Results 141 to 150 of about 7,295 (170)
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Genetic evidence for functional specificity of the yeast GCN2 kinase
MGG Molecular & General Genetics, 1996In yeast the GCN2 kinase mediates translational control of GCN4 by phosphorylating the alpha subunit of eIF-2 in response to extracellular amino acid limitation. Although phosphorylation of eIF-2 alpha has been shown to inhibit global protein synthesis, amino acid starvation results in a specific activation effect on GCN4 mRNA translation.
N. Tavernarakis +2 more
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An In Vitro System to Study Mammalian GCN2 Regulation
General control non-derepressible 2 (GCN2) is an eIF2α kinase responsible for eliciting the integrated stress response (ISR) under amino acid starvation conditions. How GCN2 can sense amino acid starvation and become active in mammalian systems is not fully understood as there are a plethora of protein cofactors and post-translational modifications ...Glenn R. Masson, Vanesa Vinciauskaite
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GCN2-Mediated Integrated Stress Response Attenuates Periodontitis
Journal of Dental ResearchThe integrated stress response (ISR), regulated by general control nonderepressible 2 (GCN2), is essential for maintaining tissue homeostasis, yet its role in periodontitis remains poorly understood. Here, through transcriptomic analysis and immunohistochemistry of gingival biopsies from patients and a ligature-induced mouse ...
D. Huang +14 more
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GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
Cell Metabolism, 2022Romain Riscal +2 more
exaly
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis
Cell Stem Cell, 2022Shuai Pan, Yishan Li, Xiaobin Tian
exaly
Characterisation of Small-Molecule GCN2 Modulators
Diversely derived ATP-competitive inhibitors have shown the ability to paradoxically activate the kinase GCN2. This project investigates clinically approved BRAF inhibitors dabrafenib and encorafenib, that are used as chemotherapeutic treatments for V600E mutant BRAF tumours.openaire +1 more source
Multiple Roles of the Stress Sensor GCN2 in Immune Cells
International Journal of Molecular Sciences, 2023Yong Zhao, Han Guo, Yangxiao Hou
exaly
GCN2 regulation of mTORC2 and mitochondrial metabolism
Highly proliferating cells require substantial nutrient availability to maintain growth and survival. It is important to understand the regulation of nutrient-sensing pathways that are critical for cellular homeostasis. Glutamine is vital in the cell because it serves as a major nitrogen source and alternative carbon source for energy production and ...openaire +1 more source
The role of GCN2 in somatic maintenance and ageing
Ageing is thought to occur because our cells accumulate damage over time. We do not yet know which type of damage is responsible for ageing, but we do know that our diet can affect the rate of damage accumulation and as a result our lifespan. Dietary protein, which is made up of amino acids, is especially important. My research explores how fruit fliesopenaire +1 more source
Global phosphoproteomics pinpoints uncharted Gcn2-mediated mechanisms of translational control
Molecular Cell, 2021Zehan Hu +2 more
exaly