Results 91 to 100 of about 285 (135)
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Mechanisms of Gastroprotection
Scandinavian Journal of Gastroenterology, 1990Gastric mucosa is constantly exposed to various irritants, but it usually maintains its integrity owing to several lines of defense, including mucus-alkaline secretion, mucosal hydrophobicity, rich mucosal blood flow, stabilization of tissue lysosomes, maintenance of mucosal sulfhydryls, and rapid proliferation and renewal of mucosal cells ...
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Veterinary Clinics of North America: Small Animal Practice, 2021
A range of gastroprotective drugs are available for the treatment of esophagitis and gastroduodenal mucosal injury including acid suppressants (ie, histamine-2 receptor antagonists, proton pump inhibitors), coating agents, prostaglandin analogs, and antacids. Of these, the proton pump inhibitors are the most effective drugs for the medical treatment of
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A range of gastroprotective drugs are available for the treatment of esophagitis and gastroduodenal mucosal injury including acid suppressants (ie, histamine-2 receptor antagonists, proton pump inhibitors), coating agents, prostaglandin analogs, and antacids. Of these, the proton pump inhibitors are the most effective drugs for the medical treatment of
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Gastroprotective and Antisecretory Effects of Ebrotidine
Scandinavian Journal of Gastroenterology, 1992This study was designed to assess the gastroprotective and secretory effects of ebrotidine, a novel H2-receptor antagonist, in humans. Two groups (A and B) of male subjects with normal gastric mucosa were used. Group A (six subjects) was treated for 3 days with either ebrotidine or placebo in a randomized, crossover study, and on the 4th day 100 ml of ...
S J, Konturek +5 more
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Role of endogenous gastrin in gastroprotection
European Journal of Pharmacology, 1995Gastrin has a potent influence on gastric acid secretion and mucosal growth but its role in mucosal integrity has been little studied. This study investigated in rats whether gastrin protects the gastric mucosa against the damage by 100% ethanol and what are the possible mechanisms of this protection.
S J, Konturek +3 more
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Thymoquinone: Novel gastroprotective mechanisms
European Journal of Pharmacology, 2012Ample of evidence proved the gastroprotective effect of thymoquinone (TQ), the main constituent of Nigella sativa oil; however, the full mechanistic cassette on the gastric ulcer etiopathogenesis is not fully elucidated. The aim of the present work is to unveil some of the possible mechanisms.
Mahmoud-Awny, Magdy +2 more
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Gastroprotection in neurosurgery: the practice in Great Britain
British Journal of Neurosurgery, 1997The indications for gastroprotection concurrent with corticosteroid use or as prophylaxis for stress ulceration in the neurosurgical intensive care unit remain unclear. The purpose of this study was to determine to what extent gastroprotection is practised in neurosurgical units in the British Isles.
D Rawluk, T A Carroll
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Gastroprotective Effect and Cytotoxicity of Labdenamides
Planta Medica, 2007Some 18 aromatic amides from the labdane diterpenes 15-acetoxyimbricatolic acid and 15-acetoxylabd-8(9)-en-19-oic acid were prepared and assessed for their gastroprotective effect in the HCl/EtOH-induced gastric lesion model in mice. The analysis of the gastroprotective activity of the benzylamides belonging to the series 8(9)- and 8(17)-ene was ...
Izquierdo, R.A. +5 more
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Antisecretory and gastroprotective effects of aescine in rats
General Pharmacology: The Vascular System, 19941. This study was designed to determine the antisecretory effects of aescine in the perfused stomach of the anaesthetized rat. In addition, the effects of aescine on mucosal lesions produced by intragastric instillation of 1 ml of absolute ethanol, its action on the production of mucus and the possible role of PGs in aescine induced gastroprotection ...
E, Marhuenda +2 more
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Eicosanoid and gastroprotection by copper derivatives and NDGA
Inflammation Research, 1995We investigated the effect of oral administration of graded doses of: nordihydroguaiaretic acid (NDGA), CuNSN, a bis(2-benzimidazolyl)thioether and CuCl2 on ethanol-induced gastric damage in the rat and the role of leukotrienes and prostaglandins in attenuating this damage.
L, Franco, G P, Velo
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Gastroprotective activity of Trichosanthes cucumerina in rats
Journal of Ethnopharmacology, 2010The aim of the present study was to scientifically investigate whether Trichosanthes cucumerina Linn (Family: Cucurbitaceae) has gastroprotective activity.All the experiments were conducted using Wistar strain rats (weight: 200-220 g). The food and water given to rats was withdrawn for 36 and 12h respectively, before the commencement of the experiment.
L D A M, Arawwawala +2 more
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