Results 161 to 170 of about 8,559 (195)

Keeping the eIF2 alpha kinase Gcn2 in check [PDF]

Biochimica Et Biophysica Acta - Molecular Cell Research, 2014
The protein kinase Gcn2 is present in virtually all eukaryotes and is of increasing interest due to its involvement in a large array of crucial biological processes.
Evelyn Sattlegger, Rc Silva, Rashmi Ramesh   +2 more
exaly   +4 more sources

Multiple Roles of the Stress Sensor GCN2 in Immune Cells

International Journal of Molecular Sciences, 2023
The serine/threonine-protein kinase general control nonderepressible 2 (GCN2) is a well-known stress sensor that responds to amino acid starvation and other stresses, making it critical to the maintenance of cellular and organismal homeostasis. More than
Yong Zhao, Han Guo, Yangxiao Hou
exaly   +2 more sources

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A new role of GCN2 in the nucleolus

Biochemical and Biophysical Research Communications, 2017
General control nonderepressible 2 (GCN2) is activated by the accumulation of uncharged tRNA in response to amino acid shortage and regulates amino acid starvation response in the cytosol. Here we report the nucleolar localization of GCN2 and the association between GCN2 and small RNA transcripts.
Akito Nakamura
exaly   +3 more sources

GCN2, an old dog with new tricks

Biochemical Society Transactions, 2013
Gcn2 was first described in budding yeast as a serine/threonine protein kinase involved in the response to amino acid starvation and this is its best characterized role to date. Recent work has revealed new and exciting roles for Gcn2, which affect many aspects of cellular physiology in response to a number of stresses in addition to starvation ...
Beáta, Grallert, Erik, Boye
openaire   +2 more sources

GCN2 monitors mRNA translation termination

Molecular Cell
Controlling mRNA translation is critical for proper protein production. Although translation initiation and elongation regulations are becoming increasingly clear, whether and how translation termination is monitored remains poorly understood. Using an acute protein degradation system coupled with phenotypic rescue via ectopic expression, here we show ...
Wenqian Hu
exaly   +3 more sources

GCN2 signalling is dysregulated in pulmonary fibrosis

13.01 - Pulmonary hypertension, 2020
Background: GCN2, a major stress regulator, was recently implicated in pulmonary veno-occlusive disease (Eyries M, et al. Nat Genet 2014 and Perros F, et al. Circulation 2015). This study aims to explore the involvement of the GCN2/eIF2α signalling pathway in the development of pulmonary hypertension (PH) during idiopathic pulmonary fibrosis (IPF), in
D Santos Ribeiro, M Lecocq, M De Beukelaer, C Bouzin, S Verleden, Y Yakoub, R Quarck, F Huaux, H Karmouty-Quintana, S Horman, F Perros, L Godinas, C Pilette   +12 more
openaire   +1 more source

GCN2 in Cancer: Molecular Mechanisms to Therapeutic Potential

Current Cancer Drug Targets
Virtually every mammalian cell contains the cytoplasmic protein kinase General Control Non-depressible 2 (GCN2), which allows cells to cope with stresses such as nutrient shortage. While GCN2 is not essential for normal cells, in many cancers GCN2 assumes a pivotal role, becoming indispensable for cell growth ...
Hayley Prescott, Makhdoom Sarwar, Martin Dickens, Evelyn Sattlegger   +3 more
openaire   +2 more sources

GCN2 activation and eIF2α phosphorylation in the maturation of mouse oocytes

Biochemical and Biophysical Research Communications, 2009
GCN2 is one of the four mammalian kinases that phosphorylate the alpha subunit of the translation initiation factor 2 (eIF2alpha) in a variety of stress situations, resulting in protein synthesis inhibition. GCN2 is involved in regulating metabolism, feeding behavior and memory in rodents. We show here that, relative to other cells, the beta isoform of
Viviane S, Alves, Fabiana L, Motta, Martín, Roffé, Arthur, Delamano, João B, Pesquero, Beatriz A, Castilho   +5 more
openaire   +2 more sources

Genetic evidence for functional specificity of the yeast GCN2 kinase

MGG Molecular & General Genetics, 1996
In yeast the GCN2 kinase mediates translational control of GCN4 by phosphorylating the alpha subunit of eIF-2 in response to extracellular amino acid limitation. Although phosphorylation of eIF-2 alpha has been shown to inhibit global protein synthesis, amino acid starvation results in a specific activation effect on GCN4 mRNA translation.
N. Tavernarakis, G. Thireos, N. Tavernarakis   +2 more
openaire   +2 more sources

GCN2-Mediated Integrated Stress Response Attenuates Periodontitis

Journal of Dental Research
The integrated stress response (ISR), regulated by general control nonderepressible 2 (GCN2), is essential for maintaining tissue homeostasis, yet its role in periodontitis remains poorly understood. Here, through transcriptomic analysis and immunohistochemistry of gingival biopsies from patients and a ligature-induced mouse ...
D. Huang, Q. Li, S. Peng, Y. Li, Q. Yin, X. Yang, X. Gan, Y. Wang, X. Li, Y. Zhao, Y. Guo, W. Lin, Y. Li, N. Feng, Q. Yuan   +14 more
openaire   +2 more sources