Results 81 to 90 of about 14,298 (222)
Interplay of spin-dependent delocalization and magnetic anisotropy in the ground and excited states of [Gd2@C78]− and [Gd2@C80]− [PDF]
The Journal of Chemical Physics, 2017 The magnetic properties and electronic structure of the ground and excited states of two recently characterized endohedral metallo-fullerenes, [Gd2@C78]− (1) and [Gd2@C80]− (2), have been studied by theoretical methods. The systems can be considered as [Gd2]5+ dimers encapsulated in a fullerene cage with the fifteen unpaired electrons ferromagnetically
Popov, Alexey A. +5 more
openaire +4 more sources
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Identification and Tumour-Binding Properties of a Peptide with High Affinity to the Disialoganglioside GD2. [PDF]
PLoS ONE, 2016 Neuroectodermal tumours are characterized by aberrant processing of disialogangliosides concomitant with high expression of GD2 or GD3 on cell surfaces. Antibodies targeting GD2 are already in clinical use for therapy of neuroblastoma, a solid tumour of ...
Jan Müller +7 more
doaj +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma. Reply
, 2023 To the Editor: Del Bufalo et al. (April 6 issue)(1) describe the treatment of patients with relapsed or refractory pediatric neuroblastoma with chimeric antigen receptor (CAR)-expressing T cells that target the disialoganglioside GD2 and express the ...
Locatelli F.
core +1 more source
Computer Graphics Forum, EarlyView.Abstract Network visualization has traditionally relied on heuristic metrics, such as stress, under the assumption that optimizing them leads to aesthetic and informative layouts. However, no single metric consistently produces the most effective results.
X. Li, P. Zhang, X. Wang, H. Shen, Y. Hu
wiley +1 more source
Targeting disialoganglioside GD2 with chimeric antigen receptor-redirected T cells in lung cancer
, 2022 International audienceBackground We explored whether the disialoganglioside GD2 (GD2) is expressed in small cell lung cancer (SCLC) and non-SCLC (NSCLC) and can be targeted by GD2-specific chimeric antigen receptor (CAR) T cells.
Reppel, Loïc +9 more
core +1 more source
Cladistics, EarlyView.Abstract A long‐standing challenge in phylogenomics has been the resolution of relationships originated from ancient radiations. In these cases, phenomena such as incomplete lineage sorting can increase the support for conflicting resolutions. Most of the diversity in the Class Bivalvia originated during an Ordovician radiation; indeed, several deep ...
Alessandro Formaggioni +7 more
wiley +1 more source
SAP-like cells can be enriched by sorting for GD2.
, 2013 (A) A subset of the low-enrichment NCSC-like population expresses GD2. ESC-derived low-enriched NCSC cultures were sorted into GD2− and GD2+ fractions. Left upper panel shows the isotype control, right upper panel the GD2-stained population and the lower
Joachim Wahl (144304) +6 more
core +1 more source
CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma
Nature CommunicationsNovel chimeric antigen receptor (CAR) T-cell approaches are needed to improve therapeutic efficacy in solid tumors. High-risk neuroblastoma is an aggressive pediatric solid tumor that expresses cell-surface GPC2 and GD2 with a tumor microenvironment ...
Guillem Pascual-Pasto +22 more
doaj +1 more source