Results 111 to 120 of about 19,474 (223)

Supplementary Figure 1 from Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer

Supplementary Figure S1 illustrates the cytotoxic effects of GD2-CARTs (GD2-2840z-CARTs, GD2-28z-CARTs, and GD2-BBz-CARTs) and control T cells on GD2+ tumor cells through in vitro 51Cr release assays.
Takaharu Kimura (18136118), Hiromitsu Nakauchi (18136139), Fumiyuki Takahashi (18136127), Kazutaka Nakashima (16698396), Tomoyuki Yamaguchi (18136121), Shintaro Kinoshita (18136109), Satoshi Yamazaki (18136133), Sakiko Harada (18136124), Koichi Ohshima (16698402), Midori Ishii (18136112), Jun Ando (18136115), Kazuhisa Takahashi (18136136), Miki Ando (18136142), Yozo Nakazawa (18136130)   +13 more
core   +1 more source

Novel anti-GD2 CAR-T cells exhibit superior cytotoxicity against neuroblastoma

European Journal of Inflammation, 2020
Treatment of high-risk paediatric neuroblastoma represents an unmet clinical need. Chimeric antigen receptor-modified T cell (CAR-T) therapy is a promising treatment option, but there exist some challenges regarding specificity and potency.
Cheng ji, Fengtao You, Tingting Zhang, Shuangshuang Fan, Zhichao Han, Shufen Xiang, Yinyan Wang, Binjie Sheng, Tian Wang, Gangli An, Huimin Meng, Lin Yang   +11 more
doaj   +1 more source

Tumor-derived G-CSF induces an immunosuppressive microenvironment in an osteosarcoma model, reducing response to CAR.GD2 T-cells

Journal of Hematology & Oncology
Sarcomas are rare, mesenchymal tumors, representing about 10–15% of all childhood cancers. GD2 is a suitable target for chimeric antigen receptor (CAR) T-cell therapy due to its overexpression in several solid tumors.
Michele Pezzella, C. Quintarelli, M. C. Quadraccia, Andrea Sarcinelli, S. Manni, L. Iaffaldano, Alessio Ottaviani, Roselia Ciccone, A. Camera, M. L. D'Amore, S. Di Cecca, M. Sinibaldi, M. Guercio, Mariasole Aurigemma, Pamela De Falco, Valentina Fustaino, R. Rota, S. Pomella, M. Cassandri, A. Di Giannatale, C. Agrati, V. Bordoni, Federica Guarracino, Michele Massa, G. Del Baldo, M. Becilli, G. M. Milano, F. del Bufalo, F. Locatelli, B. De Angelis   +29 more
semanticscholar   +1 more source

Staff Confidence and Barriers to Complex Clinical Communication in Nursing Homes: A Convergent Mixed‐Methods Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To describe all nursing home staff members' confidence in engaging in complex clinical communication with residents and family carers, and to explore factors affecting their attitudes. Methods A convergent mixed‐methods study used questionnaires (n = 288) and 15 group‐based discussions involving 278 professionals across nine nursing homes ...
Silvia Gonella, Eugenia Malinverni, Luciano Orsi, Filippo Laurenti, Stefania Chiodino, Monica Seminara, Simona Operto, Dario Cencio, Marina Sozzi, Giovanna Marsico, Francesca Paruzzo, Mariagrazia Imperato, Jacopo Olagnero, Maria Rivolta, Ilaria Lovetro, Luigi Stella, Valerio Dimonte, Sara Campagna   +17 more
wiley   +1 more source

FIGURE 1 from Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer

Generation of GD2-CARTs. A, GD2 expression by NSCLC cell line (negative control) and by four SCLC cell lines (red), with isotype control (blue). The plots represent three independent experiments.
Takaharu Kimura (18136118), Hiromitsu Nakauchi (18136139), Fumiyuki Takahashi (18136127), Kazutaka Nakashima (16698396), Tomoyuki Yamaguchi (18136121), Shintaro Kinoshita (18136109), Satoshi Yamazaki (18136133), Sakiko Harada (18136124), Koichi Ohshima (16698402), Midori Ishii (18136112), Jun Ando (18136115), Kazuhisa Takahashi (18136136), Miki Ando (18136142), Yozo Nakazawa (18136130)   +13 more
core   +1 more source

Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells [PDF]

Neuroectoderm-derived tumors characteristically express gangliosides such as GD3 and GD2. Many studies have reported that gangliosides GD3/GD2 enhance malignant phenotypes of cancers.
Kambe, Mariko, Ohkawa, Yuki, Furukawa, Keiko, Mizutani, Momoka, Furukawa, Koichi, Hashimoto, Noboru, Kawamoto, Yoshiyuki, Tajima, Orie, Hasnat, Mohammad Abul, Bhuiyan, Robiul H., Yesmin, Farhana, Kaneko, Kei, Tsuchida, Akiko, Ohmi, Yuhsuke   +13 more
core   +1 more source

Tuning Coordination Chemistry and Composition of Metal–Organic Frameworks for Efficient Hydrogen Production

Carbon Neutralization, Volume 5, Issue 6, November 2026.
The graphical abstract indicates various photo‐ and photoelectrochemical green methods to produce hydrogen energy using MOF‐based assemblies. Different aspects of MOFs, including organic linkers, metal nodes and their advantage as guest support, are explored thoroughly.
Muhammad Ashraf, Nafeesa Sarfraz, Syed Shaheen Shah, Muhammad Ayaz, Khalifa Musa Muhammad, Mujeeb Khan, Sikandar Khan, Nisar Ullah, Ahmed Abdi Hassan, Fazal Raziq, Sharafat Ali, Iftikhar Hussain, Asif A. Tahir, Khalid R. Alhooshani, James H. Rice, Muhammad Nawaz Tahir, Ibrahim Khan   +16 more
wiley   +1 more source

CD24 Positive Nucleus Pulposus Cells in Adult Human Intervertebral Discs Maintain a More Notochordal Phenotype Than GD2 Positive Cells

JOR Spine
Background Notochordal cells (NCs) present in the nucleus pulposus (NP) of the developing human intervertebral disc (IVD) disappear during the first decade of life.
Andra‐Maria Ionescu, Pauline Baird, Sonal Patel, Gareth Howell, Judith A. Hoyland, Stephen M. Richardson   +5 more
doaj   +1 more source

An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs.

PLoS Pathogens, 2017
A genital herpes vaccine is urgently needed to prevent pain and suffering, reduce the incidence of neonatal herpes, and decrease the risk of HIV acquisition and transmission that accompanies genital infection.
Sita Awasthi, Lauren M Hook, Carolyn E Shaw, Bapi Pahar, Jacob A Stagray, David Liu, Ronald S Veazey, Harvey M Friedman   +7 more
doaj   +1 more source

An Orthotopic Xenograft Model for Preclinical Evaluation of CAR T Cell Therapy in Glioblastoma

Current Protocols, Volume 6, Issue 11, November 2026.
Abstract Glioblastoma (GBM) is the most lethal primary brain tumor in adults, and despite intensive research efforts, effective therapeutic breakthroughs remain elusive. Consequently, the standard of care has remained largely unchanged for nearly 30 years, underscoring the need for robust preclinical models to evaluate experimental therapies.
Julian Hübner, Rhonda McFleder, Chi Wang Ip, Miriam Alb, Hermann Einsele, Michael Hudecek, Thomas Nerreter   +6 more
wiley   +1 more source