Results 121 to 130 of about 10,115 (192)

Genetic Mechanism That Defines the Characteristic Neurogenesis Patterns in the Neural Plate Using Hes/her Genes During Early Vertebrate Development

genesis, Volume 63, Issue 3, June 2025.
ABSTRACT In the early zebrafish neural plate, proneural cluster domains are defined by surrounding neural progenitor pools (NPPs), generating primary neurogenesis patterns. In each NPP, several Notch‐independent Hes/her‐type genes are expressed in distinct manners.
Takero Ohyanagi, Hiroki Tokizaki, Takehisa Sato, Momo Tsuruoka, Kyo Yamasu   +4 more
wiley   +1 more source

Induction of SOX17 with stimulation of WNT, TGF‐beta, and FGF signaling drives embryonal carcinomas into the yolk‐sac tumor lineage resulting in increased cisplatin resistance

International Journal of Cancer, Volume 156, Issue 11, Page 2210-2224, 1 June 2025.
What's new? Yolk‐sac tumor formation has been suggested to be an escape mechanism during therapy in patients with relapsing germ cell tumors. The molecular mechanisms inducing yolk‐sac tumor development from stem cell‐like precursor embryonal carcinomas remain unclear.
Mara Kotthoff, Margaretha A. Skowron, Felix Bremmer, Fatma Parmaksiz, Pia Kretschmer, Alexa Stephan, Alexander Fichtner, Tobias Lautwein, Katharina Raba, Janina Fuß, Karl Köhrer, Daniel Nettersheim   +11 more
wiley   +1 more source

A single-cell atlas of pig gastrulation as a resource for comparative embryology

Nature Communications
Cell-fate decisions during mammalian gastrulation are poorly understood outside of rodent embryos. The embryonic disc of pig embryos mirrors humans, making them a useful proxy for studying gastrulation.
Luke Simpson, Andrew Strange, Doris Klisch, Sophie Kraunsoe, Takuya Azami, Daniel Goszczynski, Triet Le Minh, Benjamin Planells, Nadine Holmes, Fei Sang, Sonal Henson, Matthew Loose, Jennifer Nichols, Ramiro Alberio   +13 more
doaj   +1 more source

Molluscan Shells, Spicules, and Gladii Are Evolutionarily Deeply Conserved

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 344, Issue 4, Page 198-213, June 2025.
Evolutionarily conserved transcription factor encoding genes and other genes are expressed in the epithelia that give rise to spicules (green) and/or shells (blue) in developmental stages of diverse mollusks, including polyplacophorans, aplacophorans, scaphopods, and cephalopods.
Cristian Camillo Barrera Grijalba, Sonia Victoria Rodríguez Monje, Gabriela Ariza Aranguren, Kathrin Lunzer, Maik Scherholz, Emanuel Redl, Tim Wollesen   +6 more
wiley   +1 more source

De Novo Variant in GBX1 Gene Associated With Developmental Delay and Focal Epilepsy

Molecular Genetics &Genomic Medicine, Volume 13, Issue 6, June 2025.
We first identified an association between the GBX1 gene variant and focal epilepsy, and observed related phenotypes in the gbx1‐Cas9 zebrafish model. ABSTRACT Background The gastrulation brain homeobox (Gbx) family, including GBX1 and GBX2, is crucial for hindbrain development and contributes to the morphogenesis of the midbrain–hindbrain boundary ...
Bingbing Zhang, Xiaohua Li, Xiao Qian, Jihong Tang   +3 more
wiley   +1 more source

Signaling Centers Drive Brachyury Dynamics and Lineage Commitment in mESC Aggregates

FASEB BioAdvances, Volume 7, Issue 6, June 2025.
We used a mouse embryonic stem cell aggregate model to compare the use of Chiron and BMP4 signaling as pulses (applied to the whole aggregate) or signaling centers (applied to part of the aggregate). BMP4 as a pulse was shown to drive neural differentiation, with Chiron inhibiting this effect.
A. Rabeling, M. Goolam
wiley   +1 more source

Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate

Mechanisms of Development, 2020
E. Bardot, A. Hadjantonakis
semanticscholar   +1 more source

Three tissues to gastrulation [PDF]

Nature Methods, 2018
openaire   +3 more sources

Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish[S]

Journal of Lipid Research, 2011
Niemann-Pick disease, type C (NP-C), often associated with Niemann-Pick disease, type C1 (NPC1) mu­tations, is a cholesterol-storage disorder characterized by cellular lipid accumulation, neurodegeneration, and reduced steroid production.
Tyler Schwend, Evyn J. Loucks, Diana Snyder, Sara C. Ahlgren   +3 more
doaj  

PTEN in zebrafish gastrulation

Developmental Biology, 2006
Ariel Finkielsztein, Gregory M. Kelly, Qi Z. Sun, Christopher M. Hillis   +3 more
openaire   +2 more sources