Results 71 to 80 of about 18,813,060 (218)

Enforced Expression of GATA-3 Severely Reduces Human Thymic Cellularity [PDF]

The Journal of Immunology, 2001
Abstract Following bone marrow transplantation, patients often suffer from immune incompetence by reduced or late T cell development. Moreover, adult bone marrow stem cells have a lower capacity to generate T cells compared with fetal liver- and umbilical cord blood-derived progenitors.
T, Taghon, M, De Smedt, F, Stolz, M, Cnockaert, J, Plum, G, Leclercq   +5 more
openaire   +2 more sources

Molecular Genetics of T Cell Development [PDF]

, 2005
T cell development is guided by a complex set of transcription factors that act recursively, in different combinations, at each of the developmental choice points from T-lineage specification to peripheral T cell specialization. This review describes the
Aifantis I, Allen JD, Alvarez JD, Anderson MK, Barndt R, Cooper CL, Durum SK, Fisher RC, Gadina M, Hsiang YH, Hsiang YH, Ishiguro A, Ivanov V, Izon DJ, Kishi H, Kohu K, Mao C, McCracken S, McKercher SR, Mullen AC, Nerlov C, Ohteki T, Rosenbauer F, Rothenberg EV, Schilham MW, Sikes ML, Spain LM, Zhang D-H   +27 more
core   +1 more source

Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. [PDF]

PLoS ONE, 2011
Allergic asthma is associated with airway eosinophilia, which is regulated by different T-effector cells. T cells express transcription factors T-bet, GATA-3, RORγt and Foxp3, representing Th1, Th2, Th17 and Treg cells respectively. No study has directly
You Lu, Carina Malmhäll, Margareta Sjöstrand, Madeleine Rådinger, Serena E O'Neil, Jan Lötvall, Apostolos Bossios   +6 more
doaj   +1 more source

GATA-3 transcriptional imprinting in Th2 lymphocytes: A mathematical model [PDF]

Proceedings of the National Academy of Sciences, 2002
Immunological memory involves the fast recall of cytokine expression by T helper (Th) lymphocytes. Two distinct profiles of cytokine expression, Th1 and Th2, can be induced by antigen and polarizing signals during activation of naive Th cells and can subsequently be reexpressed on stimulation by antigen alone.
Thomas, Höfer, Holger, Nathansen, Max, Löhning, Andreas, Radbruch, Reinhart, Heinrich   +4 more
openaire   +2 more sources

A combination of p40, GATA-3 and uroplakin II shows utility in the diagnosis and prognosis of muscle-invasive urothelial carcinoma.

Pathology (Sydney), 2016
Recently developed antibodies against uroplakin II and ΔNp63 (p40) show utility in diagnosing primary bladder urothelial carcinoma, although application in metastatic bladder cancer and patient outcomes has been less well defined.
Mariah Z. Leivo, P. Elson, D. Tacha, B. Delahunt, D. Hansel   +4 more
semanticscholar   +1 more source

Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation. [PDF]

, 2017
Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), represent potentially unlimited cell sources for clinical applications. Previous studies have suggested that hPSCs may benefit from immune privilege and
Allard, Patrick, Chang, Kai-Wei, Chen, Hsin-Fu, Chou, Wen-Hsi, Ghelfi, Elisa, Ho, Hong-Nerng, Huang, Mei-Chi, Jan, Pey-Shynan, Lin, Shau-Ping, Lu, Chen-Yu, Wu, Chia-Eng, Wu, Fang-Chun, Yu, Chen-Wei   +12 more
core   +1 more source

The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4. [PDF]

PLoS ONE, 2013
The cytoplamic junctional proteins cingulin and paracingulin have been implicated in the regulation of gene expression in different cultured cell models.
Laurent Guillemot, Domenica Spadaro, Sandra Citi   +2 more
doaj   +1 more source

Partial Rescue of GATA-3 by Yeast Artificial Chromosome Transgenes

Developmental Biology, 1998
GATA-3 is essential for murine embryonic development, but elucidating the genetic controls over the complex temporal and tissue-specific transcriptional regulatory pattern of this transcription factor gene has been problematic. Here we report the isolation and characterization of two yeast artificial chromosomes (YACs) bearing the murine GATA-3 gene ...
Lakshmanan, G, Lieuw, KH, Grosveld, Frank, Engel, JD   +3 more
openaire   +2 more sources

TCR-Dependent Translational Control of GATA-3 Enhances Th2 Differentiation [PDF]

The Journal of Immunology, 2010
Abstract The differentiation of CD4+ T cells into the Th2 subset is controlled by the transcription factor GATA-3. GATA-3 is both necessary and sufficient for Th2 differentiation and works through the induction of chromatin remodeling at the Th2 effector cytokine loci.
Kevin D, Cook, Jim, Miller
openaire   +2 more sources

GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei [PDF]

, 1999
The GATA-3 transcription factor shows a specific and restricted expression pattern in the developing and adult mouse brain. In the present study we investigated the role of GATA-3 in the caudal raphe system, which is known to operate as a modulator of ...
Doorninck, J.H. (Hikke) van, Goedknegt, E. (Erika), Grosveld, F.G. (Frank), Karis, A. (Alar), Rutteman, M. (Mandy), Wees, J. (Jacqueline) van der, Zeeuw, C.I. (Chris) de   +6 more
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