Results 61 to 70 of about 21,925 (161)

GATA3 haploinsufficiency causes a rapid deterioration of distortion product otoacoustic emissions (DPOAEs) in mice

Neurobiology of Disease, 2005
Human HDR (hypoparathyroidism, deafness and renal dysplasia)-syndrome is caused by haploinsufficiency of zinc-finger transcription factor GATA3. The hearing loss due to GATA3 haploinsufficiency has been shown to be peripheral in origin, but it is unclear
M.A.J. van Looij, H. van der Burg, R.S. van der Giessen, M.M. de Ruiter, J. van der Wees, J.H. van Doorninck, C.I. De Zeeuw, G.A. van Zanten   +7 more
doaj   +1 more source

THE ROLE OF GATA3, FOXA1, ELF5 TRANSCRIPTION FACTORS IN THE PATHOGENESIS AND PROGNOSIS OF BREAST CANCER

Siberian journal of oncology, 2020
Purpose of the study: to review available data on the role and significance of GATA3, FOXA1 and ELF5 transcription factors in the pathogenesis, progression and therapy resistance of breast cancer.Material and Methods. The Medline and PubMed databases were used to identify all studies that evaluated the structure, functional parameters and participation
D. V. Vasilchenko, N. V. Krakhmal, S. V. Vtorushin, M. V. Zavyalova   +3 more
openaire   +3 more sources

Identification of the E3 Deubiquitinase Ubiquitin-specific Peptidase 21 (USP21) as a Positive Regulator of the Transcription Factor GATA3 [PDF]

Journal of Biological Chemistry, 2013
The expression of the transcription factor GATA3 in FOXP3(+) regulatory T (Treg) cells is crucial for their physiological function in limiting inflammatory responses. Although other studies have shown how T cell receptor (TcR) signals induce the up-regulation of GATA3 expression in Treg cells, the underlying mechanism that maintains GATA3 expression in
Jing, Zhang, Chen, Chen, Xiaoxia, Hou, Yayi, Gao, Fang, Lin, Jing, Yang, Zhimei, Gao, Lina, Pan, Lianqin, Tao, Chijun, Wen, Zhengju, Yao, Andy, Tsun, Guochao, Shi, Bin, Li   +13 more
openaire   +2 more sources

Seventeen-Year Journey Working With a Master

Frontiers in Immunology, 2018
It had been a great honor for me to work with the late Dr. William E. Paul for 17 years in the Laboratory of Immunology (LI) from 1998 until his passing in 2015. He was such a master in the immunology field.
Jinfang Zhu
doaj   +1 more source

Comparison of the expression GATA3 in urothelial bladder carcinoma and prostate carcinoma in Hamadan City, West of Iran in 2020

Chronic Diseases Journal
BACKGROUND: Bladder malignancies are a common type of urological cancer leading to a high rate of mortality and morbidity. Bladder cancer is one of the common cancers in the urinary system, which is the 9th cause of cancer in the world.
Esmaeil Sadeghi, Hadi Hossainpour, Mohammad Jafari   +2 more
doaj   +1 more source

Juvenile idiopathic arthritis associated with a mutation in GATA3

Arthritis Research & Therapy, 2019
Background GATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arthritis.
Anna E. Patrick, Wei Wang, Elly Brokamp, Thomas Brent Graham, Thomas M. Aune, Jessica B. Duis   +5 more
doaj   +1 more source

Low expression of GATA3 promotes cell proliferation and metastasis in gastric cancer

Cancer Management and Research, 2017
Shuangqin Wei,1 Liang Zhong,2 Xiaoping Wang,1 Wenju Zhang3 1Department of Gastroenterology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, 2Department of Gastroenterology, Huashan Hospital, Fudan University, 3School of ...
Wei S, Zhong L, Wang X, Zhang W
doaj  

Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway

Molecular Cancer, 2008
Background The transcription factor GATA3 has recently been shown to be necessary for mammary gland morphogenesis and luminal cell differentiation. There is also an increasing body of data linking GATA3 to the estrogen receptor α (ERα) pathway.
Giguère Vincent, Wilson Brian J
doaj   +1 more source

Pioneering new enhancers by GATA3: role of facilitating transcription factors and chromatin remodeling

Nucleic Acids Research
Abstract Pioneer transcription factors (PTFs) bind to inaccessible chromatin and recruit collaborating transcription factors to promote chromatin accessibility. However, mechanisms driving PTFs to specify collaborating transcription factor recruitment and chromatin remodeling remain unclear. Here, we utilize inducible expression of a PTF,
Krystal A Orlando, Sara A Grimm, Paul A Wade   +2 more
openaire   +1 more source

Tfam-mediated metabolic perturbation in RORγt+ lymphocytes impacts intestinal tissue homeostasis and promotes GATA3+RORγt+ innate lymphoid cells

Cell Reports
Summary: Rorc-mediated deletion of Tfam, a mitochondrial transcription factor, causes tuft cell and type 2 immunity-driven small intestine (SI) lengthening in mice. Here, we report an indispensable role for T helper 2 (Th2) cells in this process.
Na Sun, Rupam Paul, Eric Y. Helm, Zong-ming E. Chen, John W. Bostick, Liang Zhou   +5 more
doaj   +1 more source