Results 51 to 60 of about 19,474 (223)

Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1

Nature Cancer, 2022
Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms of resistance to anti-GD2 therapy.
Nathaniel W. Mabe, Min Huang, G. N. Dalton, G. Alexe, Daniel A Schaefer, A. Geraghty, Amanda L. Robichaud, A. Conway, D. Khalid, M. Mader, Julia A. Belk, K. Ross, M. Sheffer, Miles H. Linde, Nghi Ly, Winnie Yao, M. Rotiroti, Benjamin A. H. Smith, Marius Wernig, C. Bertozzi, Michelle Monje, C. Mitsiades, R. Majeti, Ansuman T. Satpathy, K. Stegmaier, R. Majzner   +25 more
semanticscholar   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

DNA vaccine expressing the mimotope of GD2 ganglioside induces protective GD2 cross-reactive antibody responses

, 2005
The GD2 ganglioside expressed on neuroectodermally derived tumors, including neuroblastoma and melanoma, is weakly immunogenic in tumor-bearing patients and induces predominantly immunoglobulin (Ig)-M antibody responses in the immunized host.
Wang, Xinhui, Hanna Rokita, Kozbor, Danuta, Bolesta, Elizabeth, Wierzbicki, Andrzej, Kowalczyk, Aleksandra, Andrzej Wierzbicki, Aleksandra Kowalczyk, Brecher, Martin, Rokita, Hanna, Andrzej Kolinski, Ferrone, Soldano, Piotr Rotkiewicz, Tsao, Chun-Yen, Danuta Kozbor, Martin Brecher, Barbara Bambach, Kolinski, Andrzej, Bambach, Barbara, Rotkiewicz, Piotr, Xinhui Wang, Chun-Yen Tsao, Horwacik, Irena, Irena Horwacik, Elizabeth Bolesta, Soldano Ferrone   +25 more
core   +1 more source

Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine

Viruses, 2022
The toxicity of mRNA-lipid nanoparticle (LNP) vaccines depends on the total mRNA-LNP dose. We established that the maximum tolerated dose of our trivalent mRNA-LNP genital herpes vaccine was 10 μg/immunization in mice. We then evaluated one of the mRNAs,
Lauren M. Hook, Sita Awasthi, Tina M. Cairns, Mohamad-Gabriel Alameh, Bernard T. Fowler, Kevin P. Egan, Molly M. H. Sung, Drew Weissman, Gary H. Cohen, Harvey M. Friedman   +9 more
doaj   +1 more source

GD2 is a Crucial Ganglioside in the Signal Modulation and Application as a Target of Cancer Therapeutics

Cancer Science
While various glycosphingolipids were identified as cancer‐associated carbohydrate antigens to be used as tumor markers, disialylated gangliosides such as GD3 and GD2 have particularly attracted attention from many researchers as promising cancer ...
K. Furukawa, Yuhsuke Ohmi, K. Hamamura, Yuki Ohkawa, Noboru Hashimoto, O. Tajima, K. Kaneko, K. Furukawa   +7 more
semanticscholar   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Predicting GD2 expression across cancer types by the integration of pathway topology and transcriptome data

Frontiers in Bioinformatics
BackgroundThe disialoganglioside GD2 is a key cancer therapy target due to its overexpression in several cancers and limited presence in normal tissues. However, experimental assessment is technically challenging and not routinely available. We developed
Arsenij Ustjanzew, Arsenij Ustjanzew, Arsenij Ustjanzew, Federico Marini, Federico Marini, Federico Marini, Saskia Wagner, Arthur Wingerter, Roger Sandhoff, Jörg Faber, Jörg Faber, Jörg Faber, Claudia Paret, Claudia Paret, Claudia Paret, Claudia Paret, Claudia Paret   +16 more
doaj   +1 more source

Janus Dual Self-Strengthening Structure of Bi2 O3 /Gd2 O3 Nanofibrous Membranes for Superior X-Ray Shielding.

Small, 2023
Bi2 O3 /rare earth oxide biphasic absorbers are attractive for high-efficiency X-ray shielding due to the complementary X-ray absorption effects. However, its application is severely hindered by poor interphasic contact.
Li Xu, Xinyu Zhang, Li-Qian Huang, Jian-Yong Yu, Y. Si, Bin Ding   +5 more
semanticscholar   +1 more source

From the Discovery of the Giant Magnetocaloric Effect to the Development of High‐Power‐Density Systems

Advanced Materials Technologies, EarlyView.
The article overviews past and current efforts on caloric materials and systems, highlighting the contributions of Ames National Laboratory to the field. Solid‐state caloric heat pumping is an innovative method that can be implemented in a wide range of cooling and heating applications.
Agata Czernuszewicz, Yaroslav Mudryk, Jun Cui, Lucas Griffith, Duane D. Johnson, Julie Slaughter   +5 more
wiley   +1 more source

Anti-Gd2 Etoposide-Loaded Immunoliposomes For The Treatment of Gd2 Positive Tumors [PDF]

, 2014
Systemic chemotherapeutics remain the standard of care for most malignancies even though they frequently suffer from narrow therapeutic index, poor serum solubility, and off-target effects.
Brown, Brandon S
core   +1 more source