Results 151 to 160 of about 8,559 (195)

Immunometabolic Stress and Immune Suppression in Clear-Cell Renal Cell Carcinoma: Perspectives in Therapeutic Strategy. [PDF]

Int J Mol Sci
Nguyen TV, Hsu T.
europepmc   +1 more source

A self-sensing vacuole/lysosome: V-ATPase dysfunction activates selective autophagy. [PDF]

Autophagy
Huang Y, Klionsky DJ.
europepmc   +1 more source

The interaction between GCN2 and eIF2 mediates the resistance of cotton bollworm to the Bacillus thuringiensis Cry1Ac toxin. [PDF]

PLoS Pathog
Zhang C, Wei J, Li N, Naing ZL, Soe ET, Tang J, Yu H, Fang F, Liang G.   +8 more
europepmc   +1 more source

From the integrated stress response to oxidative stress: A historical perspective. [PDF]

J Biol Chem
Amiri M, Toboz P, Bellucci MA, Tahmasebi S, Sonenberg N.   +4 more
europepmc   +1 more source

Activation of the <i>Arabidopsis thaliana</i> GCN2-eIF2α module by salicylic acid: Biochemical and phenotypic similarities between <i>gcn2</i> mutant and wild type. [PDF]

MicroPubl Biol
Wynn M, Lokdarshi A, Diaz DR.
europepmc   +1 more source

A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation. [PDF]

Cell Rep
Mori M, Kauwe G, Aly A, Liao EH, Scott G, Haghighi AP.   +5 more
europepmc   +1 more source

Activation of Gcn2 by small molecules designed to be inhibitors

Journal of Biological Chemistry, 2023
The integrated stress response (ISR) is an important mechanism by which cells confer protection against environmental stresses. Central to the ISR is a collection of related protein kinases that monitor stress conditions, such as Gcn2 (EIF2AK4) that ...
Kirk Staschke, Ronald Wek, Millie Georgiadis   +2 more
exaly   +5 more sources

Activation of GCN2 by the ribosomal P-stalk [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Cells dynamically adjust their protein translation profile to maintain homeostasis in changing environments. During nutrient stress, the kinase general control nonderepressible 2 (GCN2) phosphorylates translation initiation factor eIF2α, initiating the ...
Roger Williams, Ramanujan Hegde, Stephen H Mclaughlin   +2 more
exaly   +6 more sources

Evidence That Eukaryotic Translation Elongation Factor 1A (eEF1A) Binds the Gcn2 Protein C Terminus and Inhibits Gcn2 Activity* [PDF]

Journal of Biological Chemistry, 2011
The eukaryotic elongation factor 1A (eEF1A) delivers aminoacyl-tRNAs to the ribosomal A-site during protein synthesis. To ensure a continuous supply of amino acids, cells harbor the kinase Gcn2 and its effector protein Gcn1. the ultimate signal for amino
Evelyn Sattlegger, Terri Goss Kinzy
exaly   +6 more sources