related. Our aim was to analyze whether there is a disorder in esophagogastric motor functions as a result of hypothyroidism. Materials and Methods.
Olga Yaylali, Suna Kirac, Mustafa Yilmaz, Fulya Akin, Dogangun Yuksel, Nese Demirkan, Beyza Akdag   +6 more
doaj   +1 more source

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Mucoprotectants and gut barrier: mechanisms of action and clinical applications in IBS. Is there a possible role?

Frontiers in Pharmacology
Impaired gut barrier function plays a pivotal role in the pathophysiology of irritable bowel syndrome (IBS), particularly in IBS with diarrhea. Mucoprotectants, such as xyloglucan, gelatin tannate and pea protein tannins, offer a novel therapeutic ...
Francesco Rettura, Francesco Rettura, Francesco Rettura, Christian Lambiase, Christian Lambiase, Riccardo Tedeschi, Riccardo Tedeschi, Antonio Grosso, Antonio Grosso, Lorenzo Cancelli, Lorenzo Cancelli, Angelo Ricchiuti, Angelo Ricchiuti, Andrea Bottari, Andrea Bottari, Luca Giacomelli, Nicola de Bortoli, Nicola de Bortoli, Massimo Bellini, Massimo Bellini   +19 more
doaj   +1 more source

Real‐World Comparison of High‐Efficacy Versus Non‐High‐Efficacy Therapies in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choice of the first disease modifying treatment (DMT) in multiple sclerosis (MS) is a topic of great interest, and whether high‐efficacy DMTs should be the first choice remains debated. We compared treatment outcomes (no evidence of disease activity [NEDA] and its components) between treatment‐naïve relapsing–remitting MS (RRMS ...
Sarmad Al‐Araji, Marcello Moccia, Alessia Bianchi, Charmaine Yam, Weaam Hamed, Suraya Mohamud, Alan J. Thompson, Frederik Barkhof, Ahmed T. Toosy, Olga Ciccarelli   +9 more
wiley   +1 more source

NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions, with heterogeneous clinical manifestations, including parkinsonism. Recent studies have identified NOTCH2NLC repeat expansions in patients with Parkinson's disease (PD) and atypical parkinsonism (aPM), suggesting ...
Han‐Lin Chiang, Kang‐Yang Jih, Cheng‐Tsung Hsiao, Fu‐Pang Chang, Justus Chunyu Chen, Yi‐Chu Liao, Yih‐Ru Wu, Yi‐Chung Lee   +7 more
wiley   +1 more source

New Insights into the Understanding of Gastrointestinal Dysmotility

Drug Target Insights, 2007
Our understanding of the physiology of digestion, absorption, secretion, and motility in the gastrointestinal tract has improved immensely. Today it is well established that the gross functions of the gastrointestinal tract depend on the coordination ...
Bodil Ohlsson, Sabina Janciauskiene
doaj   +2 more sources

Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway

Journal of Functional Foods, 2016
The effects and underlying molecular mechanisms of allicin on oesophageal squamous cell carcinoma (ESCC) are unclear. Herein, we investigated the effect and action mechanism of allicin in the ESCC cells of Eca-109 and EC9706.
Fenrong Chen, Hong Li, Yan Wang, Meili Gao, Yan Cheng, Dong Liu, Miao Jia, Jun Zhang   +7 more
doaj  

Evaluation of Albizia lebbeck and Curcuma longa Extracts on Gastrointestinal Motility, Safety, and Hematological Parameters: A Sub-Chronic Toxicity and Pharmacological Study [PDF]

Asia Pacific Journal of Medical Toxicology
Background: Gastrointestinal disorders are prevalent worldwide, necessitating effective and safe therapeutic options. The use of herbal medicine dates back thousands of years, with various cultures employing plants to treat ailments.
Bushirat Fagbohun, Hassan Adewuyi, Maryam Musa, Ojochenemi Unuata, Ochonung Ogar, Agor Achi, Usman Mohammed, Jaiyeola Olukayode   +7 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Gastrointestinal Motility Disorders: An Update [PDF]

Digestive Diseases, 2006
Gastrointestinal motility disorders encompass a wide array of signs and symptoms that can occur anywhere throughout the luminal gastrointestinal tract. Motility disorders are often chronic in nature and dramatically affect patients’ quality of life. These prevalent disorders cause a tremendous impact both to the individual patient and to society as a ...
Brian E. Lacy, Kirsten Weiser
openaire   +3 more sources