Results 131 to 140 of about 2,223,573 (201)

The inhibitory effect of M2 macrophage-derived exosomes on gefitinib resistant lung adenocarcinoma cells through the MIF/TIMP1/CD74 axis

Scientific Reports
Lung adenocarcinoma (LA) ranks among the most common malignant tumors worldwide. M2 macrophage-derived exosomes have been implicated in regulating LA progression and drug resistance.
Jingcui Peng, Yan Zhang, Bin Li, Xin He, Cuimin Ding, Wenxia Hu   +5 more
doaj   +1 more source

MEF2C promotes gefitinib resistance in hepatic cancer cells through regulating MIG6 transcription

, 2018
Introduction: Mitogen-inducible gene 6 ( MIG6) holds a special position in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance.
Zhi Wang, Lin Meng, Lin Li, Wei Liu, Yunhua Wang, Huawu Yan, Hui Zhang   +6 more
core   +1 more source

The m6 RNA methylation regulator KIAA1429 is associated with autophagy‐mediated drug resistance in lung cancer

FASEB BioAdvances
N6‐methyladenosine (m6A) modification plays a crucial role in cancer progression. However, the role of m6A modification‐mediated autophagy underlying non‐small cell lung cancer (NSCLC) gefitinib resistance remains unknown.
Bo Ma, Lei Xiu, Lili Ding
doaj   +1 more source

Gefitinib frequently induces liver damage in patients with lung adenocarcinoma previously treated by chemotherapy

, 2013
Yasoo Sugiura,1 Etsuo Nemoto,1 Osamu Kawai,2 Yasuyuki Ohkubo,2 Hisae Fusegawa,2 Shizuka Kaseda1 1Department of Pulmonary and Thoracic Surgery, 2Department of Respiratory Medicine, Kanagawa National Hospital, Hadano, Japan Background: Gefitinib is known ...
Ohkubo Y, Fusegawa H, Sugiura Y, Kaseda S, Nemoto E, Kawai O   +5 more
core  

CA916798 predicts poor prognosis and promotes Gefitinib resistance for lung adenocarcinoma. [PDF]

BMC Cancer, 2023
He J, Lan X, Liu X, Deng C, Luo H, Wang Y, Kang P, Sun Z, Zhao L, Zhou X.   +9 more
europepmc   +1 more source

Acquired Gefitinib-Resistant Mutation of EGFR in a Chemonaive Lung Adenocarcinoma Harboring Gefitinib-Sensitive Mutation L858R

PLoS Medicine, 2005
Chien-Hung Gow, Jin-Yuan Shih, Yih-Leong Chang, Chong-Jen Yu   +3 more
openaire   +5 more sources

OSGIN1 is a novel TUBB3 regulator that promotes tumor progression and gefitinib resistance in non-small cell lung cancer. [PDF]

Cell Mol Life Sci, 2023
Xie X, Laster KV, Li J, Nie W, Yi YW, Liu K, Seong YS, Dong Z, Kim DJ.   +8 more
europepmc   +1 more source

Pemetrexed induces ROS generation and cellular senescence by attenuating TS-mediated thymidylate metabolism to reverse gefitinib resistance in NSCLC. [PDF]

J Cell Mol Med, 2023
Chen Y, Zhang C, Jin S, Li J, Dai J, Zhang Z, Guo R.   +6 more
europepmc   +1 more source

Aurora-A promotes gefitinib resistance via a NF-kappa B signaling pathway in p53 knockdown lung cancer cells 

, 2020
[[abstract]]Mutations of the p53 tumor suppressor gene are the most common mutations found in human tumors. There is increasing evidence that suggests that p53 status is a determinant of chemosensitivity of tumor cells.
余長澤, Yu, CTR
core  

RTK-regulated miRNAs Mediate Gefitinib Resistance [PDF]

Cancer Discovery, 2012
openaire   +1 more source