Results 71 to 80 of about 13,346 (214)
In silico driven redesign of a clinically relevant antibody for the treatment of GD2 positive tumors. [PDF]
PLoS ONE, 2013 Ganglioside GD2 is a cell surface glycolipid that is highly expressed on cancer cells of neuroectodermal origin, including neuroblastoma, retinoblastoma, melanoma, sarcomas, brain tumors and small cell lung cancer.
Mahiuddin Ahmed +4 more
doaj +1 more source
Frontiers in Oncology, 2023 BackgroundOvarian cancer (OC) is the deadliest gynecological cancer, often diagnosed at advanced stages. A fast and accurate diagnostic method for early-stage OC is needed.
Alba Galan +27 more
doaj +1 more source
Advanced Materials Technologies, EarlyView.The article overviews past and current efforts on caloric materials and systems, highlighting the contributions of Ames National Laboratory to the field. Solid‐state caloric heat pumping is an innovative method that can be implemented in a wide range of cooling and heating applications.
Agata Czernuszewicz +5 more
wiley +1 more source
Anti-GD2 immunoliposomes loaded with oxamate for neuroblastoma
Pediatric Research, 2023 Oncometabolism can be targeted for the development of less myelotoxic oncotherapeutics. Lactate dehydrogenase A (LDHA) is central to the Warburg effect, a potential oncometabolic shift in neuroblastoma (NBL). Advanced surgical, cytotoxic and cell-differentiating therapies improved survival of children with NBL.
William S. Panosyan +3 more
openaire +2 more sources
Viruses, 2022 The toxicity of mRNA-lipid nanoparticle (LNP) vaccines depends on the total mRNA-LNP dose. We established that the maximum tolerated dose of our trivalent mRNA-LNP genital herpes vaccine was 10 μg/immunization in mice. We then evaluated one of the mRNAs,
Lauren M. Hook +9 more
doaj +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Frontiers in Medicine, 2018 The efficacy of T cells expressing chimeric antigen receptors (CARs) for solid tumors has been limited by insufficient CAR T cell expansion and persistence.
Bilal Omer +21 more
doaj +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Mechanism of GD2-induced platelet apoptosis.
, 2014 Both platelets pretreated with blocking anti-Siglec-7 PAb and untreated platelets were incubated with vehicle or GD2. A23187 was used as an apoptosis positive control. Different parameters of apoptosis pathways in platelets were analyzed.
Hind Hamzeh-Cognasse (78447) +8 more
core +1 more source
GD2 Expression in canine primary tumors.
, 2021 Frozen sections of canine tissues labeled with anti-GD2 mAb (clone 14.G2a, a murine IgG2a anti-GD2 mAb) conjugated to PE (red) and counter-stained with DAPI (blue).
Zachary S. Morris (6287090) +17 more
core +1 more source