Results 81 to 90 of about 19,474 (223)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

GD2 expression in breast cancer. [PDF]

, 2017
Breast cancer (BC) is a heterogeneous disease, including different subtypes having diverse incidence, drug-sensitivity and survival rates. In particular, claudin-low and basal-like BC have mesenchymal features with a dismal prognosis.
DOMINICI, Massimo, SPANO, Maria Carlotta, Giulia Orsi, ORSI, GIULIA, BARBOLINI, MONICA, Shaniko Kaleci, Enrico Orvieto, Roberto D’Amico, GUARNERI, VALENTINA, PRAPA, MALVINA, PETRACHI, TIZIANA, Spano, Carlotta, CONTE, PIERFRANCO, MANNI, Paola, ORVIETO, ENRICO, Maria Vittoria Dieci, Tiziana Petrachi, Guido Ficarra, Ficarra, G, Conte, P, CASCINU, Stefano, Guarneri, V, TAZZIOLI, Giovanni, PIACENTINI, Federico, Carlotta Spano, Dieci, Mv, D'AMICO, Roberto, Orvieto, E, MASTROLIA, ILENIA, KALECI, SHANIKO, Giovanni Tazzioli, Stefano Cascinu, Valentina Guarneri, Federico Piacentini, Monica Barbolini, Paola Manni, Pierfranco Conte, Massimo Dominici, DIECI, MARIA VITTORIA, Ficarra, Guido, Malvina Prapa, Ilenia Mastrolia   +41 more
core   +1 more source

GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision [PDF]

, 2020
Retinoblastoma (RB) is a pediatric retinal tumor that overexpresses the ganglioside GD2. Although it is treatable in patients with early diagnosis, patients may lose one or two eyes.
Han, Z., Chen, Y., Zheng, M., Landoni, E., Dotti, G., Ahn, S., Wang, K., Savoldo, B.   +7 more
core   +1 more source

Next‐Generation CAR‐T Cell Therapy: From Modular Design to Clinical Expansion

Exploration, EarlyView.
Over the past decades, chimeric antigen receptor (CAR)‐T cell therapy has evolved from a linear engineering concept into a powerful yet constrained immunotherapy, limited by tumour microenvironment barriers, immune evasion, and manufacturing complexity.
Yuesong Bai, Jintao Qin, Zongjun Dai, Ran Yan, Yong Yang, Wenguang Wang   +5 more
wiley   +1 more source

Global Impact of Monoclonal Antibodies (mAbs) in Children: A Focus on Anti-GD2

Cancers, 2023
Simple Summary Despite being in use for almost 50 years, monoclonal antibodies face limitations in their implementation in clinical practice, particularly in pediatrics and pediatric cancer.
C. Larrosa, J. Mora, Nai-Kong V. Cheung
semanticscholar   +1 more source

La gD2 coadministrada con el AFCo1 por vía intranasal induce inmunidad protectora contra virus de herpes simple tipo 2 en ratones

VacciMonitor, 2012
La infección por virus herpes simple tipo 2 (VHS-2) continúa siendo un problema de salud mundial. Esta infección es transmitida sexualmente y es la principal causa de úlceras genitales.
Osmir Cabrera , Maribel Cuello , Karolina Thörn , Josefine Peerson, Madelene Lindqvist, Miriam Lastre, Elizabeth González, Caridad Zayas, Julio Balboa, Belkis Romeo, Ali Sarandi, Oliver Pérez   +11 more
doaj  

Expression of GD2 and GD3 in peripheral neuroblastic tumors

Indian Journal of Pathology and Microbiology
Purpose: The aim of this study was to explore the correlation between the expression of GD2 and GD3 and the histopathological types, risk groups, and chemotherapy in peripheral neuroblastic tumors (pNTs) and provide a theoretical basis for the selection ...
Xia Wei, Shaomei Li, Yizhen Wang
doaj   +1 more source

Virus-free CRISPR knock-in of a chimeric antigen receptor into KLRC1 generates potent GD2-specific natural killer cells.

Molecular Therapy
Natural killer (NK) cells are an appealing off-the-shelf, allogeneic cellular therapy due to their cytotoxic profile. However, their activity against solid tumors remains suboptimal in part due to the upregulation of NK-inhibitory ligands, such as HLA-E,
K. Shankar, Isabelle Zingler-Hoslet, D. Tabima, Seth R T Zima, Lei Shi, Kirstan Gimse, M. Forsberg, Varun Katta, Sage Z. Davis, Daniel Maldonado, Brittany E. Russell, Muhammed Murtaza, Shengdar Q. Tsai, Jose M. Ayuso, C. Capitini, Krishanu Saha   +15 more
semanticscholar   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Invitro photothermal destruction of neuroblastoma cells using carbon nanotubes conjugated with GD2 monoclonal antibody

, 2009
Despite aggressive multimodality therapy, most neuroblastoma-bearing patients relapse and survival rate remains poor. Exploration of alternative therapeutic modalities is needed.
Hsu, Wen Ming, Wang, Chung Hao, Peng, Ching An, Huang, Yao Jhang, Chang, Chia Wei, Ching-An Peng, Wen-Ming Hsu, Yao-Jhang Huang, Chia-Wei Chang, Chung-Hao Wang   +9 more
core   +1 more source