Results 1 to 10 of about 213,913 (289)

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM

OncoImmunology, 2018
The use of inhibitory checkpoint blockade in the management of glioblastoma has been studied in both preclinical and clinical settings. TIGIT is a novel checkpoint inhibitor recently discovered to play a role in cancer immunity.
Alice L. Hung, Russell Maxwell, Debebe Theodros, Zineb Belcaid, Dimitrios Mathios, Andrew S. Luksik, Eileen Kim, Adela Wu, Yuanxuan Xia, Tomas Garzon-Muvdi, Christopher Jackson, Xiaobu Ye, Betty Tyler, Mark Selby, Alan Korman, Bryan Barnhart, Su-Myeong Park, Je-In Youn, Tamrin Chowdhury, Chul-Kee Park, Henry Brem, Drew M. Pardoll, Michael Lim   +22 more
doaj   +2 more sources

Improving temozolomide biopharmaceutical properties in glioblastoma multiforme (GBM) treatment using GBM-targeting nanocarriers

European Journal of Pharmaceutics and Biopharmaceutics, 2021
Glioblastoma multiforme (GBM) is the most common primary brain cancer. GBM has aggressive development, and the pharmacological treatment remains a challenge due to GBM anatomical characteristics' (the blood-brain barrier and tumor microenvironment) and the increasing resistance to marketed drugs, such as temozolomide (TMZ), the first-line drug for GBM ...
Delello Di Filippo, Leonardo, Hofstätter Azambuja, Juliana, Paes Dutra, Jessyca Aparecida, Tavares Luiz, Marcela, Lobato Duarte, Jonatas, Nicoleti, Luiza Ribeiro, Olalla Saad, Sara Teresinha, Chorilli, Marlus   +7 more
openaire   +5 more sources

Fermi-GBM Discovery of GRB 221009A: An Extraordinarily Bright GRB from Onset to Afterglow [PDF]

Astrophysical Journal Letters, 2023
We report the discovery of GRB 221009A, the highest flux gamma-ray burst (GRB) ever observed by the Fermi Gamma-ray Burst Monitor (Fermi-GBM). This GRB has continuous prompt emission lasting more than 600 s, which smoothly transitions to afterglow ...
S. Lesage, P. Veres, M. Briggs, A. Goldstein, D. Kocevski, E. Burns, C. Wilson-Hodge, P. N. Bhat, D. Huppenkothen, Chris L. Fryer, R. Hamburg, J. Racusin, E. Bissaldi, W. Cleveland, S. Dalessi, C. Fletcher, M. Giles, B. Hristov, C. Hui, B. Mailyan, S. Poolakkil, O. Roberts, A. Kienlin, J. Wood, M. Ajello, M. Arimoto, L. Baldini, J. Ballet, M. Baring, D. Bastieri, J. González, R. Bellazzini, R. Blandford, R. Bonino, P. Bruel, S. Buson, R. Cameron, R. Caputo, P. Caraveo, E. Cavazzuti, G. Chiaro, N. Cibrario, S. Ciprini, P. C. Orestano, M. Crnogorčević, A. Cuoco, S. Cutini, F. Dammando, S. Gaetano, N. D. Lalla, L. Venere, A. Domínguez, S. Fegan, E. Ferrara, H. Fleischhack, Y. Fukazawa, S. Funk, P. Fusco, G. Galanti, V. Gammaldi, F. Gargano, C. Gasbarra, D. Gasparrini, S. Germani, F. Giacchino, N. Giglietto, R. Gill, M. Giroletti, J. Granot, D. Green, I. Grenier, S. Guiriec, M. Gustafsson, E. Hays, J. Hewitt, D. Horan, X. Hou, M. Kuss, L. Latronico, A. Laviron, M. Lemoine-Goumard, J. Li, I. Liodakis, F. Longo, F. Loparco, L. Lorusso, M. Lovellette, P. Lubrano, S. Maldera, A. Manfreda, G. Martí-Devesa, M. Mazziotta, J. Mcenery, I.Mereu, M. Meyer, P. Michelson, T. Mizuno, M. Monzani, A. Morselli, I. Moskalenko, M. Negro, É. Nuss, N. Omodei, E. Orlando, J. Ormes, D. Paneque, G. Panzarini, M. Persic, M. Pesce-Rollins, R. Pillera, F. Piron, H. Poon, T. Porter, G.Principe, S.Raino, R.Rando, B.Rani, M.Razzano, S.Razzaque, A.Reimer, O. Reimer, F. Ryde, M. Sánchez-Conde, P. Parkinson, Lorenzo Scotton, D. Serini, C. Sgro’, V. Sharma, E. Siskind, G. Spandre, P. Spinelli, H. Tajima, D. Torres, J. Valverde, T. Venters, Z. Wadiasingh, K. Wood, G. Zaharijas   +137 more
semanticscholar   +1 more source

The role of celecoxib in glioblastoma treatment: a review of literature [PDF]

World Cancer Research Journal, 2020
Objective: Glioblastoma (GB) is the most aggressive and lethal type of brain tumor. Despite the standard treatments and improvements, the overall survival (OS) and progression free survival (PFS) are not optimal.
F. Tavakolian, S. Sana Khezrnia, M. Dehghani, A. Mansouri   +3 more
doaj   +1 more source

The Madeiran laurel forest endemic Goodyera macrophylla (Orchidaceae) is related to American orchids

Anales del Jardín Botánico de Madrid, 2021
Macaronesian laurel forests harbour many herbs and laurophyllous trees with Mediterranean/European or Macaronesian affinities. Traditionally, the origin of these taxa has been explained by the relict hypothesis interpreting these taxa as relics of ...
Mike Thiv, Manuela Gouveia, Miguel Menezes de Sequeira   +2 more
doaj   +1 more source

Mechanisms of Resistance and Current Treatment Options for Glioblastoma Multiforme (GBM)

Cancers, 2023
Simple Summary Glioblastoma multiforme is one of the hardest-to-treat brain tumors, often resistant to conventional treatments such as chemotherapy and radiation therapy.
Satya Siva Kishan Yalamarty, N. Filipczak, Xiang Li, M. Subhan, F. Parveen, J. Ataide, Bharat Ashok Rajmalani, V. Torchilin   +7 more
semanticscholar   +1 more source

The MiR-561 Suppresses Glioblastoma Cell Proliferation through C-myc Regulation [PDF]

Middle East Journal of Cancer, 2021
Background: Glioblastoma multiforme (GBM) is the most common primary malignat brain tumor in adults. The modulation of miRNA expression is considered both as controlling groundwork for cancer development and invasion and as a potential application in GBM-
Somayeh Karami, Fatemeh Kouhkan, Iman Rad, Nafiseh Tavakolpoor Saleh, Gelareh Shokri, Parviz Fallah, Mehrdad Hashemi   +6 more
doaj   +1 more source

The Fourth Fermi-GBM Gamma-Ray Burst Catalog: A Decade of Data [PDF]

Astrophysical Journal, 2020
We present the fourth in a series of catalogs of gamma-ray bursts (GRBs) observed with Fermi’s Gamma-ray Burst Monitor (Fermi-GBM). It extends the six year catalog by four more years, now covering the 10 year time period from trigger enabling on 2008 ...
A. Kienlin, C. Meegan, W. Paciesas, P. N. Bhat, E. Bissaldi, M. Briggs, E. Burns, W. Cleveland, M. Gibby, M. Giles, A. Goldstein, R. Hamburg, C. Hui, D. Kocevski, B. Mailyan, C. Malacaria, C. Malacaria, S. Poolakkil, R. Preece, O. Roberts, P. Veres, C. Wilson-Hodge   +21 more
semanticscholar   +1 more source

The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, & radiomics

Scientific Data, 2022
Glioblastoma is the most common aggressive adult brain tumor. Numerous studies have reported results from either private institutional data or publicly available datasets. However, current public datasets are limited in terms of: a) number of subjects, b)
S. Bakas, C. Sako, H. Akbari, M. Bilello, Aristeidis Sotiras, G. Shukla, J. Rudie, Natali Flores Santamaría, A. Kazerooni, Sarthak Pati, Saima Rathore, E. Mamourian, S. Ha, William A. Parker, J. Doshi, U. Baid, M. Bergman, Zev A. Binder, R. Verma, R. Lustig, A. Desai, S. Bagley, Z. Mourelatos, J. Morrissette, Christopher D. Watt, S. Brem, R. Wolf, E. Melhem, M. Nasrallah, S. Mohan, D. O’Rourke, C. Davatzikos   +31 more
semanticscholar   +1 more source

microRNAs (miRNAs) in Glioblastoma Multiforme (GBM)—Recent Literature Review

International Journal of Molecular Sciences, 2023
Glioblastoma multiforme (GBM) is the most common, malignant, poorly promising primary brain tumor. GBM is characterized by an infiltrating growth nature, abundant vascularization, and a rapid and aggressive clinical course.
Marianna Makowska, B. Smolarz, H. Romanowicz   +2 more
semanticscholar   +1 more source