Results 171 to 180 of about 8,559 (195)
Some of the next articles are maybe not open access.
GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
Cell Metabolism, 2022Romain Riscal +2 more
exaly
Characterisation of Small-Molecule GCN2 Modulators
Diversely derived ATP-competitive inhibitors have shown the ability to paradoxically activate the kinase GCN2. This project investigates clinically approved BRAF inhibitors dabrafenib and encorafenib, that are used as chemotherapeutic treatments for V600E mutant BRAF tumours.openaire +1 more source
GCN2 regulation of mTORC2 and mitochondrial metabolism
Highly proliferating cells require substantial nutrient availability to maintain growth and survival. It is important to understand the regulation of nutrient-sensing pathways that are critical for cellular homeostasis. Glutamine is vital in the cell because it serves as a major nitrogen source and alternative carbon source for energy production and ...openaire +1 more source
The role of GCN2 in somatic maintenance and ageing
Ageing is thought to occur because our cells accumulate damage over time. We do not yet know which type of damage is responsible for ageing, but we do know that our diet can affect the rate of damage accumulation and as a result our lifespan. Dietary protein, which is made up of amino acids, is especially important. My research explores how fruit fliesopenaire +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022
Kostandin Pajcini +2 more
exaly
Kostandin Pajcini +2 more
exaly
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis
Cell Stem Cell, 2022exaly