Results 51 to 60 of about 13,346 (214)
Pharmaceutics, 2022 Disialoganglioside (GD2) is a subtype of glycolipids that is highly expressed in tumors of neuroectodermal origins, such as neuroblastoma and osteosarcoma.
Fuyuki F. Inagaki +8 more
doaj +1 more source
Anti-GD2 antibody for radiopharmaceutical imaging of osteosarcoma [PDF]
European Journal of Nuclear Medicine and Molecular Imaging, 2022 Abstract Purpose: Osteosarcoma (OS) is the most frequently diagnosed bone cancer in children with little improvement in overall survival in the past decades. The high surface expression of disialoganglioside GD2 on OS tumors and restricted expression in normal tissues makes it an ideal target for anti-OS radiopharmaceuticals.
Yingli Fu +9 more
openaire +2 more sources
, 2017 Aromatase is a critical enzyme in the irreversible conversion of androgens to oestrogens, with inhibition used clinically in hormone-dependent malignancies.
Bryan W Day (7953413) +12 more
core +2 more sources
Journal for ImmunoTherapy of Cancer, 2021 Background Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with no effective standard therapy. Breast cancer stem-like cells (BCSCs) in primary TNBCs are reported to be responsible for metastatic spread of the disease ...
Debasish Tripathy +10 more
doaj +1 more source
Interplay of spin-dependent delocalization and magnetic anisotropy in the ground and excited states of [Gd2@C78]− and [Gd2@C80]− [PDF]
The Journal of Chemical Physics, 2017 The magnetic properties and electronic structure of the ground and excited states of two recently characterized endohedral metallo-fullerenes, [Gd2@C78]− (1) and [Gd2@C80]− (2), have been studied by theoretical methods. The systems can be considered as [Gd2]5+ dimers encapsulated in a fullerene cage with the fifteen unpaired electrons ferromagnetically
Popov, Alexey A. +5 more
openaire +4 more sources
gD2-specific cellular immune responses.
, 2019 Responses to gD2 were determined using PBMCs collected at baseline (week 0), after immunisation (week 9), before booster (week 24) and after booster (week 25).
Julie L. Dutton (8138424) +11 more
core +1 more source
Cellular Physiology and Biochemistry, 2013 Background/Aims: Due to the lack of specific markers, the isolation of pure mesenchymal stem cells (MSCs) from murine bone marrow remains an unsolved problem.
Jie Xu +13 more
doaj +1 more source
Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology. [PDF]
PLoS ONE, 2015 Ganglioside GD2 is a plasma membrane glycosphinogolipid. In healthy adults it is expressed at low levels, but it is over-expressed in many cancers. For cancer therapy, GD2 is targeted with anti-GD2 monoclonal antibodies (mAbs), and one adverse side ...
Wenyong Tong +3 more
doaj +1 more source
Ganglioside GD2 Expression Is Associated With Unfavorable Prognosis in Early Triple-negative Breast Cancer [PDF]
三重大学博士(医学)application/pdfBackground/Aim: Gangliosides (acidic glycosphingolipids) have crucial regulatory roles in normal physiological processes, as well as in pathological conditions, including tumor onset and progression.
東, 千尋 +2 more
core +1 more source
Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]
, 2008 Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K. +12 more
core +1 more source