Results 61 to 70 of about 13,346 (214)

Overall review of curative impact and barriers of CAR-T cells in osteosarcoma

EXCLI Journal : Experimental and Clinical Sciences
Osteosarcoma (OS) is a rare form of cancer and primary bone malignancy in children and adolescents. Current therapies include surgery, chemotherapy, and amputation.
Guilin Li, Hong Wang, Vafa Meftahpour
doaj   +1 more source

gD2-specific cellular immune responses to COR-1.

, 2019
Responses to gD2 were determined using PBMCs collected at baseline (week 0), after immunisation (week 9), before booster (week 24) and after booster (week 25).
Julie L. Dutton (8138424), Neil Finlayson (8138430), Sally Kinrade (8138427), Julian Druce (4520320), David M. Koelle (8138436), Ian H. Frazer (7418663), Yan Xu (14594), Paul Griffin (3387026), Janin Chandra (3215100), Bo Li (112195), Wai-Ping Woo (466117), Kerry J. Laing (8138433)   +11 more
core   +1 more source

Functional activity of anti-GD2 CAR-T cells with different antigen-recognition module

Медицинская иммунология
Neuroblastoma (NB) is the most common extracranial solid tumor in children comprising, 8 to 10% of all pediatric tumors, with incidence of about 1-1.3 cases per 100,000 children under 15 years of age.
D. V. Lutskovich, M. A. Keraz, H. V. Klych, E. S. Lutskovich, A. N. Meleshko   +4 more
doaj   +1 more source

Anti-GD2 CAR MSCs against metastatic Ewing's sarcoma [PDF]

, 2022
Background: Ewing's sarcoma (ES) is an aggressive cancer affecting children and young adults. We pre-clinically demonstrated that mesenchymal stromal/stem cells (MSCs) can deliver tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) against ...
Casari G., Talami R., D'Amico R., Spano C., Golinelli G., Banchelli F., Nasi M., Dominici M., Dall'Ora M., Candini O., Chiavelli C., Prapa M., Grisendi G., Rossignoli F., Casarini L., Cossarizza A.   +15 more
core   +1 more source

Frequency of ALK and GD2 Expression in Neuroblastoma

Fetal and Pediatric Pathology, 2019
Background: The aim of this study was to elucidate the significance of immunohistochemical staining patterns of ALK and GD2 in peripheral neuroblastic tumors with different stages and favorable/unfavorable features. Materials and methods: 32 neuroblastomas, 7 ganglioneuroblastomas, and 1 ganglioneuroma cases were immunohistochemically stained with ALK ...
Aygün, Zeynep, Batur, Şebnem, Emre, Şenol, Celkan, Tiraje, Ozman, Oktay, Comunoglu, Nil   +5 more
openaire   +2 more sources

Long term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy

, 2011
Background: The treatment of high-risk neuroblastoma patients consists of multimodal induction therapy to achieve remission followed by consolidation therapy to prevent relapses. However, the type of consolidation therapy is still discussed controversial.
Berthold, Frank, Berthold Frank, Andreas Faldum, Martin Schrappe, Frank Berthold, Handgretinger Rupert, Simon, Thorsten, Barbara Hero, Thomas Klingebiel, Handgretinger, Rupert, Faldum Andreas, Simon Thorsten, Hero, Barbara, Schrappe, Martin, Klingebiel Thomas, Schrappe Martin, Thorsten Simon, Rupert Handgretinger, Hero Barbara, Faldum, Andreas, Klingebiel, Thomas   +20 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Targeting disialoganglioside GD2 with chimeric antigen receptor-redirected T cells in lung cancer

, 2022
International audienceBackground We explored whether the disialoganglioside GD2 (GD2) is expressed in small cell lung cancer (SCLC) and non-SCLC (NSCLC) and can be targeted by GD2-specific chimeric antigen receptor (CAR) T cells.
Reppel, Loïc, Tsahouridis, Ourania, Lee, Hong, Weiss, Jared, Pecot, Chad, Savoldo, Barbara, Davis, Ian, Fucà, Giovanni, Dotti, Gianpietro, Akulian, Jason   +9 more
core   +2 more sources

Self‐Cooling Molecular Spin Qudits

Advanced Materials, EarlyView.
A material made of [GdEr] molecular dimers can encode a qudit and perform as a magnetic refrigerant. Microwave resonant pulses coherently manipulate its 16 spin states, while direct demagnetization measurements cool the material and a device down to temperatures below 1 K.
Elías Palacios, David Aguilà, David Gracia, Diamatoula Maniaki, Leoní A. Barrios, Alessandro Chiesa, Jesús I. Martínez, Valentin Novikov, Olivier Roubeau, Stefano Carretta, Marco Evangelisti, Guillem Aromí, Fernando Luis   +12 more
wiley   +1 more source