Results 151 to 160 of about 19,474 (223)

High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model

, 2018
The GD2 ganglioside, which is abundant on the surface of neuroblastoma cells, is targeted by an FDA-approved therapeutic monoclonal antibody and is an attractive tumor-associated antigen for cellular immunotherapy.
Sarah A. Richman, Stephan A. Grupp, Selene Nunez-Cruz, Babak Moghimi, Lucy Z. Li, Zissimos Mourelatos, David M. Barrett, Michael C. Milone, Zachary T. Gershenson   +8 more
core   +1 more source

Combining CD3/GD2 bispecific T cell engager with human Vγ9Vδ2 T cells facilitates neuroblastoma cell targeting and killing in vitro.

PLoS ONE
Cancer immunotherapy, particularly T cell-based therapies, is considered to have strong potential for treating various types of cancer. A promising approach that has emerged is the use of γδ T cell-based strategies for cancer treatment. Neuroblastoma (NB)
Kuntida Kitidee, Sumet Amonyingcharoen, Sarinthip Preedagasamzin, Korakot Atjanasuppat, Piamsiri Sawaisorn, Pornprapa Srimorkun, Sawang Petvises, Wanpen Chaicumpa, Suparerk Borwornpinyo, Usanarat Anurathapan, Suradej Hongeng   +10 more
doaj   +1 more source

In Vitro Photothermal Destruction of Neuroblastoma Cells Using Carbon Nanotubes Conjugated with Gd2 Monoclonal Antibody

, 2011
Despite aggressive multimodality therapy, most neuroblastoma -bearing patients relapse and survival rate remains poor. Exploration of alternative therapeutic modalities is needed. Carbon nanotubes (CNTs), revealing optical absorbance in the near-infrared
黃堯章;張家瑋;許文明;彭慶安, HUANG, YAO-JHANG;CHANG, CHIA-WEI;HSU, WEN-MING;PENG, CHING-AN   +1 more
core  

Aktive Immunisierung mit GD2-Peptidmimotopen und anti-Idiotypen zur Immuntherapie beim Neuroblastom [PDF]

, 2013
Das Neuroblastom ist der häufigste solide, extrakranielle Tumor des Kindesalters. Die schlechte Prognose von Patienten mit fortgeschrittener Erkrankung macht die Entwicklung neuer Therapiemodalitäten zu einem der wichtigsten Forschungsziele auf dem ...
Bleeke, Matthias
core  

CD47 blockade augments anti-GD2 driven phagocytosis in vitro but fails to improve in vivo efficacy in immunocompetent, chemoresistant neuroblastoma preclinical models. [PDF]

PLoS One
Himsworth C, Jackson T, Bowers C, Munnings-Tomes S, Nair G, Muller H, Tucker E, Erbe-Gurel AK, Sondel PM, Chesler L, Mazjner R, Anderson J.   +11 more
europepmc   +1 more source

Engineering a GO-Gd₂TiO₅/g-C₃N₄ ternary nanocomposite for enhanced electrochemical performance and biodiesel catalysis. [PDF]

RSC Adv
Shah RU, Tahir K, Khan IA, Khan IA, Abualsunun WA, Rizk MA.   +5 more
europepmc   +1 more source

FIGURE 3 from Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer

Robust tumor suppressive effect of GD2-CARrejTs in vivo.A, Graphical abstract of in vivo experiment. H446 cells labeled with FFluc/GFP were intravenously injected into NOG mice (1 × 106 cells/mouse) 4 days before treatment.
Takaharu Kimura (18136118), Hiromitsu Nakauchi (18136139), Fumiyuki Takahashi (18136127), Kazutaka Nakashima (16698396), Tomoyuki Yamaguchi (18136121), Shintaro Kinoshita (18136109), Satoshi Yamazaki (18136133), Sakiko Harada (18136124), Koichi Ohshima (16698402), Midori Ishii (18136112), Jun Ando (18136115), Kazuhisa Takahashi (18136136), Miki Ando (18136142), Yozo Nakazawa (18136130)   +13 more
core   +1 more source

Insights into morbidity and mortality in Gaucher disease: a cohort study. [PDF]

Mol Genet Metab Rep
Teixeira LF, Poswar F, Randon DN, Pasqualotto A, Schwartz IVD.   +4 more
europepmc   +1 more source

Developmental Sialylation in Neuroblastoma and Neural-Crest-Derived Tumors. [PDF]

Cancers (Basel)
Swami L, Sharma M, Janmeda P, Mandadapu P, Jamal F, Kumar P, Hardiman KM, Stafman LL.   +7 more
europepmc   +1 more source

Gangliosides in Cutaneous Melanoma: Molecular Mechanisms, Translational Evidence Gaps, and Preclinical Natural-Compound Leads. [PDF]

Int J Mol Sci
Koo DB, Kim K, Kim J, Yun HG, Song EB, Kim MY, Ryu JS, Kim JS, Kim S, Lee HA, Choo YK.   +10 more
europepmc   +1 more source