Results 51 to 60 of about 163,399 (355)

Diclofenac and dexamethasone modulate the effect of cannabidiol on the rat colon motility ex vivo

Journal of Veterinary Research, 2023
Due to the growing interest in the use of cannabinoids in supportive therapies, they are increasingly used together with anti-inflammatory drugs. Cannabinoids inhibit gastrointestinal motility, while steroidal and nonsteroidal anti-inflammatory drugs ...
Chłopecka Magdalena, Kiraga Łukasz, Crowley Kijan, Jank Michał, Latek Urszula, Mendel Marta, Karlik Wojciech   +6 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis

Frontiers in Pharmacology
Irritable bowel syndrome (IBS) is a complex and multifaceted disorder of the gut-brain interaction. Recent evidence suggests that γ-aminobutyric acid (GABA) may be involved in the development of IBS symptoms.
Christian Lambiase, Christian Lambiase, Francesco Rettura, Francesco Rettura, Francesco Rettura, Giusi Desirè Sciumè, Giusi Desirè Sciumè, Riccardo Tedeschi, Riccardo Tedeschi, Antonio Grosso, Antonio Grosso, Lorenzo Cancelli, Lorenzo Cancelli, Andrea Bottari, Andrea Bottari, Matteo Fornai, Luca Antonioli, Nicola de Bortoli, Nicola de Bortoli, Massimo Bellini, Massimo Bellini   +20 more
doaj   +1 more source

Quantitative gastrointestinal function and corresponding symptom profiles in autonomic neuropathy

Frontiers in Neurology, 2022
PurposePeripheral neuropathies with autonomic nervous system involvement are a recognized cause of gastrointestinal dysmotility for a wide spectrum of diseases.
Jordan S. Langford, Eric Tokita, Cecilia Martindale, Leah Millsap, James Hemp, Laura A. Pace, Melissa M. Cortez   +6 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

In vitro effects of three woody plant and sainfoin extracts on two parasitic stage of 3 parasitic nematode species [PDF]

, 2004
Most studies on the effects of tanniferous plants on nematodes have examined forages but have neglected the woody plants. Therefore, in vitro effects of extracts from 3 woody plants (Rubus fructicosus, Quercus robur, Corylus avellana) have been tested on
H., HOSTE, I., FOURASTE, V., PAOLINI
core  

Gigantic Stomach: A Rare Manifestation of Duchenne Muscular Dystrophy [PDF]

, 2019
Duchenne muscular dystrophy (DMD) is characterized by degeneration and atrophy of skeletal, cardiac, and smooth muscles after a latent period of apparently normal development and function. The gastrointestinal manifestations start in the second decade of
Dhaliwal, Amaninder, Dhindsa, Banreet S., Hassen, Getaw W., Madiraju, Sarvani, Rochling, Fedja A.   +4 more
core   +2 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive care.
Amin Mehrabian, Peter Auguste, Amy Grove, Anna Brown, Janette Parr, Mubarak Patel, Furqan Butt, Jeremiah Donoghue, Mehdi Yousefi, Jo Parsons   +9 more
wiley   +1 more source

Impact of Laparoscopic Sleeve Gastrectomy on Gastrointestinal Motility

Gastroenterology Research and Practice, 2018
Objective. Laparoscopic sleeve gastrectomy (LSG) was considered mainly as a restrictive procedure due to anatomic alterations in the upper gastrointestinal tract. Additionally, due to neurohormonal alterations, LSG modifies the gastrointestinal motility,
Eleni Sioka, George Tzovaras, Konstantinos Perivoliotis, Vissarion Bakalis, Eleni Zachari, Dimitrios Magouliotis, Vassiliki Tassiopoulou, Spyridon Potamianos, Andreas Kapsoritakis, Antigoni Poultsidi, Konstantinos Tepetes, Constantine Chatzitheofilou, Dimitris Zacharoulis   +12 more
doaj   +1 more source