Results 21 to 30 of about 14,298 (222)

Surface expression of the immunotherapeutic target GD2 in osteosarcoma depends on cell confluency

Cancer Reports, 2021
Background Chimeric antigen receptor (CAR) T‐cell therapy of pediatric sarcomas is challenged by the paucity of targetable cell surface antigens. A candidate target in osteosarcoma (OS) is the ganglioside GD2, but heterogeneous expression of GD2 limits ...
Malena Wiebel, Sareetha Kailayangiri, Bianca Altvater, Jutta Meltzer, Kay Grobe, Sabine Kupich, Claudia Rossig   +6 more
doaj   +1 more source

GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cells

OncoImmunology, 2020
Expression of the disialoganglioside GD2 has been identified as a marker antigen associated with a breast cancer stem-like cell (BCSC) phenotype. Here, we report on the evaluation of GD2 as a BCSC-specific target antigen for immunotherapy. GD2 expression
Christian M. Seitz, Sarah Schroeder, Philipp Knopf, Ann-Christin Krahl, Jana Hau, Sabine Schleicher, Manuela Martella, Leticia Quintanilla-Martinez, Manfred Kneilling, Bernd Pichler, Peter Lang, Daniel Atar, Karin Schilbach, Rupert Handgretinger, Patrick Schlegel   +14 more
doaj   +1 more source

A herpes simplex virus 2 (HSV-2) glycoprotein D-expressing nonreplicating dominant-negative HSV-2 virus vaccine is superior to a gD2 subunit vaccine against HSV-2 genital infection in guinea pigs. [PDF]

PLoS ONE, 2014
We recently constructed a novel non-replicating dominant-negative HSV-2 recombinant viral vaccine (CJ2-gD2) capable of expressing various HSV-2 antigens that are dominant targets of HSV-2-specific CD8 T-cell response.
Pengwei Zhang, Lining Xie, John W Balliet, Danilo R Casimiro, Feng Yao   +4 more
doaj   +1 more source

Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells.

, 2017
Aromatase is a critical enzyme in the irreversible conversion of androgens to oestrogens, with inhibition used clinically in hormone-dependent malignancies.
Bryan W Day (7953413), Jann N Sarkaria (7953407), Joanne M Ramsey (7953398), Tatjana Heilinger (7953395), Andrew W Boyd (7953416), Amanda Tivnan (163017), Ella L Kim (7953419), Jochen Prehn (7895672), Sally-Ann Cryan (7896101), Gemma O'Connor (7953401), Brett W Stringer (7953410), Jenny L Pokorny (7953404), Holger N Lode (7953422)   +12 more
core   +4 more sources

GD2-Targeted Immunotherapy and Radioimmunotherapy [PDF]

Seminars in Oncology, 2014
Ganglioside GD2 is a tumor-associated surface antigen found in a broad spectrum of human cancers and stem cells. They include pediatric embryonal tumors (neuroblastoma, retinoblastoma, brain tumors, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma), as well as adult cancers (small cell lung cancer, melanoma, soft tissue sarcomas).
Konstantin, Dobrenkov, Nai-Kong V, Cheung   +1 more
openaire   +2 more sources

CAR-T Cell Therapy: A Door Is Open to Find Innumerable Possibilities of Treatments for Cancer Patients

Turkish Journal of Hematology, 2018
Seven years ago a chronic lymphocytic leukemia patient was for the first time successfully treated with chimeric antigen receptor (CAR)-modified T cells (CAR-T cells) to target CD19 overexpression in tumor cells. This was the beginning of the development
Lorena Perez - Amill, Berta Marzal, Alvaro Urbano - Ispizua, Manel Juan, Beatriz Martín - Antonio   +4 more
doaj   +1 more source

Functionalized GD2 Electrochemical Immunosensor to Diagnose Minimum Residual Disease of Bone Marrow in Neuroblastoma Effectively

Biosensors, 2023
Neuroblastoma (NB) is known as the “king of childhood tumors” due to its highly metastatic, recurrence-prone, and difficult-to-treat characteristics.
Chong Chen, Chang Hu, Baixun He, Yongchang Bai, Feng He, Shuang Li, Cherie S. Tan   +6 more
doaj   +1 more source

Long term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy [PDF]

, 2011
Background: The treatment of high-risk neuroblastoma patients consists of multimodal induction therapy to achieve remission followed by consolidation therapy to prevent relapses. However, the type of consolidation therapy is still discussed controversial.
Berthold, Frank, Berthold Frank, Andreas Faldum, Martin Schrappe, Frank Berthold, Handgretinger Rupert, Simon, Thorsten, Barbara Hero, Thomas Klingebiel, Handgretinger, Rupert, Faldum Andreas, Simon Thorsten, Hero, Barbara, Schrappe, Martin, Klingebiel Thomas, Schrappe Martin, Thorsten Simon, Rupert Handgretinger, Hero Barbara, Faldum, Andreas, Klingebiel, Thomas   +20 more
core   +2 more sources

Naxitamab Activity in Neuroblastoma Cells Is Enhanced by Nanofenretinide and Nanospermidine

Pharmaceutics, 2023
Neuroblastoma cells highly express the disialoganglioside GD2, a tumor-associated carbohydrate antigen, which is also expressed in neurons, skin melanocytes, and peripheral nerve fibers.
Lucrezia Galassi, Martina Rossi, Pietro Lodeserto, Monia Lenzi, Francesca Borsetti, Manuela Voltattorni, Giovanna Farruggia, Paolo Blasi, Isabella Orienti   +8 more
doaj   +1 more source

Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication [PDF]

, 2022
The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children with high-risk neuroblastoma.
Cochran, Jennifer R, Marjon, Kristopher D, Weissman, Irving L., Majeti, Ravindra, Vilches-Moure, Jose G., Weissman, Irving L, Brewer, Rachel E, Radosevich, Molly Thomas, Theruvath, Johanna, Majzner, Robbie G., Linde, Miles H, Marshall, Payton L, Vilches-Moure, Jose G, Sage, Julien, Smith, Benjamin A. H., Geraghty, Anna C., Lattin, John, Bertozzi, Carolyn R, Marshall, Payton L., Cochran, Jennifer R., Coles, Garry L., Tousley, Aidan, Sotillo, Elena, Pons, Jaume, Monje, Michelle, Geraghty, Anna C, Huang, Jing, Barkal, Amira, Brewer, Rachel E., Marjon, Kristopher D., Mackall, Crystal L, Xu, Peng, Nasholm, Nicole, Weiss, William A., Kuo, Tracy C, Sorensen, Poul H, Banuelos, Allison, Sangalang, Emma RB, Sorensen, Poul H., Silberstein, John L, He, Andy, Sangalang, Emma R. B., Heitzeneder, Sabine, Silberstein, John L., Smith, Benjamin AH, Linde, Miles H., Coles, Garry L, Daldrup-Link, Heike E., Dalton, Guillermo Nicolas, Fernandes, Ricardo, Wu, Wei, Delaidelli, Alberto, Weiss, William A, Kiru, Louise, Dhingra, Shaurya, Kuo, Tracy C., Bertozzi, Carolyn R., Mackall, Crystal L., Menard, Marie, Daldrup-Link, Heike E, Majzner, Robbie G   +60 more
core   +1 more source