Results 181 to 190 of about 8,559 (195)

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

EMBO Journal, 2001
Christopher S Francklyn, Jinsheng Dong
exaly  

GCN2 MODULATOR FOR TREATING CANCER

2023
BOSE NANDITA, GARGANO MICHELE, IGLESIAS JOSE, MULVIHILL MARK J, OLIVER-SHAFFER PATRICIA, SURGULADZE DAVID, RAMURTHY SAVITHRI, TAMEIRE FEVEN   +7 more
openaire   +1 more source

The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

EMBO Journal, 2010
Costas Koumenis, J Alan, David Ron
exaly  

Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

EMBO Journal, 2000
Jinsheng Dong
exaly  

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

Proceedings of the National Academy of Sciences of the United States of America, 2018
Osamu Kurasawa, Shunsuke Ebara, Tadahiro Nambu   +2 more
exaly  

GCN2 INHIBITORS AND USES THEREOF

2019
BAYLY ANDREW, BLEICH MATTHEW, CHARRIER JEAN-DAMIEN, DODD JAMES, DURRANT STEVEN, ENO MEREDITH SUZANNE, ETXEBARRIA I JARDI GORKA, EVERITT SIMON, FRAYSSE DAMIEN, KELLY SHAZIA, KNEGTEL RONALD, MOCHALKIN IGOR, MORTIMORE MICHAEL, NORTH KIRI, PORICHIS FILIPPOS, PULLIN ROBERT, RUTHERFORD ALISTAIR, STORCK PIERRE-HENRI, TWIN HEATHER CLARE, XIAO YUFANG   +19 more
openaire   +4 more sources

4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS

2021
WHITLOCK GAVIN, FUCHTER MATTHEW
openaire   +2 more sources

General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation

Journal of Neuroimmunology, 2016
Michael Platten, Tobias Lanz, Jana K Sonner   +2 more
exaly  

Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode

ACS Medicinal Chemistry Letters, 2019
Osamu Kurasawa, Tomoya Sameshima, Jun Fujimoto   +2 more
exaly  

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

Journal of Biological Chemistry, 2017
Yapeng Chao, Wenjie Yuan, Yu Jiang
exaly