Results 101 to 110 of about 285 (135)

Gastroprotection by Nonprostaglandin Substances

1989
Cytoprotection is the term originally introduced into gastrointestinal (GI) pa-thophysiology by Robert to describe the unique feature of prostaglandins (PG) to prevent acute necrotic lesions of the GI mucosa at nonantisecretory doses. This phenomenon has been studied extensively, primarily in experimental animals, and two major categories of ...
Stanislaw J. Konturek, Jan W. Konturek
openaire   +1 more source

Copper-Derivatives and Gastroprotection

1997
The regulation of mucosal microcirculation is involved in maintaining gastric integrity. Limitations to microvascular perfusion, either by direct vasoconstriction or by removal of endogenous vasodilator tone, can lead to the development of mucosal damage, erosion or ulcerations (Whittle, 1981).
G. P. Velo, L. Franco, E. Rizzarelli
openaire   +1 more source

Gastroprotective mechanism of Bauhinia thonningii Schum

Journal of Ethnopharmacology, 2013
Bauhinia thonningii Schum. (Cesalpiniaceae) is locally known as Tambarib and used to treat various diseases including gastric ulcer.The current study aims to evaluate the gastroprotecive mechanism(s) of methanolic (MEBT) and chloroform (CEBT) extracts of Bauhinia thonningii leaves on ethanol-induced gastric ulceration.Gastric acidity, quantification ...
Abdelwahab, S.I., Taha, M.M.E., Abdulla, M.A., Nordin, N., Hadi, A.H.A., Mohan, S., Jayapalan, J.J., Hashim, Onn Haji   +7 more
openaire   +3 more sources

Physiological role of cholecystokinin in gastroprotection in humans

American Journal of Gastroenterology, 1998
Cholecystokinin (CCK) is able to protect gastric mucosa against acute injury in experimental animals but little is known about the role of this hormone in maintaining mucosal integrity in humans. This double-blind, placebo controlled study was performed in 16 healthy volunteers.
J W, Konturek, K, Hengst, S J, Konturek, E, Sito, J, Stachura, W, Domschke   +5 more
openaire   +2 more sources

Gastroprotection by 4-Methylpyrazole Against Ethanol in Humans

Digestive Diseases and Sciences, 1998
4-Methylpyrazole (4-MP), a specific inhibitor of alcohol dehydrogenase, exerts gastroprotection of unusually long duration in rats. We tested the hypothesis that pretreatment with 4-MP might protect the human gastric mucosa against alcohol-induced acute injury.
IAQUINTO G, DEL TACCA M, CUCCURULLO L, PARODI MC, GIARDULLO N, D'ONOFRIO V, NATALE G, CARIGNANI D, FERRARACCIO, Franca, SZABO S.   +9 more
openaire   +4 more sources

Role of prostaglandins in gastroprotection.

Digestive diseases and sciences, 1998
Numerous agents increase gastric mucosal resistance against intraluminal ulcerogens. Although the precise mechanisms of gastroprotection are uncertain, various endogenous mediators involved in gastroprotective effects have been characterized. As prostaglandins exert potent protective effects and inhibition of prostaglandin formation abolishes "adaptive
B M, Peskar, N, Maricic
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Gastroprotective Effect of GABA in Metabolic Stress

Bulletin of Experimental Biology and Medicine
We studied the effect of enteral administration of GABA on the gastric mucosa in male Wistar rats (n=47) with modeled metabolic stress (food deprivation for 9 days with free access to water). The relative weights of the adrenal glands and thymus were determined, and histological examination of the stomach was performed.
N S, Tropskaya, Yu V, Gurman, T S, Popova, A A, Kanibolotsky   +3 more
openaire   +2 more sources

Gastroprotective effect to zine

Digestive Diseases and Sciences, 1994
LAPENNA, Domenico, CUCCURULLO, Franco
openaire   +3 more sources

First Evidence of Gastroprotection by Schinus molle: Roles of Nitric Oxide, Prostaglandins, and Sulfhydryls Groups in Its Mechanism of Action

Molecules, 2022
Daniel Arrieta-Baez, Jesus Arrieta, Yaraset López-Lorenzo   +2 more
exaly  

[Gastroprotective effect of luminal gastrin].

Fiziologicheskii zhurnal, 1992
Experiments on mongrel rats have revealed that ulceration of mucous membrane of the stomach achieved by vinculum of pylorus is formed only in 47% of animals. In this case luminal secretion of gastrin in the rats with unaffected mucous membrane was higher, while the serum secretion--lower than in the rats with injured one.
I L, Popovich, I A, Butusova, S V, Ivasivka   +2 more
openaire   +1 more source