Results 61 to 70 of about 25,935 (265)

Determination of Trace Levels of Uranium and Thorium in High Purity Gadolinium Sulfate Using ICP-MS with Solid-Phase Chromatographic Extraction Resin

, 2017
The new Super-Kamiokande-Gadolinium (SK-Gd) project is an upgrade of the Super-Kamiokande (SK) detector. In the SK-Gd project, 0.2\% Gd$_2$(SO$_4$)$_3$ is loaded into the 50 kton water tank of the SK.
Ikeda, M., Ito, S., Kishimoto, Y., Takaku, Y.   +3 more
core   +1 more source

From the Discovery of the Giant Magnetocaloric Effect to the Development of High‐Power‐Density Systems

Advanced Materials Technologies, EarlyView.
The article overviews past and current efforts on caloric materials and systems, highlighting the contributions of Ames National Laboratory to the field. Solid‐state caloric heat pumping is an innovative method that can be implemented in a wide range of cooling and heating applications.
Agata Czernuszewicz, Yaroslav Mudryk, Jun Cui, Lucas Griffith, Duane D. Johnson, Julie Slaughter   +5 more
wiley   +1 more source

In silico driven redesign of a clinically relevant antibody for the treatment of GD2 positive tumors. [PDF]

PLoS ONE, 2013
Ganglioside GD2 is a cell surface glycolipid that is highly expressed on cancer cells of neuroectodermal origin, including neuroblastoma, retinoblastoma, melanoma, sarcomas, brain tumors and small cell lung cancer.
Mahiuddin Ahmed, Yehuda Goldgur, Jian Hu, Hong-Fen Guo, Nai-Kong V Cheung   +4 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Chimeric Antigen Receptor Signaling Domains Differentially Regulate Proliferation and Native T Cell Receptor Function in Virus-Specific T Cells

Frontiers in Medicine, 2018
The efficacy of T cells expressing chimeric antigen receptors (CARs) for solid tumors has been limited by insufficient CAR T cell expansion and persistence.
Bilal Omer, Bilal Omer, Paul A. Castillo, Haruko Tashiro, Thomas Shum, Mai T. A. Huynh, Mara Cardenas, Miyuki Tanaka, Andrew Lewis, Tim Sauer, Robin Parihar, Robin Parihar, Natalia Lapteva, Michael Schmueck-Henneresse, Malini Mukherjee, Stephen Gottschalk, Stephen Gottschalk, Stephen Gottschalk, Cliona M. Rooney, Cliona M. Rooney, Cliona M. Rooney, Cliona M. Rooney   +21 more
doaj   +1 more source

Spectral Domain Sampling of Graph Signals

, 2018
Sampling methods for graph signals in the graph spectral domain are presented. Though conventional sampling of graph signals can be regarded as sampling in the graph vertex domain, it does not have the desired characteristics in regard to the graph ...
Tanaka, Yuichi
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

On the origins of scaling corrections in ballistic growth models

, 2014
We study the ballistic deposition and the grain deposition models on two-dimensional substrates. Using the Kardar-Parisi-Zhang (KPZ) ansatz for height fluctuations, we show that the main contribution to the intrinsic width, which causes strong ...
Alves, Sidiney G., Ferreira, Silvio C., Oliveira, Tiago J.   +2 more
core   +2 more sources

Two‐Dimensional Triferroics: From Fundamental Couplings to Multifunctional Applications

Advanced Science, EarlyView.
This graphic summarizes the three main types of currently reported 2D triferroic couplings. From the structural perspective, existing systems can be broadly classified into two categories, which exhibit distinct symmetry features and coupling behaviors. Beyond the lattice difference, a third type involves the interplay among ferroelectricity, magnetism,
Yang Li, Jialin Gong, Zhiqing Li
wiley   +1 more source

Engineering anti‐GD2 monoclonal antibodies for cancer immunotherapy [PDF]

FEBS Letters, 2013
Ganglioside GD2 is highly expressed on neuroectoderm‐derived tumors and sarcomas, including neuroblastoma, retinoblastoma, melanoma, small cell lung cancer, brain tumors, osteosarcoma, rhabdomyosarcoma, Ewing's sarcoma in children and adolescents, as well as liposarcoma, fibrosarcoma, leiomyosarcoma and other soft tissue sarcomas in adults.
Ahmed, Mahiuddin, Cheung, Nai-Kong V.
openaire   +2 more sources