Results 141 to 150 of about 6,913 (153)

Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis

Cell Stem Cell, 2022
Yishan Li, Shuai Pan
exaly  

Global phosphoproteomics pinpoints uncharted Gcn2-mediated mechanisms of translational control

Molecular Cell, 2021
Michael Stumpe, Benjamin Pillet, Zehan Hu   +2 more
exaly  

The GCN2 / eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity

EMBO Reports, 2023
Romy Timmer, Marina Vietri, Coen Campsteijn   +2 more
exaly  

The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages

Proceedings of the National Academy of Sciences of the United States of America, 2022
Mehdi Amiri, Negar Tabatabaei, Carine Fillebeen   +2 more
exaly  

GCN2

2008
openaire   +1 more source

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

Proceedings of the National Academy of Sciences of the United States of America, 2018
Akito Nakamura, Tadahiro Nambu, Shunsuke Ebara   +2 more
exaly  

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

EMBO Journal, 2001
Hongfang Qiu, Jinsheng Dong, Christopher S Francklyn   +2 more
exaly  

Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

EMBO Journal, 2000
Jinsheng Dong, Alan G Hinnebusch
exaly  

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

Journal of Biological Chemistry, 2017
Wenjie Yuan, Jiaoqi Gao, Gonghong Yan
exaly  

Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode

ACS Medicinal Chemistry Letters, 2019
Jun Fujimoto, Osamu Kurasawa, Terufumi Takagi   +2 more
exaly