Results 131 to 140 of about 19,474 (223)

Harnessing a bispecific αGD2 × αCD3 protein engager to target GD2-overexpressing lung tumors

Scientific Reports
Lung cancer remains one of the most prevalent and lethal malignancies worldwide, with persistently poor 5-year survival rates across all stages. The development of novel therapies is therefore crucial for overcoming treatment resistance, improving ...
Nunghathai Sawasdee, Aussara Panya, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus, Chutamas Thepmalee   +4 more
doaj   +1 more source

Generation and Characterization of a Human/Mouse Chimeric GD2-Mimicking Anti-Idiotype Antibody Ganglidiximab for Active Immunotherapy against Neuroblastoma.

PLoS ONE, 2016
Vaccination with proteins mimicking GD2 that is highly expressed on neuroblastoma (NB) cells is a promising strategy in treatment of NB, a pediatric malignancy with poor prognosis.
Christin Eger, Nikolai Siebert, Diana Seidel, Maxi Zumpe, Madlen Jüttner, Sven Brandt, Hans-Peter Müller, Holger N Lode   +7 more
doaj   +1 more source

GD2 in Breast Cancer: A Potential Biomarker and Therapeutic Target

Cancer Genomics & Proteomics
Expression of disialoganglioside GD2 in normal tissues is primarily limited to the central nervous system, peripheral sensory nerve fibers, dermal melanocytes, lymphocytes, and mesenchymal stem cells. Its widespread overexpression in various cancer types
K. Mokbel
semanticscholar   +1 more source

Endohedral fullerenes as qubits: From synthesis to quantum computing applications

InfoMat, Volume 8, Issue 10, October 2026.
Endohedral fullerenes emerge as promising platforms for qubits and qudits. This review surveys the primary synthesis routes, from arc‐discharge to high‐yield molecular surgery. It then details spin manipulation and readout in key systems, including metal‐based, cluster, and nitrogen‐containing fullerenes.
Jeong‐Seok Nam, Jiye Han, Jin‐Myung Choi, Franklin H. Cho, Daniel K. Park, Seunghee Park, Yoshifumi Hashikawa, Yasujiro Murata, Eunsang Kwon, Dong‐Hwan Kim, Junki Kim, Il Jeon   +11 more
wiley   +1 more source

A Backwards Approach to GD2 Immunofluorescence in Human Neuroblastoma Tissue Samples: From Staining to Slicing

Cells
Background: The disialoganglioside GD2, located at the plasma membrane, is selectively overexpressed in various solid tumors, where it contributes to tumor growth and the development of an aggressive tumor phenotype.
Sara Peggion, Clara Volz, Magdalena Trochimiuk, Isabelle Ariane Bley, Júlia Ramos, Konrad Reinshagen, Laia Pagerols Raluy   +6 more
doaj   +1 more source

Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer

Cancer Research Communications
Small cell lung cancer (SCLC) is exceptionally aggressive, with limited treatment options. Disialoganglioside (GD2) is highly expressed on SCLC and is considered a good target for chimeric antigen receptor (CAR) T cells (CART).
Shintaro Kinoshita, Midori Ishii, Jun Ando, Takaharu Kimura, Tomoyuki Yamaguchi, S. Harada, F. Takahashi, Kazutaka Nakashima, Y. Nakazawa, Satoshi Yamazaki, Koichi Ohshima, Kazuhisa Takahashi, H. Nakauchi, M. Ando   +13 more
semanticscholar   +1 more source

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source

Protocol for assessing GD2 on formalin-fixed paraffin-embedded tissue sections using immunofluorescence staining

STAR Protocols
Summary The detection of disialoganglioside GD2 on tumor biopsies, especially in paraffin-embedded tissues, has been challenging due to the glycolipid structure of GD2 and its membrane anchorage.
S. Kailayangiri, B. Altvater, N. Farwick, J. Meltzer, Wolfgang Hartmann, C. Rossig   +5 more
semanticscholar   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior

Scientific Reports
While better management of loco-regional prostate cancer (PC) has greatly improved survival, advanced PC remains a major cause of cancer deaths. Identification of novel targetable pathways that contribute to tumor progression in PC could open new ...
Aaqib M. Bhat, Bhopal C. Mohapatra, H. Luan, Insha Mushtaq, Sukanya Chakraborty, Siddhartha Kumar, Wang-Bin Wu, Ben Nolan, S. Dutta, Matthew D. Storck, Micah Schott, Jane L. Meza, Subodh M. Lele, M. Lin, Leah M. Cook, Eva Corey, C. Morrissey, Donald W. Coulter, M. J. Rowley, A. Natarajan, K. Datta, V. Band, Hamid Band   +22 more
semanticscholar   +1 more source