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GATA-3 as a potential therapeutic target for insulin resistance and type 2 diabetes mellitus.
Current Diabetes Reviews, 2020BACKGROUND Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes as it leads to ectopic fat deposition. DISCUSSION The anti-adipogenic transcription factor GATA-3 was identified as
Hend Al-Jaber +2 more
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GATA-3 controls self-renewal in stressed HSCs
Nature Immunology, 2013The transcription factor GATA-3 is expressed in quiescent hematopoietic stem cells (HSCs) with long-term repopulating ability. Stress-mediated activation of HSCs promotes localization of GATA-3 to the nucleus in a manner dependent on the mitogen-activated protein kinase p38α and restricts self-renewal.
Toshimi, Yoshida, Katia, Georgopoulos
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Differential expression of GATA-3 in urothelial carcinoma variants
Human Pathology, 2014GATA binding protein 3 (GATA-3) is a novel immunohistochemical marker for urothelial carcinoma (UC); however, few studies have investigated GATA-3's role as a marker for UC variants. We used immunohistochemistry to assess GATA-3 expression in different UC variants, including micropapillary (n = 46), sarcomatoid (n = 43), small cell carcinoma (n = 22 ...
Yu, Liang +5 more
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Role of GATA-3 in Allergic Diseases
Current Molecular Medicine, 2008GATA-3 is a transcription factor that is specifically expressed in T helper 2 (Th2) cells and plays a critical role in the differentiation of Th2 cells from uncommitted CD4+ lymphocytes. In addition GATA-3 is essential for the gene expression of the cytokines IL-4, IL-5 and IL-13 that mediate allergic inflammation.
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Defective GATA-3 expression in Th2 LCR-deficient mice
Biochemical and Biophysical Research Communications, 2011Th2 cell differentiation is critically influenced by transcription factor GATA-3 and by various cis-acting elements including enhancers, silencers and a locus control region (LCR) in the Th2 cytokine locus. Th2 LCR-deficient Th2 cells completely lost the expression of GATA-3 and the phosphorylation of STAT6.
Soo Seok, Hwang +2 more
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Linking GATA-3 and interleukin-13: implications in asthma
Inflammation Research, 2013Asthma is one of the serious global health problems and cause of huge mortality and morbidity. It is characterized by persistent airway inflammation, airway hyperresponsiveness, increased IgE levels and mucus hypersecretion. Asthma is mediated by dominant Th2 immune response, causing enhanced expression of Th2 cytokines. These cytokines are responsible
Sheikh, Rayees +3 more
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Regulation of Aquaporin-2 Gene Transcription by GATA-3
Biochemical and Biophysical Research Communications, 1997To evaluate the functional role of GATA motifs in the 5'-flanking region of a kidney-specific AQP-2 water channel gene, we sought to isolate a GATA factor(s) expressed in collecting ducts and determined the role on the AQP-2 promoter. Two cDNAs encoding GATA factors were isolated from rat kidney, whose sequences were highly homologous with human GATA-2
S, Uchida +4 more
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Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites
Development, 2000ABSTRACT It is now widely accepted that hemopoietic cells born intraembryonically are the best candidates for the seeding of definitive hemopoietic organs. To further understand the mechanisms involved in the generation of definitive hemopoietic stem cells, we analysed the expression of the hemopoietic-related transcription factors Lmo2 ...
A, Manaia +6 more
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Journal of Immunological Methods, 2003
The differentiation of naive T-helper (Th) cells towards Th1 or Th2 cells is regulated by the transcription factors T-box expressed in T-cells (T-bet) and GATA-binding protein-3 (GATA-3). In the present study, the gene expression of T-bet and GATA-3 was measured by semi-quantitive reverse transcription polymerase chain reaction (RT-PCR) in Th1 and Th2 ...
Habiba, Chakir +4 more
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The differentiation of naive T-helper (Th) cells towards Th1 or Th2 cells is regulated by the transcription factors T-box expressed in T-cells (T-bet) and GATA-binding protein-3 (GATA-3). In the present study, the gene expression of T-bet and GATA-3 was measured by semi-quantitive reverse transcription polymerase chain reaction (RT-PCR) in Th1 and Th2 ...
Habiba, Chakir +4 more
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GATA-3 - not just for Th2 cells anymore.
Cellular & molecular immunology, 2007GATA-3 was first cloned as a T cell specific transcription factor in 1991 and its importance in the transcriptional control of T helper type 2 cell (Th2) differentiation was established in the mid to late 90's. A role for GATA-3 during thymic development has long implied by its continuous and regulated expression through out T lineage development, but ...
I-Cheng, Ho, Sung-Yun, Pai
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