Results 111 to 120 of about 13,346 (214)

Novel anti-GD2 CAR-T cells exhibit superior cytotoxicity against neuroblastoma

European Journal of Inflammation, 2020
Treatment of high-risk paediatric neuroblastoma represents an unmet clinical need. Chimeric antigen receptor-modified T cell (CAR-T) therapy is a promising treatment option, but there exist some challenges regarding specificity and potency.
Cheng ji, Fengtao You, Tingting Zhang, Shuangshuang Fan, Zhichao Han, Shufen Xiang, Yinyan Wang, Binjie Sheng, Tian Wang, Gangli An, Huimin Meng, Lin Yang   +11 more
doaj   +1 more source

Extracellular Vesicles in the Biology and Liquid Biopsy Diagnostics of Pediatric High‐Grade Glioma – Emerging Findings and Opportunities

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Liquid biopsy has emerged as an important diagnostic paradigm impacting care across multiple cancer indications. This is also an area of great interest in pediatric solid tumours, including those affecting the central nervous system (CNS). Of special concern are pediatric high‐grade gliomas (pHGGs) due to the associated diagnostic complexities,
Samia Jahouri, Laura Montermini, Nadim Tawil, Mahsa Jalali, Livia Garzia, Nada Jabado, Janusz Rak   +6 more
wiley   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

In vivo testing of GD2 CAR.

, 2016
Balb-C mice were innocultaed with 1x106 CT26 or CT26-GD2 cell mixed in matrigel. 10 days post tumour inoculation, mice were sub-lethally irradiated (200 rads) and two weeks post tumour injection, mice were intravenously transplanted with a total of 1 ...
Martin Pule (821995), John Anderson (11218), Nourredine Himoudi (2586649), Karin Straathof (2586646), Simon Thomas (236753)   +4 more
core   +1 more source

An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs.

PLoS Pathogens, 2017
A genital herpes vaccine is urgently needed to prevent pain and suffering, reduce the incidence of neonatal herpes, and decrease the risk of HIV acquisition and transmission that accompanies genital infection.
Sita Awasthi, Lauren M Hook, Carolyn E Shaw, Bapi Pahar, Jacob A Stagray, David Liu, Ronald S Veazey, Harvey M Friedman   +7 more
doaj   +1 more source

Effect of GD2 on platelet death.

, 2014
(A) Cell death induced by GD2 stimulation. Platelets untreated or pre-treated with blocking anti-Siglec-7 pAb were incubated with vehicle or GD2. A23187 was used as a positive control for apoptosis.
Hind Hamzeh-Cognasse (78447), Isabelle Anselme-Bertrand (630772), Bruno Pozzetto (449862), Kim Anh Nguyen (416639), Fabrice Cognasse (78451), Olivier Garraud (78450), Patricia Chavarin (78448), Charles-Antoine Arthaud (630773), Sabine Palle (125131)   +8 more
core   +1 more source

Anti-Gd2 Etoposide-Loaded Immunoliposomes For The Treatment of Gd2 Positive Tumors

, 2014
Systemic chemotherapeutics remain the standard of care for most malignancies even though they frequently suffer from narrow therapeutic index, poor serum solubility, and off-target effects.
Brown, Brandon S
core  

Chemistry and biology of tumor-associated ganglioside GD2

, 2012
Effective therapies typically target diseased tissues without significantly affecting healthy tissues. A tumor-related glycosphingolipid (GSL), such as ganglioside GD2, distinguishes neuroectoderm tumors from their healthy counterparts and is a validated
Tong, Wenyong
core  

A Backwards Approach to GD2 Immunofluorescence in Human Neuroblastoma Tissue Samples: From Staining to Slicing

Cells
Background: The disialoganglioside GD2, located at the plasma membrane, is selectively overexpressed in various solid tumors, where it contributes to tumor growth and the development of an aggressive tumor phenotype.
Sara Peggion, Clara Volz, Magdalena Trochimiuk, Isabelle Ariane Bley, Júlia Ramos, Konrad Reinshagen, Laia Pagerols Raluy   +6 more
doaj   +1 more source

Generation and Characterization of a Human/Mouse Chimeric GD2-Mimicking Anti-Idiotype Antibody Ganglidiximab for Active Immunotherapy against Neuroblastoma.

PLoS ONE, 2016
Vaccination with proteins mimicking GD2 that is highly expressed on neuroblastoma (NB) cells is a promising strategy in treatment of NB, a pediatric malignancy with poor prognosis.
Christin Eger, Nikolai Siebert, Diana Seidel, Maxi Zumpe, Madlen Jüttner, Sven Brandt, Hans-Peter Müller, Holger N Lode   +7 more
doaj   +1 more source