Results 171 to 180 of about 46,185 (207)

GATA-3 as a Marker of Hormone Response in Breast Cancer

Journal of Surgical Research, 2009
GATA-3 is a transcription factor that orchestrates gene expression profiles during embryogenesis of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 has recently been identified as a key player of luminal cell differentiation in the mammary gland ...
Sandy H, Fang, Yizhen, Chen, Ronald J, Weigel   +2 more
openaire   +2 more sources

Regulation of Aquaporin-2 Gene Transcription by GATA-3

Biochemical and Biophysical Research Communications, 1997
To evaluate the functional role of GATA motifs in the 5'-flanking region of a kidney-specific AQP-2 water channel gene, we sought to isolate a GATA factor(s) expressed in collecting ducts and determined the role on the AQP-2 promoter. Two cDNAs encoding GATA factors were isolated from rat kidney, whose sequences were highly homologous with human GATA-2
S, Uchida, Y, Matsumura, T, Rai, S, Sasaki, F, Marumo   +4 more
openaire   +2 more sources

T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3

Journal of Immunological Methods, 2003
The differentiation of naive T-helper (Th) cells towards Th1 or Th2 cells is regulated by the transcription factors T-box expressed in T-cells (T-bet) and GATA-binding protein-3 (GATA-3). In the present study, the gene expression of T-bet and GATA-3 was measured by semi-quantitive reverse transcription polymerase chain reaction (RT-PCR) in Th1 and Th2 ...
Habiba, Chakir, Haiping, Wang, David E, Lefebvre, John, Webb, Fraser W, Scott   +4 more
openaire   +2 more sources

Usefulness of GATA-3 as a marker of seminal epithelium in prostate biopsies

Actas Urológicas Españolas (English Edition), 2017
The incidental presence of seminal vesicle epithelium in prostate needle biopsies is generally recognisable through routine microscopy. However, the biopsy can sometimes be erroneously interpreted as malignant due to its architectural and cytological characteristics, and immunohistochemistry can be useful for correctly identifying the biopsy.
J A, Ortiz-Rey, D, Chantada-de la Fuente, M Á, Peteiro-Cancelo, C, Gómez-de María, M P, San Miguel-Fraile   +4 more
openaire   +2 more sources

Overexpression of GATA-3 Protects against the Development of Hypersensitivity Pneumonitis

American Journal of Respiratory and Critical Care Medicine, 2007
Abstract Rationale Hypersensitivity pneumonitis (HP) is mediated by a Th1 immune response. Transcription factor GATA binding protein-3 (GATA-3) is believed to be a key regulator of Th2 differentiation and thus might play regulatory roles in the pathogenesis of hypersensitivity pneumonitis (HP).
Yosuke, Matsuno, Yukio, Ishii, Keigyou, Yoh, Yuko, Morishima, Norihiro, Haraguchi, Norihiro, Kikuchi, Takashi, Iizuka, Takumi, Kiwamoto, Shinsuke, Homma, Akihiro, Nomura, Tohru, Sakamoto, Morio, Ohtsuka, Nobuyuki, Hizawa, Satoru, Takahashi   +13 more
openaire   +2 more sources

Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites

Development, 2000
ABSTRACT It is now widely accepted that hemopoietic cells born intraembryonically are the best candidates for the seeding of definitive hemopoietic organs. To further understand the mechanisms involved in the generation of definitive hemopoietic stem cells, we analysed the expression of the hemopoietic-related transcription factors Lmo2 ...
A, Manaia, V, Lemarchandel, M, Klaine, I, Max-Audit, P, Romeo, F, Dieterlen-Lièvre, I, Godin   +6 more
openaire   +2 more sources

Expression of GATA-3 in epidermis and hair follicle: Relationship to p63

Biochemical and Biophysical Research Communications, 2007
The epidermis is a multi-layered stratified epithelium continuously renewed by differentiating keratinocytes that develops by the action of p63, a member of the p53 family. The TP63 contains two promoters, resulting in the expression of different proteins, containing (TAp63) or not (DeltaNp63) an amino-terminal transactivation domain, which ...
Chikh A., Sayan E., Thibaut S., Lena A. M., Di Giorgi S., Bernard B. A., MELINO, GENNARO, CANDI, ELEONORA   +7 more
openaire   +3 more sources

GATA-3 Expression as a Predictor of Hormone Response in Breast Cancer

Journal of the American College of Surgeons, 2005
Expression of estrogen receptor-alpha (ERalpha) as determined by immunohistochemistry of tumor tissue is currently the most clinically useful test to predict hormone responsiveness of breast cancer. Thirty percent of ERalpha-positive breast cancers do not respond to hormonal therapy.
Purvi, Parikh, Juan P, Palazzo, Lewis J, Rose, Constantine, Daskalakis, Ronald J, Weigel   +4 more
openaire   +2 more sources

Structure and regulation of the chicken GATA-3 gene.

Journal of biochemistry, 1995
To elucidate the mechanisms underlying the tissue-restricted expression of GATA factor transcription, we have isolated and analyzed the genomic chicken GATA-3 (cGATA-3) locus. Structural analysis of the clones showed that the cGATA-3 gene consists of six exons which span more than 19 kb. Two trans-activating domains and two Zn finger domains of cGATA-3
H, Ishihara, J D, Engel, M, Yamamoto
openaire   +1 more source

The Utility of GATA-3 in the Work-up of Effusions

Journal of the American Society of Cytopathology, 2022
Salih Toker, Aparna Harbhajanka, Claire Michael   +2 more
openaire   +1 more source