Results 41 to 50 of about 13,346 (214)

Expression of ganglioside GD2 on colorectal adenocarcinoma cells [PDF]

Biomeditsinskaya Khimiya, 2020
Using flow cytometry GD2 ganglioside expression was evaluated both on colorectal adenocarcinoma cell lines and on tumor tissue samples from colorectal cancer patients. The marker was found on EpCAM-positive tumor cells in 6 of 12 patients' samples but not on the HT29 and CaCo-2 cell lines. GD2 expression was not an exceptional feature of cancer stem
A Yu, Lupatov, A M, Gisina, Y S, Kim, S A, Bykasov, N N, Volchenko, D V, Sidorov, K N, Yarygin, R V, Kholodenko   +7 more
openaire   +2 more sources

Naxitamab Activity in Neuroblastoma Cells Is Enhanced by Nanofenretinide and Nanospermidine

Pharmaceutics, 2023
Neuroblastoma cells highly express the disialoganglioside GD2, a tumor-associated carbohydrate antigen, which is also expressed in neurons, skin melanocytes, and peripheral nerve fibers.
Lucrezia Galassi, Martina Rossi, Pietro Lodeserto, Monia Lenzi, Francesca Borsetti, Manuela Voltattorni, Giovanna Farruggia, Paolo Blasi, Isabella Orienti   +8 more
doaj   +1 more source

Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication [PDF]

, 2022
The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children with high-risk neuroblastoma.
Cochran, Jennifer R, Marjon, Kristopher D, Weissman, Irving L., Majeti, Ravindra, Vilches-Moure, Jose G., Weissman, Irving L, Brewer, Rachel E, Radosevich, Molly Thomas, Theruvath, Johanna, Majzner, Robbie G., Linde, Miles H, Marshall, Payton L, Vilches-Moure, Jose G, Sage, Julien, Smith, Benjamin A. H., Geraghty, Anna C., Lattin, John, Bertozzi, Carolyn R, Marshall, Payton L., Cochran, Jennifer R., Coles, Garry L., Tousley, Aidan, Sotillo, Elena, Pons, Jaume, Monje, Michelle, Geraghty, Anna C, Huang, Jing, Barkal, Amira, Brewer, Rachel E., Marjon, Kristopher D., Mackall, Crystal L, Xu, Peng, Nasholm, Nicole, Weiss, William A., Kuo, Tracy C, Sorensen, Poul H, Banuelos, Allison, Sangalang, Emma RB, Sorensen, Poul H., Silberstein, John L, He, Andy, Sangalang, Emma R. B., Heitzeneder, Sabine, Silberstein, John L., Smith, Benjamin AH, Linde, Miles H., Coles, Garry L, Daldrup-Link, Heike E., Dalton, Guillermo Nicolas, Fernandes, Ricardo, Wu, Wei, Delaidelli, Alberto, Weiss, William A, Kiru, Louise, Dhingra, Shaurya, Kuo, Tracy C., Bertozzi, Carolyn R., Mackall, Crystal L., Menard, Marie, Daldrup-Link, Heike E, Majzner, Robbie G   +60 more
core   +1 more source

CAR-T Cell Therapy: A Door Is Open to Find Innumerable Possibilities of Treatments for Cancer Patients

Turkish Journal of Hematology, 2018
Seven years ago a chronic lymphocytic leukemia patient was for the first time successfully treated with chimeric antigen receptor (CAR)-modified T cells (CAR-T cells) to target CD19 overexpression in tumor cells. This was the beginning of the development
Lorena Perez - Amill, Berta Marzal, Alvaro Urbano - Ispizua, Manel Juan, Beatriz Martín - Antonio   +4 more
doaj   +1 more source

Functionalized GD2 Electrochemical Immunosensor to Diagnose Minimum Residual Disease of Bone Marrow in Neuroblastoma Effectively

Biosensors, 2023
Neuroblastoma (NB) is known as the “king of childhood tumors” due to its highly metastatic, recurrence-prone, and difficult-to-treat characteristics.
Chong Chen, Chang Hu, Baixun He, Yongchang Bai, Feng He, Shuang Li, Cherie S. Tan   +6 more
doaj   +1 more source

Does GD2 synthase (GD2S) detect cancer stem cells in blood samples of breast carcinomas? [PDF]

Journal of Applied Biomedicine, 2021
Cancer stem cells (CSCs) are a theorized subset of cells within the tumor that is thought to drive disease recurrence and metastatic spread. The aim of this study is to investigate mRNA and protein levels of ganglioside GD2 synthase (GD2S), in breast cancer (BC) patients.65 PBMCs of preoperative BC patients without chemotherapy were compared to PBMCs ...
Maryam, Mansoori, Isa, Abdi Rad, Alireza, Mirzaei, Kevin J, Tam, Seyed, Mohsen Hosseini, Rahim, Mahmodlu, Fatemeh, Mansouri, Leili, Saeednejad Zanjani, Zahra, Madjd   +8 more
openaire   +2 more sources

Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients

Journal of Hematology & Oncology, 2018
Background Chimeric antigen receptor (CAR)-engineered T cells have demonstrated promising clinical efficacy in patients with B cell lymphoma. However, the application of CAR-T cell therapy in the treatment of other solid tumors has been limited.
Jiayi Yu, Xiaowen Wu, Junya Yan, Huan Yu, Longwen Xu, Zhihong Chi, Xinan Sheng, Lu Si, Chuanliang Cui, Jie Dai, Meng Ma, Tianxiao Xu, Yan Kong, Jun Guo   +13 more
doaj   +1 more source

Neuromuscular synaptic transmission in aged ganglioside-deficient mice [PDF]

, 2011
Gangliosides are sialylated glycosphingolipids that are present in high density on neuronal membranes, especially at synapses, where they are assumed to play functional or modulating roles.
Todorov, Boyan, Furukawa, Keiko, Furukawa, K., Plomp, J.J., Verschuuren, Jan J., Willison, H.J., Furukawa, Koichi, Plomp, Jaap J., Jacobs, B.C., Todorov, B., Willison, Hugh J., Jacobs, Bart C., Zitman, F.M.P., Verschuuren, J.J., Zitman, Femke M.P.   +14 more
core   +1 more source

Differential roles of gangliosides in malignant properties of melanomas. [PDF]

PLoS ONE, 2018
Ganglioside GD3 is widely expressed in human malignant melanomas, and has been reported to be involved in the increased cell proliferation and invasion.
Yuhsuke Ohmi, Mariko Kambe, Yuki Ohkawa, Kazunori Hamamura, Orie Tajima, Rika Takeuchi, Koichi Furukawa, Keiko Furukawa   +7 more
doaj   +1 more source

Anti-GD2 IgA kills tumors by neutrophils without antibody-associated pain in the preclinical treatment of high-risk neuroblastoma

Journal for ImmunoTherapy of Cancer, 2021
Background The addition of monoclonal antibody therapy against GD2 to the treatment of high-risk neuroblastoma led to improved responses in patients. Nevertheless, administration of GD2 antibodies against neuroblastoma is associated with therapy-limiting
Stefan Nierkens, Niels Eijkelkamp, Maaike Nederend, Jeanette Leusen, Mitchell Evers, Marjolein Stip, Kaylee Keller, Hanneke Willemen, Marco Jansen, Chilam Chan, Kevin Budding, Thomas Valerius, Friederike Meyer-Wentrup   +12 more
doaj   +1 more source