Results 91 to 100 of about 14,298 (222)

Staff Confidence and Barriers to Complex Clinical Communication in Nursing Homes: A Convergent Mixed‐Methods Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To describe all nursing home staff members' confidence in engaging in complex clinical communication with residents and family carers, and to explore factors affecting their attitudes. Methods A convergent mixed‐methods study used questionnaires (n = 288) and 15 group‐based discussions involving 278 professionals across nine nursing homes ...
Silvia Gonella, Eugenia Malinverni, Luciano Orsi, Filippo Laurenti, Stefania Chiodino, Monica Seminara, Simona Operto, Dario Cencio, Marina Sozzi, Giovanna Marsico, Francesca Paruzzo, Mariagrazia Imperato, Jacopo Olagnero, Maria Rivolta, Ilaria Lovetro, Luigi Stella, Valerio Dimonte, Sara Campagna   +17 more
wiley   +1 more source

Therapeutic Induction of Tumor Antigen GD2 in Osteosarcoma [PDF]

Osteosarcoma is the most common primary bone malignancy in children and represents a major challenge in pediatric oncology given its highly aggressive nature. Current therapy consists of a combination of chemotherapy, surgery, and radiation, yet survival
Herman, Samantha
core   +1 more source

Novel anti-GD2 CAR-T cells exhibit superior cytotoxicity against neuroblastoma

European Journal of Inflammation, 2020
Treatment of high-risk paediatric neuroblastoma represents an unmet clinical need. Chimeric antigen receptor-modified T cell (CAR-T) therapy is a promising treatment option, but there exist some challenges regarding specificity and potency.
Cheng ji, Fengtao You, Tingting Zhang, Shuangshuang Fan, Zhichao Han, Shufen Xiang, Yinyan Wang, Binjie Sheng, Tian Wang, Gangli An, Huimin Meng, Lin Yang   +11 more
doaj   +1 more source

CD24 Positive Nucleus Pulposus Cells in Adult Human Intervertebral Discs Maintain a More Notochordal Phenotype Than GD2 Positive Cells

JOR Spine
Background Notochordal cells (NCs) present in the nucleus pulposus (NP) of the developing human intervertebral disc (IVD) disappear during the first decade of life.
Andra‐Maria Ionescu, Pauline Baird, Sonal Patel, Gareth Howell, Judith A. Hoyland, Stephen M. Richardson   +5 more
doaj   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Bridging the Gap in Neuroblastoma Care: Consensus‐Based Statements With Recommendations for Improved Patient and Caregiver Experiences

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger, Joseph Bauer, Jennifer Diamond, Maggie Fader, Shae Hansen, Jacqueline M. Kraveka, Johanna Schoen, Amber Shearer, Dena Sherwood   +8 more
wiley   +1 more source

Engineering anti-GD2 monoclonal antibodies for cancer immunotherapy [PDF]

, 2014
Ganglioside GD2 is highly expressed on neuroectoderm-derived tumors and sarcomas, including neuroblastoma, retinoblastoma, melanoma, small cell lung cancer, brain tumors, osteosarcoma, rhabdomyosarcoma, Ewing’s sarcoma in children and adolescents, as ...
Ahmed, Mahiuddin, Cheung, Nai-Kong V.
core   +1 more source

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs.

PLoS Pathogens, 2017
A genital herpes vaccine is urgently needed to prevent pain and suffering, reduce the incidence of neonatal herpes, and decrease the risk of HIV acquisition and transmission that accompanies genital infection.
Sita Awasthi, Lauren M Hook, Carolyn E Shaw, Bapi Pahar, Jacob A Stagray, David Liu, Ronald S Veazey, Harvey M Friedman   +7 more
doaj   +1 more source

GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma

Journal of Hematology & Oncology, 2020
Background The cure rate for metastatic osteosarcoma has not substantially improved over the past decades. Clinical trials of anti-HER2 trastuzumab or anti-GD2 dinutuximab for metastatic or refractory osteosarcoma were not successful, and neither was ...
Jeong A. Park, Nai-Kong V. Cheung
doaj   +1 more source