Results 51 to 60 of about 213,913 (289)

Dual role of ARPC1B in regulating the network between tumor-associated macrophages and tumor cells in glioblastoma

OncoImmunology, 2022
The tumor microenvironment (TME) plays a critical role in promoting the growth and metastasis of glioblastoma (GBM). Tumor-associated macrophages (TAMs), the most abundant myeloid cells infiltrating in TME, produce proinflammatory cytokines, regulate ...
Tianqi Liu, Chen Zhu, Xin Chen, Jianqi Wu, Gefei Guan, Cunyi Zou, Shuai Shen, Ling Chen, Peng Cheng, Wen Cheng, Anhua Wu   +10 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Clinical and pathological features of anti-glomerular basement membrane disease associated with membranous nephropathy: an observational study

Renal Failure, 2022
To investigate the clinical manifestations, pathological features, pathogenesis, treatment, and prognosis of anti-glomerular basement membrane (anti-GBM) disease with membranous nephropathy (MN).
Shasha Zhang, Chaofan Li, Jing Huang, Yan Zhou, Caifeng Gao, Mengyao Sun, Rong Wang, Bing Chen   +7 more
doaj   +1 more source

MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling

Cell Death and Disease, 2020
Mps one binder 2 (MOB2) regulates the NDR kinase family, however, whether and how it is implicated in cancer remain unknown. Here we show that MOB2 functions as a tumor suppressor in glioblastoma (GBM).
K. Jiang, G. Yao, Lulu Hu, Yumei Yan, Jia Liu, Ji Shi, Youwei Chang, Ye Zhang, Dapeng Liang, Dachuan Shen, Guirong Zhang, Songshu Meng, H. Piao   +12 more
semanticscholar   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Insight into the Progress in CAR-T Cell Therapy and Combination with Other Therapies for Glioblastoma

International Journal of General Medicine, 2023
Tingyu Liang,* Yixuan Song,* Lingui Gu, Yu Wang, Wenbin Ma Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China*These ...
Liang T, Song Y, Gu L, Wang Y, Ma W
doaj  

Fermi GBM GRBs' multivariate statistics [PDF]

Astronomische Nachrichten, 2018
Studying their gamma‐ray spectra may reveal some physical information on γ‐ray bursts (GRBs). The Fermi satellite has observed more than 2,000 GRBs. The FERMIGBRST catalog contains the GRB parameters (peak energy, spectral indices, intensity) estimated for both the total emission (fluence) and the emission during the interval of the peak flux. We found
Racz, Istvan I., Balázs, Lajos G., Bagoly, Zsolt, Horvath, Istvan, Tóth, L. Viktor   +4 more
openaire   +2 more sources

Exploring the Roles of lncRNAs in GBM Pathophysiology and Their Therapeutic Potential

Cells, 2020
Glioblastoma (GBM) remains the most devastating primary central nervous system malignancy with a median survival of around 15 months. The past decades of research have not yielded significant advancements in the treatment of GBM.
C. Stackhouse, G. Gillespie, Christopher D. Willey   +2 more
semanticscholar   +1 more source

Investigation of Oxygen‐Free Wetting Behavior of Aluminum on Copper via Molecular Dynamics Simulations and Experiments

Advanced Engineering Materials, EarlyView.
The wettability of aluminum droplets (Al) on different copper substrates (Cu), where liquid Al spreads on solid Cu surfaces to form a liquid–solid interface, is studied numerically and experimentally. The experimental and numerical results show good agreement in the fast‐spreading regime.
Shan Lyu, Timon Steinhoff, Finn‐Lennard Janthur, Sarah Seffer, Jörg Hermsdorf, Christian Klose, Ludger Overmeyer, Hans‐Jürgen Maier, Nina Merkert   +8 more
wiley   +1 more source

Vortioxetine exhibits anti-glioblastoma activity via the PI3K-Akt signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Glioblastoma multiforme (GBM) presents a significant challenge in oncology due to its highly aggressive nature and inherent resistance to conventional therapeutic interventions.
Huan-Qi Zhang, Dao-Ming Zhang, Zhi-Zhen Huang, Jing Cheng, Chong Zhang, Neng-Ming Lin, Yang-Ling Li   +6 more
doaj   +1 more source