Results 121 to 130 of about 13,346 (214)

Therapeutic Induction of Tumor Antigen GD2 in Osteosarcoma

Osteosarcoma is the most common primary bone malignancy in children and represents a major challenge in pediatric oncology given its highly aggressive nature. Current therapy consists of a combination of chemotherapy, surgery, and radiation, yet survival
Herman, Samantha
core   +1 more source

Latin American Consensus on the Use of Anti-GD2 Monoclonal Antibody Therapy in Patients With High-Risk Neuroblastoma

JCO Global Oncology
PURPOSETo develop a Latin American expert consensus to support, guide, and accelerate the approval and equitable access to anti-GD2 immunotherapy for patients with high-risk neuroblastoma (HR-NB) in the region. Survival rates for HR-NB have improved with
Gabriela I. Villanueva, Sandra Alarcón, Diana Bonilla, Alejandra Casanovas, Mauricio Chaparro, Marcelo D. Coirini, Guido Felizzia, Diego Figueredo, Soad Fuentes-Alabi, Sima Ferman, Simone Franco, Mercedes Garcia Lombardi, Félix Gaytan Morales, Lauro J. Gregianin, Óscar González Ramella, Nathalia Halley, Camila Hashimoto, Arissa Ikeda, Scott Howard, Luis E. Juárez Villegas, Fabiana Morosini, Alberto Olaya Vargas, Vicente Odone-Filho, Nevicolino Pereira de Carvalho Filho, Catalina Peters, Veronica Pérez, Martín Pérez García, Agustina Pollono, Roy Rosado, Lourdes Romero, Haydeé del Pilar Salazar Rosales, Beatriz Silva, Victoria Sobrero, Delia P. Streitenberger, Diana Valencia, Mariana Varela, Milena Villarroel   +36 more
doaj   +1 more source

Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells [PDF]

Neuroectoderm-derived tumors characteristically express gangliosides such as GD3 and GD2. Many studies have reported that gangliosides GD3/GD2 enhance malignant phenotypes of cancers.
Kambe, Mariko, Ohkawa, Yuki, Furukawa, Keiko, Mizutani, Momoka, Furukawa, Koichi, Hashimoto, Noboru, Kawamoto, Yoshiyuki, Tajima, Orie, Hasnat, Mohammad Abul, Bhuiyan, Robiul H., Yesmin, Farhana, Kaneko, Kei, Tsuchida, Akiko, Ohmi, Yuhsuke   +13 more
core   +1 more source

Application of Molecular Mimicry to Target GD2 Ganglioside

, 2012
GD2 ganglioside is an important example of tumour-associated carbohydrate antigens. Over expression of the GD2 ganglioside is a hallmark of neuroblastoma, while its expression on normal cells is restricted. The antigen is stably expressed on cells of the tumour, and retained during a therapy of the disease (Kramer et al., 2001).
Horwacik, Irena, Rokita, Hanna
openaire   +3 more sources

Combined use of niraparib enhanced the inhibitory effect of Anti-GD2 antibody on osteosarcoma cells

Discover Oncology
Purpose This study aims to investigate the effect of Niraparib in combination with an Anti-GD2 Antibody on osteosarcoma cells. Methods Scratch test was utilized to assess cell migration capacity, while the Transwell experiment was utilized to evaluate ...
Chen Wenyao, Ma Shuai, Fan Yifeng, Li Xinzhi, Que Xiangyong   +4 more
doaj   +1 more source

Model of signal pathways activated by GD2 ligands.

, 2015
A comparison of signals activated by GD2 ligands 3F8 or SS58, compared versus TrkB ligand BDNF. GD2 (a glycolipid with 5 sugars) and TrkB are not to scale.
Mario Maira (781208), Wenyong Tong (781207), H. Uri Saragovi (53495), Martin Gagnon (781209)   +3 more
core   +1 more source

Effective combination treatment of GD2-expressing neuroblastoma and Ewing's sarcoma using anti-GD2 ch14.18/CHO antibody with Vγ9Vδ2+ γδT cells [PDF]

Gamma delta T lymphocytes (γδT cells) have pleiotropic properties including innate cytotoxicity, which make them attractive effectors for cancer immunotherapy.
Fisher, JPH, Frosch, J, Flutter, BR, Wesemann, F, Rossig, C, Anderson, J, Gustafsson, K   +6 more
core  

Invitro photothermal destruction of neuroblastoma cells using carbon nanotubes conjugated with GD2 monoclonal antibody

, 2009
Despite aggressive multimodality therapy, most neuroblastoma-bearing patients relapse and survival rate remains poor. Exploration of alternative therapeutic modalities is needed.
Hsu, Wen Ming, Wang, Chung Hao, Peng, Ching An, Huang, Yao Jhang, Chang, Chia Wei   +4 more
core   +1 more source

Combining CD3/GD2 bispecific T cell engager with human Vγ9Vδ2 T cells facilitates neuroblastoma cell targeting and killing in vitro.

PLoS ONE
Cancer immunotherapy, particularly T cell-based therapies, is considered to have strong potential for treating various types of cancer. A promising approach that has emerged is the use of γδ T cell-based strategies for cancer treatment. Neuroblastoma (NB)
Kuntida Kitidee, Sumet Amonyingcharoen, Sarinthip Preedagasamzin, Korakot Atjanasuppat, Piamsiri Sawaisorn, Pornprapa Srimorkun, Sawang Petvises, Wanpen Chaicumpa, Suparerk Borwornpinyo, Usanarat Anurathapan, Suradej Hongeng   +10 more
doaj   +1 more source

Anti-Neuroblastoma Activity of Gold Nanorods Bound with GD2 Monoclonal Antibody under Near-Infrared Laser Irradiation

, 2011
High-risk neuroblastoma is one of the most common deaths in pediatric oncology. Current treatment of this disease involves a coordinated sequence of chemotherapy, surgery, and radiation.
Ching-An Peng, Chung-Hao Wang, Peng, Ching-An, Wang, Chung-Hao   +3 more
core   +1 more source