Results 51 to 60 of about 14,298 (222)

Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine

Viruses, 2022
The toxicity of mRNA-lipid nanoparticle (LNP) vaccines depends on the total mRNA-LNP dose. We established that the maximum tolerated dose of our trivalent mRNA-LNP genital herpes vaccine was 10 μg/immunization in mice. We then evaluated one of the mRNAs,
Lauren M. Hook, Sita Awasthi, Tina M. Cairns, Mohamad-Gabriel Alameh, Bernard T. Fowler, Kevin P. Egan, Molly M. H. Sung, Drew Weissman, Gary H. Cohen, Harvey M. Friedman   +9 more
doaj   +1 more source

Two‐Dimensional Triferroics: From Fundamental Couplings to Multifunctional Applications

Advanced Science, EarlyView.
This graphic summarizes the three main types of currently reported 2D triferroic couplings. From the structural perspective, existing systems can be broadly classified into two categories, which exhibit distinct symmetry features and coupling behaviors. Beyond the lattice difference, a third type involves the interplay among ferroelectricity, magnetism,
Yang Li, Jialin Gong, Zhiqing Li
wiley   +1 more source

Variable Expression of the Disialoganglioside GD2 in Breast Cancer Molecular Subtypes [PDF]

, 2021
The disialoganglioside GD2 is a tumor-associated antigen that may allow for the application of targeted immunotherapies (anti-GD2 antibodies, GD2 CAR T cells) in patients with neuroblastoma and other solid tumors.
Häberle, Lothar, Erber, Ramona, Farwick, Nicole, Andreas Mackensen, Mackensen, Andreas, Laura Landgraf, Paul Gass, Ruebner, Matthias, Sareetha Kailayangiri, Geppert, Carol I., Beckmann, Matthias W., Matthias Ruebner, Nicole Farwick, Kailayangiri, Sareetha, Carol I. Geppert, Hartmann, Arndt, Meyer, Julia, Gass, Paul, Simon Völkl, Matthias W. Beckmann, Schulz-Wendtland, Rüdiger, Hanna Huebner, Julia Meyer, Landgraf, Laura, Huebner, Hanna, Völkl, Simon, Rüdiger Schulz-Wendtland, Peter A. Fasching, Arndt Hartmann, Fasching, Peter A., Ramona Erber, Lothar Häberle, Claudia Rossig, Rossig, Claudia   +33 more
core   +1 more source

Predicting GD2 expression across cancer types by the integration of pathway topology and transcriptome data

Frontiers in Bioinformatics
BackgroundThe disialoganglioside GD2 is a key cancer therapy target due to its overexpression in several cancers and limited presence in normal tissues. However, experimental assessment is technically challenging and not routinely available. We developed
Arsenij Ustjanzew, Arsenij Ustjanzew, Arsenij Ustjanzew, Federico Marini, Federico Marini, Federico Marini, Saskia Wagner, Arthur Wingerter, Roger Sandhoff, Jörg Faber, Jörg Faber, Jörg Faber, Claudia Paret, Claudia Paret, Claudia Paret, Claudia Paret, Claudia Paret   +16 more
doaj   +1 more source

Chimeric Antigen Receptor Signaling Domains Differentially Regulate Proliferation and Native T Cell Receptor Function in Virus-Specific T Cells

Frontiers in Medicine, 2018
The efficacy of T cells expressing chimeric antigen receptors (CARs) for solid tumors has been limited by insufficient CAR T cell expansion and persistence.
Bilal Omer, Bilal Omer, Paul A. Castillo, Haruko Tashiro, Thomas Shum, Mai T. A. Huynh, Mara Cardenas, Miyuki Tanaka, Andrew Lewis, Tim Sauer, Robin Parihar, Robin Parihar, Natalia Lapteva, Michael Schmueck-Henneresse, Malini Mukherjee, Stephen Gottschalk, Stephen Gottschalk, Stephen Gottschalk, Cliona M. Rooney, Cliona M. Rooney, Cliona M. Rooney, Cliona M. Rooney   +21 more
doaj   +1 more source

GD2 and GD3 gangliosides as diagnostic biomarkers for all stages and subtypes of epithelial ovarian cancer

Frontiers in Oncology, 2023
BackgroundOvarian cancer (OC) is the deadliest gynecological cancer, often diagnosed at advanced stages. A fast and accurate diagnostic method for early-stage OC is needed.
Alba Galan, Arturo Papaluca, Arturo Papaluca, Ali Nejatie, Ali Nejatie, Emad Matanes, Emad Matanes, Fouad Brahimi, Wenyong Tong, Wenyong Tong, Ibrahim Yaseen Hachim, Amber Yasmeen, Euridice Carmona, Kathleen Oros Klein, Kathleen Oros Klein, Sonja Billes, Ahmed E. Dawod, Prasad Gawande, Anna Milik Jeter, Anne-Marie Mes-Masson, Anne-Marie Mes-Masson, Celia M. T. Greenwood, Celia M. T. Greenwood, Walter H. Gotlieb, Walter H. Gotlieb, H. Uri Saragovi, H. Uri Saragovi, H. Uri Saragovi   +27 more
doaj   +1 more source

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source

Untersuchung von Anti‐Glykan‐Antikörpern und Erforschung ihres medizinischen Potenzials mithilfe synthetischer Glykane

Angewandte Chemie, EarlyView.
Anti‐Glykan‐Antikörper spielen sowohl bei Gesundheit als auch bei Krankheit eine wesentliche Rolle. Der Zugang zu neuartigen Glykanstrukturen ermöglicht Fortschritte bei der Antikörpercharakterisierung für die Entdeckung von Biomarkern, die Antikörperentwicklung und das Impfstoffdesign.
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

GD2 CAR T cells against human glioblastoma [PDF]

, 2021
Glioblastoma is the most malignant primary brain tumor and is still in need of effective medical treatment. We isolated patient-derived glioblastoma cells showing high GD2 antigen expression representing a potential target for CAR T strategy.
Neri, Giovanni, Spano C., Depenni R., Feletti, Alberto, Di Tinco R., Prapa, Malvina, Petrachi T., Giulia Golinelli, Giuseppe Pugliese, Spano, Carlotta, Giovanni Neri, Massimiliano Dall’Ora, Tiziana Petrachi, Petrachi, Tiziana, Chiavelli, Chiara, Bestagno M., Golinelli, Giulia, Candini, Olivia, Olivia Candini, Golinelli G., Carlotta Spano, Bestagno, Marco, Corrado Iaccarino, Chiara Chiavelli, Di Tinco, Rosanna, Iaccarino, Corrado, Chiavelli C., Neri G., Prapa M., Depenni, Roberta, Grisendi G., Iaccarino C., Malvina Prapa, Rosanna Di Tinco, Laura Bertoni, Pavesi, Giacomo, Pugliese, Giuseppe, Dall'Ora M., Roberta Depenni, Bertoni L., Giulia Grisendi, Giacomo Pavesi, Feletti A., Dall'Ora, Massimiliano, Marco Bestagno, Gianluca Carnevale, Pavesi G., Carnevale G., Dominici M., Candini O., Dominici, Massimo, Grisendi, Giulia, Massimo Dominici, Pugliese G., Alberto Feletti, Bertoni, Laura, Carnevale, Gianluca   +56 more
core   +1 more source

In silico driven redesign of a clinically relevant antibody for the treatment of GD2 positive tumors. [PDF]

PLoS ONE, 2013
Ganglioside GD2 is a cell surface glycolipid that is highly expressed on cancer cells of neuroectodermal origin, including neuroblastoma, retinoblastoma, melanoma, sarcomas, brain tumors and small cell lung cancer.
Mahiuddin Ahmed, Yehuda Goldgur, Jian Hu, Hong-Fen Guo, Nai-Kong V Cheung   +4 more
doaj   +1 more source