Results 141 to 150 of about 19,474 (223)

Advances in γδ T Cells: Cutaneous Biology and Therapeutic Potential for Skin Neoplasms

The Journal of Dermatology, Volume 53, Issue 10, Page 1415-1428, October 2026.
ABSTRACT γδ T cells represent an increasingly important subset of T lymphocytes in the immune response to cancer and as a platform for novel immunotherapies. The aim of this review is to synthesize recent insights into the biology and advances in therapeutic applications of γδ T cells in cutaneous malignancies, especially melanoma, within a framework ...
Simo Du, Anika Jallorina, Toru Yoshino, Lingyu Bao, Han Bao, Victor Chang, Henry K. Wong, Derek V. Chan, Stephen K. Richardson, Mary F. Lee‐Wong   +9 more
wiley   +1 more source

Transition to a mesenchymal state in neuroblastoma may be characterized by a high expression of GD2 and by the acquisition of immune escape from NK cells

Frontiers in Immunology
Background Neuroblastoma (NB) is characterized by both adrenergic (ADRN) and undifferentiated mesenchymal (MES) subsets. The ganglioside sialic acid-containing glycosphingolipid (GD2) is widely overexpressed on tumors of neuroectodermal origin promoting ...
S. Di Matteo, M. Bilotta, A. Pelosi, D. Haas, T. Theinert, Gerrit Weber, Paul-Gerhardt Schlegel, M. Berg, Lorenzo Moretta, Enrico Maggi, B. Azzarone, P. Vacca, Nicola Tumino, I. Caruana   +13 more
semanticscholar   +1 more source

Prolactin receptor signalling contributes to the attenuation of stress‐induced hyperthermia during pregnancy

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract During pregnancy, thermoregulation is tightly controlled to protect the foetus from harmful elevated temperatures. Stress‐induced hyperthermia is a component of the stress response that increases alertness to a perceived threat. Previous literature has shown that like other aspects of the stress response, stress‐induced hyperthermia is ...
Andrew M. Stewart, David R. Grattan, Teodora R. Georgescu   +2 more
wiley   +1 more source

Chemistry and biology of tumor-associated ganglioside GD2

, 2012
Effective therapies typically target diseased tissues without significantly affecting healthy tissues. A tumor-related glycosphingolipid (GSL), such as ganglioside GD2, distinguishes neuroectoderm tumors from their healthy counterparts and is a validated
Tong, Wenyong
core  

Latin American Consensus on the Use of Anti-GD2 Monoclonal Antibody Therapy in Patients With High-Risk Neuroblastoma

JCO Global Oncology
PURPOSETo develop a Latin American expert consensus to support, guide, and accelerate the approval and equitable access to anti-GD2 immunotherapy for patients with high-risk neuroblastoma (HR-NB) in the region. Survival rates for HR-NB have improved with
Gabriela I. Villanueva, Sandra Alarcón, Diana Bonilla, Alejandra Casanovas, Mauricio Chaparro, Marcelo D. Coirini, Guido Felizzia, Diego Figueredo, Soad Fuentes-Alabi, Sima Ferman, Simone Franco, Mercedes Garcia Lombardi, Félix Gaytan Morales, Lauro J. Gregianin, Óscar González Ramella, Nathalia Halley, Camila Hashimoto, Arissa Ikeda, Scott Howard, Luis E. Juárez Villegas, Fabiana Morosini, Alberto Olaya Vargas, Vicente Odone-Filho, Nevicolino Pereira de Carvalho Filho, Catalina Peters, Veronica Pérez, Martín Pérez García, Agustina Pollono, Roy Rosado, Lourdes Romero, Haydeé del Pilar Salazar Rosales, Beatriz Silva, Victoria Sobrero, Delia P. Streitenberger, Diana Valencia, Mariana Varela, Milena Villarroel   +36 more
doaj   +1 more source

Concurrent Treatment With Lorlatinib and Dinutuximab Beta Induced Acute Gastric Dilation in a Pediatric Patient With Neuroblastoma

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
Suna Lin, Linjie Li, JiJun Chen, Zhaokun Tao, Lifeng Zhang, Junqing Mao, Jinhu Wang   +6 more
wiley   +1 more source

Early‐Phase Research in Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
Jonathan Cunningham
wiley   +1 more source

FIGURE 2 from Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer

Generation of GD2-CARrejTs. A, Schema, generation of GD2-CARrejTs. T-iPSCs established from LMP2-specific CTL clones were transduced with lentiviral GD2-CAR and GD2-CAR-iPSCs were differentiated into GD2-CARrejTs. B, Flow cytometric analysis of GD2-2840z-
Takaharu Kimura (18136118), Hiromitsu Nakauchi (18136139), Fumiyuki Takahashi (18136127), Kazutaka Nakashima (16698396), Tomoyuki Yamaguchi (18136121), Shintaro Kinoshita (18136109), Satoshi Yamazaki (18136133), Sakiko Harada (18136124), Koichi Ohshima (16698402), Midori Ishii (18136112), Jun Ando (18136115), Kazuhisa Takahashi (18136136), Miki Ando (18136142), Yozo Nakazawa (18136130)   +13 more
core   +1 more source

Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity

, 2010
Ganglioside GD2 is a cell surface glycosphingolipid. Targeting of GD2, i.e., by anti-GD2 mAb 3F8, is used clinically for cancer diagnosis, prognosis, and therapy.
Saragovi, H. Uri, Cheung, Nai-Kong V., Hansford, Karl, Blankenship, John W., Gilbert, Michel, Lubell, William D., Gehring, Kalle, Chowdhury, Shafinaz, Sprules, Tara, Purisima, Enrico O., Meerovitch, Karen, Tong, Wenyong, Gagnon, Martin, Gilbert, Michael   +13 more
core   +1 more source

Combined use of niraparib enhanced the inhibitory effect of Anti-GD2 antibody on osteosarcoma cells

Discover Oncology
Purpose This study aims to investigate the effect of Niraparib in combination with an Anti-GD2 Antibody on osteosarcoma cells. Methods Scratch test was utilized to assess cell migration capacity, while the Transwell experiment was utilized to evaluate ...
Chen Wenyao, Ma Shuai, Fan Yifeng, Li Xinzhi, Que Xiangyong   +4 more
doaj   +1 more source