Results 41 to 50 of about 25,935 (265)

Chimeric antibody c.8B6 to O-acetyl-GD2 mediates the same efficient anti-neuroblastoma effects as therapeutic ch14.18 antibody to GD2 without antibody induced allodynia. [PDF]

PLoS ONE, 2014
Anti-GD2 antibody is a proven therapy for GD2-positive neuroblastoma. Monoclonal antibodies against GD2, such as chimeric mAb ch14.18, have become benchmarks for neuroblastoma therapies.
Mickaël Terme, Mylène Dorvillius, Denis Cochonneau, Tanguy Chaumette, Wenhua Xiao, Mitchell B Diccianni, Jacques Barbet, Alice L Yu, François Paris, Linda S Sorkin, Stéphane Birklé   +10 more
doaj   +1 more source

Expression of ganglioside GD2 on colorectal adenocarcinoma cells [PDF]

Biomeditsinskaya Khimiya, 2020
Using flow cytometry GD2 ganglioside expression was evaluated both on colorectal adenocarcinoma cell lines and on tumor tissue samples from colorectal cancer patients. The marker was found on EpCAM-positive tumor cells in 6 of 12 patients' samples but not on the HT29 and CaCo-2 cell lines. GD2 expression was not an exceptional feature of cancer stem
A Yu, Lupatov, A M, Gisina, Y S, Kim, S A, Bykasov, N N, Volchenko, D V, Sidorov, K N, Yarygin, R V, Kholodenko   +7 more
openaire   +2 more sources

RNA Sequencing-Based Identification of Ganglioside GD2-Positive Cancer Phenotype

Biomedicines, 2020
The tumor-associated ganglioside GD2 represents an attractive target for cancer immunotherapy. GD2-positive tumors are more responsive to such targeted therapy, and new methods are needed for the screening of GD2 molecular tumor phenotypes. In this work,
Maxim Sorokin, Irina Kholodenko, Daniel Kalinovsky, Tatyana Shamanskaya, Igor Doronin, Dmitry Konovalov, Aleksei Mironov, Denis Kuzmin, Daniil Nikitin, Sergey Deyev, Anton Buzdin, Roman Kholodenko   +11 more
doaj   +1 more source

GD2-specific chimeric antigen receptor-modified T cells targeting retinoblastoma – assessing tumor and T cell interaction

Translational Oncology, 2021
A novel disialoganglioside 2 (GD2)-specific chimeric antigen receptor (CAR)-modified T cell therapy against retinoblastoma (RB) were generated. GD2-CAR consists of a single-chain variable fragment (scFv) derived from a monoclonal antibody, hu3F8, that is
Jatuporn Sujjitjoon, Elias Sayour, Shih-Ting Tsao, Mongkol Uiprasertkul, Kleebsabai Sanpakit, Jassada Buaboonnam, Pa-thai Yenchitsomanus, La-ongsri Atchaneeyasakul, Lung-Ji Chang   +8 more
doaj   +1 more source

Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases [PDF]

, 2008
Background: Paraneoplastic neurological syndromes (PNS) are indirect remote effects of cancer on the nervous system, often associated with the presence of specific serum antibodies.
Hoffmann, L. A., Jarius, S., Johannis, W., Koenig, F., Krumbholz, Markus, La Fougere, Christian, Newman, T., Pellkofer, Hannah Luise, Schueller, M., Vincent, A., Voltz, Raymond   +10 more
core   +1 more source

Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology. [PDF]

PLoS ONE, 2015
Ganglioside GD2 is a plasma membrane glycosphinogolipid. In healthy adults it is expressed at low levels, but it is over-expressed in many cancers. For cancer therapy, GD2 is targeted with anti-GD2 monoclonal antibodies (mAbs), and one adverse side ...
Wenyong Tong, Mario Maira, Martin Gagnon, H Uri Saragovi   +3 more
doaj   +1 more source

Long term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy [PDF]

, 2011
Background: The treatment of high-risk neuroblastoma patients consists of multimodal induction therapy to achieve remission followed by consolidation therapy to prevent relapses. However, the type of consolidation therapy is still discussed controversial.
Simon, Thorsten, Hero, Barbara, Faldum, Andreas, Handgretinger, Rupert, Schrappe, Martin, Klingebiel, Thomas, Berthold, Frank   +6 more
core   +1 more source

Neural Ganglioside GD2+ Cells Define a Subpopulation of Mesenchymal Stem Cells in Adult Murine Bone Marrow

Cellular Physiology and Biochemistry, 2013
Background/Aims: Due to the lack of specific markers, the isolation of pure mesenchymal stem cells (MSCs) from murine bone marrow remains an unsolved problem.
Jie Xu, WenJun Fan, Xi Xiang Tu, Teng Zhang, Zhi Jie Hou, Tao Guo, Xin Shu, Xi Luo, Yang Liu, Fei Peng, Chang Wang, LingZhi Xu, Han Zhou, Quentin Liu   +13 more
doaj   +1 more source

Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma

Biomolecules, 2022
Neuroblastoma is one of the few childhood cancers that carries a tumor-specific antigen in the form of a glycolipid antigen known as GD2. It has restricted expression in normal tissue, such as peripheral afferent nerves.
Godfrey Chi-Fung Chan, Carol Matias Chan
doaj   +1 more source

Luminescence tuning of MOFs via ligand to metal and metal to metal energy transfer by co-doping of 2∞[Gd2Cl6(bipy)3]*2bipy with europium and terbium [PDF]

, 2012
The series of anhydrous lanthanide chlorides LnCl3, Ln=Pr–Tb, and 4,4'-bipyridine (bipy) constitute isotypic MOFs of the formula 2∞[Ln2Cl6(bipy)3]*2bipy.
Abrahams, Batista, Bauer, Bayari, Binnemans, Braga, Brito, Bünzli, C. Feldmann, C. J. Höller, Cheetham, Chen, Chen, Chen, Crosby, Crosby, Czakis-Sulikowska, Czakis-Sulikowska, Czakis-Sulikowska, Daiguebonne, de Lill, Ebendorff-Heidepriem, Eddaoudi, Eliseeva, Eremenkoa, Faulkner, Ferey, Ferey, Ferey, Furukawa, Guo, Guo, Gándara, Habib, Hermes, Hoskins, Huang, Höller, Höller, Höller, J. Heck, Janiak, Jiang, K. Müller-Buschbaum, Kaskel, Kerbellec, Kitagawa, Kitagawa, Kuroda, Lan, Le, Liang, Liu, Liu, Liu, Loiseau, Long, M. Mai, Meyer, Müller, Müller-Buschbaum, Müller-Buschbaum, Müller-Buschbaum, Müller-Buschbaum, Müller-Buschbaum, P. R. Matthes, Pan, Ramsahye, Raphael, Ravilious, Rocha, S. J. Sedlmaier, S. Schmiechen, Sabbatini, Serre, Serre, Shannon, Topacli, Voloshin, W. Schnick, Wang, Weissman, Whan, Xiong, Yaghi, Yang, Yang, Zhang, Zhang, Zhang, Zurawski   +90 more
core   +1 more source