Results 91 to 100 of about 19,474 (223)

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Properties of neurons derived from induced pluripotent stem cells of Gaucher disease type 2 patient fibroblasts: potential role in neuropathology. [PDF]

PLoS ONE, 2015
Gaucher disease (GD) is caused by insufficient activity of acid β-glucosidase (GCase) resulting from mutations in GBA1. To understand the pathogenesis of the neuronopathic GD, induced pluripotent stem cells (iPSCs) were generated from fibroblasts ...
Ying Sun, Jane Florer, Christopher N Mayhew, Zhanfeng Jia, Zhiying Zhao, Kui Xu, Huimin Ran, Benjamin Liou, Wujuan Zhang, Kenneth D R Setchell, Jianguo Gu, Gregory A Grabowski   +11 more
doaj   +1 more source

GD2-targeting therapy: a comparative analysis of approaches and promising directions

Frontiers in Immunology
Disialoganglioside GD2 is a promising target for immunotherapy with expression primarily restricted to neuroectodermal and epithelial tumor cells. Although its role in the maintenance and repair of neural tissue is well-established, its functions during ...
J. Philippova, J. Shevchenko, Sergey Sennikov   +2 more
semanticscholar   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

SAP-like cells can be enriched by sorting for GD2.

, 2013
(A) A subset of the low-enrichment NCSC-like population expresses GD2. ESC-derived low-enriched NCSC cultures were sorted into GD2− and GD2+ fractions. Left upper panel shows the isotype control, right upper panel the GD2-stained population and the lower
Joachim Wahl (144304), Shobhit Saxena (412007), Markus S. Huber-Lang (85542), Klaus-Michael Debatin (16179), Peter Braubach (412009), Christian Beltinger (144310), Dominic Stadel (412008)   +6 more
core   +1 more source

GD2-mediated impairment of macrophage phagocytosis drives pulmonary metastasis in osteosarcoma

Theranostics
Rationale: The lung is the most common site of metastasis in osteosarcoma, with pulmonary dissemination accounting for most of the disease-related mortality. Despite its clinical significance, the underlying mechanisms is poorly defined.
Yun-Fei He, Peng Yang, P. Ding, Zeng Zhang, Ji-Chuan Wu, Chun-Jie Wang, Guanghui Hou, Jun Ge, Quan Zhou, Zhuo-Run Song, Huilin Yang, Tao Liu, Shun-Yi Lu   +12 more
semanticscholar   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Antibody‐Dependent Cellular Cytotoxicity of iPS Cell‐Derived Natural Killer T Cells by Anti‐GD2 mAb for Neuroblastoma

Cancer Science
While antibody‐dependent cellular cytotoxicity (ADCC) by anti‐disialoganglioside GD2 monoclonal antibody (mAb) has succeeded in increasing the survival rate of high‐risk patients with neuroblastoma, approximately 40%–50% of patients die from the disease.
Katsuhiro Nishimura, T. Aoki, Midori Kobayashi, Mariko Takami, Ko Ozaki, Keita Ogawa, Hongxuan Wang, Daiki Shimizu, Daisuke Katsumi, Hiroko Yoshizawa, Shugo Komatsu, Tomozumi Takatani, Kiyoshi Hirahara, Haruhiko Koseki, T. Hishiki, S. Motohashi   +15 more
semanticscholar   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Long term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy [PDF]

, 2011
Background: The treatment of high-risk neuroblastoma patients consists of multimodal induction therapy to achieve remission followed by consolidation therapy to prevent relapses. However, the type of consolidation therapy is still discussed controversial.
Berthold, Frank, Berthold Frank, Andreas Faldum, Martin Schrappe, Frank Berthold, Handgretinger Rupert, Simon, Thorsten, Barbara Hero, Thomas Klingebiel, Handgretinger, Rupert, Faldum Andreas, Simon Thorsten, Hero, Barbara, Schrappe, Martin, Klingebiel Thomas, Schrappe Martin, Thorsten Simon, Rupert Handgretinger, Hero Barbara, Faldum, Andreas, Klingebiel, Thomas   +20 more
core   +2 more sources