Results 21 to 30 of about 19,474 (223)
Targeting disialoganglioside GD2 with chimeric antigen receptor-redirected T cells in lung cancer [PDF]
, 2022 International audienceBackground We explored whether the disialoganglioside GD2 (GD2) is expressed in small cell lung cancer (SCLC) and non-SCLC (NSCLC) and can be targeted by GD2-specific chimeric antigen receptor (CAR) T cells.
Reppel, Loïc +9 more
core +2 more sources
Molecular Therapy: Nucleic Acids, 2021 Because current mainstream anti-glycolipid GD2 therapeutics for neuroblastoma (NB) have limitations, such as severe adverse effects, improved therapeutics are needed. In this study, we developed a GD2 aptamer (DB99) and constructed a GD2-aptamer-mediated
Liyu Zhang +8 more
doaj +1 more source
Surface expression of the immunotherapeutic target GD2 in osteosarcoma depends on cell confluency
Cancer Reports, 2021 Background Chimeric antigen receptor (CAR) T‐cell therapy of pediatric sarcomas is challenged by the paucity of targetable cell surface antigens. A candidate target in osteosarcoma (OS) is the ganglioside GD2, but heterogeneous expression of GD2 limits ...
Malena Wiebel +6 more
doaj +1 more source
A herpes simplex virus 2 (HSV-2) glycoprotein D-expressing nonreplicating dominant-negative HSV-2 virus vaccine is superior to a gD2 subunit vaccine against HSV-2 genital infection in guinea pigs. [PDF]
PLoS ONE, 2014 We recently constructed a novel non-replicating dominant-negative HSV-2 recombinant viral vaccine (CJ2-gD2) capable of expressing various HSV-2 antigens that are dominant targets of HSV-2-specific CD8 T-cell response.
Pengwei Zhang +4 more
doaj +1 more source
Turkish Journal of Hematology, 2018 Seven years ago a chronic lymphocytic leukemia patient was for the first time successfully treated with chimeric antigen receptor (CAR)-modified T cells (CAR-T cells) to target CD19 overexpression in tumor cells. This was the beginning of the development
Lorena Perez - Amill +4 more
doaj +1 more source
Biosensors, 2023 Neuroblastoma (NB) is known as the “king of childhood tumors” due to its highly metastatic, recurrence-prone, and difficult-to-treat characteristics.
Chong Chen +6 more
doaj +1 more source
, 2017 Aromatase is a critical enzyme in the irreversible conversion of androgens to oestrogens, with inhibition used clinically in hormone-dependent malignancies.
Bryan W Day (7953413) +12 more
core +3 more sources
Naxitamab Activity in Neuroblastoma Cells Is Enhanced by Nanofenretinide and Nanospermidine
Pharmaceutics, 2023 Neuroblastoma cells highly express the disialoganglioside GD2, a tumor-associated carbohydrate antigen, which is also expressed in neurons, skin melanocytes, and peripheral nerve fibers.
Lucrezia Galassi +8 more
doaj +1 more source
Journal of Hematology & Oncology, 2018 Background Chimeric antigen receptor (CAR)-engineered T cells have demonstrated promising clinical efficacy in patients with B cell lymphoma. However, the application of CAR-T cell therapy in the treatment of other solid tumors has been limited.
Jiayi Yu +13 more
doaj +1 more source
Safety and antitumor activity of GD2-Specific 4SCAR-T cells in patients with glioblastoma
Molecular Cancer, 2023 Background This study aimed to validate whether infusion of GD2-specific fourth-generation safety-designed chimeric antigen receptor (4SCAR)-T cells is safe and whether CAR-T cells exert anti-glioblastoma (GBM) activity. Methods A total of eight patients
Zhuo-Hao Liu +11 more
semanticscholar +1 more source