Results 71 to 80 of about 19,474 (223)

GD2 CAR-T cells in combination with Nivolumab exhibit enhanced antitumor efficacy.

Translational Oncology, 2023
Glioblastoma (GBM) is a common primary brain tumor with poor clinical prognosis. Although CAR-T therapy has been trialed for treatment of GBM, the outcomes are sub-optimal possibly due to exhaustion of T cells and life-threatening neurotoxicity.
Guang-Ji Zhang, Yu Zhao, Zhongfeng Liu, Weihua Liu, Huan-Tong Wu, Xuan Wang, Zhi-Guo Chen   +6 more
semanticscholar   +1 more source

Excitation‐Selective Hydrochromic Upconversion in Zero‐Dimensional Metal Halides

Advanced Science, EarlyView.
Excitation wavelength dictates whether moisture speaks. In zero‐dimensional metal halides, the same humidity leaves the upconversion emission unchanged under 980 nm excitation yet triggers a distinct green‐to‐red shift under 1550 nm. This excitation‐selective hydrochromism, governed by the absorption at each wavelength, enables stimulus‐dependent ...
Joo Hyeong Han, Jeong Min Seo, Sung Woo Jang, Yong Min Park, San Ha Choi, Ji Hyeon Cha, Won Bin Im   +6 more
wiley   +1 more source

GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma. Reply

, 2023
To the Editor: Del Bufalo et al. (April 6 issue)(1) describe the treatment of patients with relapsed or refractory pediatric neuroblastoma with chimeric antigen receptor (CAR)-expressing T cells that target the disialoganglioside GD2 and express the ...
Locatelli F., Locatelli, Franco, Del Bufalo, Francesca, Quintarelli, Concetta   +3 more
core   +1 more source

Key Characteristics and Mechanisms in Ventilator Weaning of Adult Intensive Care Patients-A Qualitative Study With Healthcare Professionals. [PDF]

Nurs Crit Care
ABSTRACT Background Weaning from mechanical ventilation appears to be a complex intervention as defined by the Medical Research Council Framework. However, there is a lack of theoretical insights into ventilator weaning, and the underlying causal mechanisms have not yet been uncovered sufficiently.
Sterr F, Bauernfeind L, Kepplinger A, Rester C, Palm R, Metzing S.   +5 more
europepmc   +2 more sources

Detection of plasma circulating GD2 ganglioside in patients with neuroblastoma and age-matched healthy children. Diagnostic and prognostic evaluation

The Oncologist
Background GD2 ganglioside, a known specific marker for neuroblastoma (NB), exists in different lipoforms, including C18 and C20, which are distinguished by the length of their fatty acid chains.
Martina Morini, S. Barco, Martina Ardito, A. Cafaro, Federica Pigliasco, Lucilla Rossi, Martina Fragola, Daniela Segalerba, Massimo Conte, A. Garaventa, M. Ponzoni, G. Cangemi, M. Corrias   +12 more
semanticscholar   +1 more source

IgA antibody immunotherapy targeting GD2 is effective in preclinical neuroblastoma models

Journal for ImmunoTherapy of Cancer, 2023
Background Immunotherapy targeting GD2 is very effective against high-risk neuroblastoma, though administration of anti-GD2 antibodies induces severe and dose-limiting neuropathic pain by binding GD2-expressing sensory neurons.
Marjolein C. Stip, Mitchell Evers, Maaike Nederend, C. Chan, K. Reiding, M. Damen, A. Heck, S. Koustoulidou, R. Ramakers, G. Krijger, R. de Roos, Edouard Souteyrand, Annelisa M. Cornel, M. Dierselhuis, M. Jansen, M. D. de Boer, T. Valerius, G. van Tetering, J. Leusen, F. Meyer-Wentrup   +19 more
semanticscholar   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Functional activity of anti-GD2 CAR-T cells with different antigen-recognition module

Медицинская иммунология
Neuroblastoma (NB) is the most common extracranial solid tumor in children comprising, 8 to 10% of all pediatric tumors, with incidence of about 1-1.3 cases per 100,000 children under 15 years of age.
D. V. Lutskovich, M. A. Keraz, H. V. Klych, E. S. Lutskovich, A. N. Meleshko   +4 more
doaj   +1 more source

GD2: hopes and challenges for the treatment of pediatric patients with tumors of the central nervous system

npj Precision Oncology
Pediatric Central Nervous System (CNS) tumors are the leading cause of cancer-related death in children, yet effective treatment options remain limited.
Alba Clara Fernández-Rilo, Emmanuel De Billy, G. Del Baldo, B. De Angelis, S. Rossi, F. del Bufalo, C. Quintarelli, F. Locatelli, A. Mastronuzzi, M. Vinci   +9 more
semanticscholar   +1 more source

GM-CSF, G-CSF, or No Cytokine Therapy with Anti-GD2 Immunotherapy for High-Risk Neuroblastoma

International Journal of Cancer, 2023
Colony‐stimulating factors have been shown to improve anti‐disialoganglioside 2 (anti‐GD2) monoclonal antibody response in high‐risk neuroblastoma by enhancing antibody‐dependent cell‐mediated cytotoxicity (ADCC).
J. Mora, S. Modak, Joyce Kinsey, C. Ragsdale, H. Lazarus   +4 more
semanticscholar   +1 more source